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16 条记录 (耗时 0.014 秒)

    Apolipoprotein biopolymer markers predictive of alzheimers disease
    1.
    发明申请
    Apolipoprotein biopolymer markers predictive of alzheimers disease 审中-公开
    预测阿尔茨海默病的载脂蛋白生物聚合物标记物

    公开(公告)号：US20030113808A1

    公开(公告)日：2003-06-19

    申请号：US10020008

    申请日：2001-12-13

    发明人： George Jackowski ,  John Marshall

    IPC分类号： G01N033/53 ,  G01N033/567 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  C07K007/08 ,  C07K016/20

    CPC分类号： C07K14/775

    摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

    摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

    Conjugation of biomolecules using diels-alder cycloaddition
    2.
    发明申请
    Conjugation of biomolecules using diels-alder cycloaddition 审中-公开
    使用diels-alder环加成的生物分子的缀合

    公开(公告)号：US20020068818A1

    公开(公告)日：2002-06-06

    申请号：US09927044

    申请日：2001-08-09

    发明人： Vince Pozsgay

    IPC分类号： A61K039/40 ,  C07K016/20 ,  C07K014/195 ,  C08B037/00

    CPC分类号： C12N11/10 ,  A61K39/0275 ,  A61K39/0283 ,  A61K39/385 ,  A61K47/61 ,  A61K47/643 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C07K1/1077 ,  C08B37/00 ,  C08B37/0021 ,  Y02A50/476 ,  Y02A50/482 ,  Y02A50/484

    摘要： A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of a carrier protein, and a conjugated diene was attached to a carbohydrate hapten. Spontaneous coupling of the carbohydrate and the protein components under very mild conditions provided glycoconjugates containing up to 37 carbohydrate hapten units per carrier protein molecule. The method is also applicable to the immobilization of biomolecules on gel or solid supports. The conjugated products are useful as immunogens and as analytical and diagnostic reagents.

    摘要翻译： 提供了一种使用Diels-Alder环加成反应在中性条件下共价连接碳水化合物，蛋白质，核酸和其他生物分子的方法。 在一个实例中，活性碳 - 碳双键连接到载体蛋白质的游离氨基位点，并且共轭二烯与碳水化合物半抗原连接。 在非常温和的条件下碳水化合物和蛋白质组分的自发偶联提供了每载体蛋白质分子含有多达37个碳水化合物半抗原单位的糖缀合物。 该方法也适用于在凝胶或固体支持物上固定生物分子。 共轭产物可用作免疫原和分析和诊断试剂。

    Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation
    3.
    发明申请
    Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation 审中-公开
    编码干扰素基因的核苷酸序列，抗原蛋白，以及使用它们处理蛋白质聚集的方法

    公开(公告)号：US20030235823A1

    公开(公告)日：2003-12-25

    申请号：US10177104

    申请日：2002-06-24

    申请人： THE UNIVERSITY OF ALABAMA

    发明人： Guy A. Caldwell ,  Kim A. Caldwell

    IPC分类号： C12Q001/68 ,  G01N033/53 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07K016/20 ,  A61K038/17

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2500/04

    摘要： The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1, and DYT2 genes and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of torsin activity, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which encode polypeptides having varying degrees of TOR-1, TOR2, OOC-5 TOR-A, and TOR-B activity. Further, the invention relates to methods of reducing protein aggregation, methods of treating diseases that are caused by protein aggregation, methods of screening potential protein-aggregation-reducing products, methods of screening potential therapeutics of diseases caused by protein aggregation, and pharmaceuticals, therapeutics, and kits comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1, and DYT2 genes and/or polypeptides having torsin activity.

    摘要翻译： 本发明涉及多核苷酸，其包含对应于tor-1，tor-2，ooc-5，DYT1和DYT2基因的多核苷酸序列及其部分，其编码具有不同程度的躯干活性的多肽序列及其部分，以及筛选和 扩增编码多肽序列的多核苷酸，其编码具有不同程度的TOR-1，TOR2，OOC-5TOR-A和TOR-B活性的多肽。 此外，本发明涉及减少蛋白质聚集的方法，治疗由蛋白质聚集引起的疾病的方法，筛选潜在的蛋白质聚集减少产品的方法，筛选由蛋白质聚集引起的疾病的潜在治疗剂的方法以及药物，治疗剂 ，以及包含对应于具有抗转录活性的tor-1，tor-2，ooc-5，DYT1和DYT2基因和/或多肽的多核苷酸序列的试剂盒。

    Immunological detection of neosporosis using a recombinant antigen
    4.
    发明申请
    Immunological detection of neosporosis using a recombinant antigen 审中-公开
    使用重组抗原免疫检测新孢子虫病

    公开(公告)号：US20020146748A1

    公开(公告)日：2002-10-10

    申请号：US09767037

    申请日：2001-01-22

    发明人： L. David Sibley ,  Daniel K. Howe

    IPC分类号： G01N033/53 ,  G01N033/569 ,  C07H021/04 ,  C12N009/00 ,  C07K016/20

    CPC分类号： G01N33/56905 ,  C07K14/44 ,  C07K16/20 ,  G01N2333/44 ,  G01N2469/20

    摘要： An immunological assay method is disclosed which utilizes recombinant antigen, rNcp29, derived from an immunodominant surface antigen of Neospora caninum tachyzoites. Specifically, an ELISA method is disclosed. The method provides sensitive and specific detection of antibodies in sera of infected animals and does not exhibit cross-reaction with antisera against related parasites such as T. gondii. The ELISA method is used to screen animals for the presence of serum antibodies specific to recombinant Ncp29.

    摘要翻译： 公开了一种免疫学测定方法，其利用来自新孢子虫犬速殖子的免疫显性表面抗原的重组抗原rNcp29。 具体地，公开了ELISA方法。 该方法对感染动物的血清中的抗体进行敏感和特异性检测，并且不显示与抗弓形虫相关寄生虫的抗血清的交叉反应。 ELISA方法用于筛选动物对重组Ncp29特异的血清抗体的存在。

    Antibodies to polysaccharide of C. neoformans
    6.
    发明申请
    Antibodies to polysaccharide of C. neoformans 审中-公开
    新型隐球菌多糖的抗体

    公开(公告)号：US20030103977A1

    公开(公告)日：2003-06-05

    申请号：US10254198

    申请日：2002-09-24

    发明人： Arturo Casadevall ,  Matthew D. Scharff ,  Jean Mukherjee

    IPC分类号： A61K039/395 ,  C12P021/04 ,  C07K016/20

    CPC分类号： C07K16/12 ,  A61K39/00

    摘要： This invention relates to monoclonal antibodies which bind to non-enhancing protective epitopes on serotype A, B, C and D strains of C. neoformans, such protective epitopes containing acetyl groups in the polysaccharide of the epitopes. Other monoclonal antibodies of this invention are serotype specific, and bind to acetyl groups on polysaccharide capsule protective epitopes of serotype D strain C. neoformans only. This invention further relates to methods for producing these monoclonal antibodies. These monoclonal antibodies may be passively administered to treat and prevent cryptococcal infection, such as Cryptococcal meningitis, in immunosuppressed patients. These monoclonal antibodies may also be used for detection of fungal infection, for the development of diagnostic serotyping of clinical isolates, and as therapeutic adjuncts to anti-fungal antibiotic therapy.

    摘要翻译： 本发明涉及结合新生隐球菌新型隐球菌血清型A，B，C和D株的非增强性保护性表位的单克隆抗体，在表位多糖中含有乙酰基的保护性表位。 本发明的其它单克隆抗体是血清型特异性的，并且仅结合血清型D株C.新生隐球菌的多糖胶囊保护性表位上的乙酰基。 本发明还涉及生产这些单克隆抗体的方法。 这些单克隆抗体可被动施用以在免疫抑制患者中治疗和预防隐球菌感染，例如隐球菌性脑膜炎。 这些单克隆抗体也可用于检测真菌感染，用于诊断临床分离株的血清分型，以及作为抗真菌抗生素治疗的治疗辅助物质。

    Monoclonal antibodies to Sarcocystis neurona and uses therefor
    7.
    发明申请
    Monoclonal antibodies to Sarcocystis neurona and uses therefor 失效
    单克隆抗体为Sarcocystis神经元并用于此

    公开(公告)号：US20020187517A1

    公开(公告)日：2002-12-12

    申请号：US10140754

    申请日：2002-05-07

    发明人： Antoinette Marsh

    IPC分类号： G01N033/53 ,  G01N033/569 ,  G01N033/537 ,  G01N033/543 ,  C07K016/20

    CPC分类号： G01N33/56905 ,  C07K16/20 ,  Y10S435/81 ,  Y10S435/975

    摘要： The present invention is directed to particular monoclonal antibodies that find use in the identification and purification of Sarcocystis neurona and related antigens. In particular, these antibodies permit the diagnosis of Sarcocystis related diseases such as equine protozoal myeloencephalitis (EPM).

    摘要翻译： 本发明涉及特定的单克隆抗体，其可用于鉴定和纯化Sarcocystis神经元和相关抗原。 特别地，这些抗体允许诊断类似虫体的相关疾病如马原虫性脊髓炎（EPM）。