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    Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation
    1.
    发明申请
    Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation 审中-公开
    编码干扰素基因的核苷酸序列，抗原蛋白，以及使用它们处理蛋白质聚集的方法

    公开(公告)号：US20030235823A1

    公开(公告)日：2003-12-25

    申请号：US10177104

    申请日：2002-06-24

    申请人： THE UNIVERSITY OF ALABAMA

    发明人： Guy A. Caldwell ,  Kim A. Caldwell

    IPC分类号： C12Q001/68 ,  G01N033/53 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07K016/20 ,  A61K038/17

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2500/04

    摘要： The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1, and DYT2 genes and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of torsin activity, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which encode polypeptides having varying degrees of TOR-1, TOR2, OOC-5 TOR-A, and TOR-B activity. Further, the invention relates to methods of reducing protein aggregation, methods of treating diseases that are caused by protein aggregation, methods of screening potential protein-aggregation-reducing products, methods of screening potential therapeutics of diseases caused by protein aggregation, and pharmaceuticals, therapeutics, and kits comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1, and DYT2 genes and/or polypeptides having torsin activity.

    摘要翻译： 本发明涉及多核苷酸，其包含对应于tor-1，tor-2，ooc-5，DYT1和DYT2基因的多核苷酸序列及其部分，其编码具有不同程度的躯干活性的多肽序列及其部分，以及筛选和 扩增编码多肽序列的多核苷酸，其编码具有不同程度的TOR-1，TOR2，OOC-5TOR-A和TOR-B活性的多肽。 此外，本发明涉及减少蛋白质聚集的方法，治疗由蛋白质聚集引起的疾病的方法，筛选潜在的蛋白质聚集减少产品的方法，筛选由蛋白质聚集引起的疾病的潜在治疗剂的方法以及药物，治疗剂 ，以及包含对应于具有抗转录活性的tor-1，tor-2，ooc-5，DYT1和DYT2基因和/或多肽的多核苷酸序列的试剂盒。