知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.016 seconds)

    Serine protease inhibitors compromising a hydrogen-bond acceptor
    1.
    发明申请
    Serine protease inhibitors compromising a hydrogen-bond acceptor 审中-公开
    丝氨酸蛋白酶抑制剂损害氢键受体

    公开(公告)号：US20040235792A1

    公开(公告)日：2004-11-25

    申请号：US10466736

    申请日：2003-12-18

    Inventor： John J Deadman ,  John Spencer ,  Paulette A Greenidge ,  Christopher A Goodwin ,  Vijay Vir Kakkar ,  Michael F Scully ,  Richard Jones Holland

    IPC: A61K031/69 ,  C07F005/04

    CPC classification number: A61K31/69 ,  A61K31/00 ,  C07C335/32 ,  C07F5/02 ,  C07F5/025 ,  C07F5/04

    Abstract: Compounds, useful as protease inhibitors, of the formula (I): where: Ar is a ring or ring system, for example a benzene ring, and may be substituted by one or more moieties in addition to X and LJ; X is a functional group which is a hydrogen-bond acceptor, e.g. a nitro or boronate group BY1Y2; L is a linker, most preferably (CR5R6)nullSnull; J is a moiety containing a basic nitrogen atom but not containing an amino acid residue, preferably amidino, guanidine, amino carboxamido, hydroxylamino, or imidazolyl, or an N-substituted analogue thereof.

    Abstract translation: 用作蛋白酶抑制剂的式（I）化合物：其中：Ar是环或环系，例如苯环，除X和LJ之外，还可被一个或多个部分取代; X是一个官能团，它是一个氢键受体。 硝基或硼酸酯基团BY 1 Y 2; L是接头，最优选（CR 5 R 6）-S-; J是含有碱性氮原子但不含有氨基酸残基，优选脒基，胍，氨基甲酰氨基，羟氨基或咪唑基或其N-取代的类似物的部分。

    Detection of analytes
    4.
    发明申请
    Detection of analytes 审中-公开
    检测分析物

    公开(公告)号：US20020094586A1

    公开(公告)日：2002-07-18

    申请号：US09754219

    申请日：2001-01-05

    Applicant: Sensors for Medicine and Science, Inc.

    Inventor： George Y. Daniloff ,  Aristotle G. Kalivretenos ,  Alexandre V. Nikolaitchik ,  Edwin F. Ullman

    IPC: C07C069/76 ,  C07F005/04

    CPC classification number: G01N33/66

    Abstract: Disclosed are methods for detecting analytes with indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.

    Abstract translation: 公开了用于用指示剂系统检测分析物的方法，所述指示剂体系在暴露于分析物时可能经历分子结构变化。 配置变化影响与指示剂系统相关的可检测质量，从而允许检测分析物的存在或浓度。

    Boron-containing compound, ion-conductive polymer and polyelectrolyte for electrochemical devices
    6.
    发明申请
    Boron-containing compound, ion-conductive polymer and polyelectrolyte for electrochemical devices 有权
    含硼化合物，离子导电聚合物和用于电化学装置的聚电解质

    公开(公告)号：US20040147697A1

    公开(公告)日：2004-07-29

    申请号：US10717645

    申请日：2003-11-21

    Inventor： Takefumi Okumura ,  Shin Nishimura ,  Norio Iwayasu ,  Shoichi Yokoyama ,  Takeshi Yabe

    IPC: C08F130/06 ,  C07F005/04

    CPC classification number: H01M10/0565 ,  C07F5/04 ,  C08F30/06 ,  C08G65/328 ,  C08G79/08 ,  H01B1/122 ,  H01M6/181 ,  H01M10/0525

    Abstract: An object of the present invention is to provide a boron-containing compound capable of forming an ion-conductive polyelectrolyte having high ion-conductive properties, and a polymer of said compound. According to the present invention, there are provided a polymerizable boron-containing compound of (formula 1), a polymer thereof, a polymer of a compound of (formula 2) and a compound of (formula 3), and a polyelectrolyte for electrochemical device comprising either of these polymers and at least one electrolyte salt: 1

    Abstract translation: 本发明的目的是提供一种能够形成具有高离子传导性的离子传导性聚电解质的含硼化合物和所述化合物的聚合物。 根据本发明，提供了（式1）的聚合性含硼化合物，其聚合物，（式2）化合物和（式3）化合物的聚合物和电化学装置用聚电解质 包括这些聚合物中的任一种和至少一种电解质盐：

    Boron chelate complexes
    7.
    发明申请
    Boron chelate complexes 审中-公开
    硼螯合物

    公开(公告)号：US20040063986A1

    公开(公告)日：2004-04-01

    申请号：US10467220

    申请日：2003-09-23

    Inventor： Ulrich Wietelmann ,  Uwe Lischka ,  Klaus Schade ,  Jan-Christoph Panitz

    IPC: C07F005/04

    CPC classification number: H01M10/0525 ,  C07F5/022 ,  C07F5/04 ,  H01G11/06 ,  H01G11/58 ,  H01M10/0568 ,  Y02E60/13

    Abstract: Boron chelate complexes of the general formula 1 are described, where X is either nullC(R1R2)null or nullC(R1R2)nullC(nullO)null, in which R1, R2 independently of one another denote H, alkyl (with 1 to 5 C atoms), aryl, silyl or a polymer, and one of the alkyl radicals R1 or R2 may be bonded to a further chelatoborate radical, or X denotes 1,2-aryl with up to two substituents S in the positions 3 to 6 2 in which S1, S2 independently of one another denote alkyl (with 1 to 5 C atoms), fluorine or a polymer, as well as Mnull denotes Linull, Nanull, Knull, Rbnull, Csnull or null(R3R4R5R6)Nnullnull or Hnull, where R3, R4, R5, R6 independently of one another denote H or alkyl with preferably 1 to 4 C atoms.

    Abstract translation: 描述了通式的硼螯合物，其中X是-C（R 1 R 2） - 或-C（R 1 R 2）-C（= O） - ，其中 R 1，R 2彼此独立地表示H，烷基（具有1至5个C原子），芳基，甲硅烷基或聚合物，并且烷基R 1或R 2之一可以是 键合到另一个螯合硼酸根基团，或X表示在3至6位上具有至多两个取代基S的1,2-芳基，其中S 1，S 2彼此独立地表示烷基（具有1至5个碳原子 原子），氟或聚合物，以及M +表示Li +，Na +，K +，Rb +，Cs +或[（R 3 R 4） 其中R 3，R 4，R 5，R 6彼此独立地表示H或烷基，其中R 3，R 5，R 5， 优选1至4个C原子。

    Processes for the purification of tocopherol and/or sterol compounds and compositions containing orthoborate ester mixtures
    9.
    发明申请
    Processes for the purification of tocopherol and/or sterol compounds and compositions containing orthoborate ester mixtures 有权
    纯化生育酚和/或固醇化合物和含有原硼酸酯混合物的组合物的方法

    公开(公告)号：US20020072620A1

    公开(公告)日：2002-06-13

    申请号：US09922208

    申请日：2001-08-03

    Inventor： Patrick M. McCurry JR. ,  Stephen W. Turner ,  Carl Pickens ,  Jan R. Varvil

    IPC: C07J009/00 ,  C07D311/76 ,  C07F005/04

    CPC classification number: C07D311/72

    Abstract: Processes for purifying compounds are disclosed which include reacting (i) a mixture of at least one tocopherol compound or sterol compound, and an alcohol having from about 10 to 30 carbons with (ii) one or more boron-containing compounds to form a second mixture of orthoborate esters, wherein the mole ratio of tocopherol, sterol and alcohol to boron is at least about 2.5:1; heating the second mixture to form a residue containing the orthoborate esters; contacting the residue with a compound capable of solvolyzing the orthoborate esters to form a third mixture including the boron-containing compound(s), the alcohol and the tocopherol and/or sterol compound(s); and recovering the tocopherol and/or sterol compound(s). Another process for purifying such compounds includes an activated carbon treatment, which may alternatively follow the other process steps; formation of borate esters; heating to remove low boiling point components; formation of a residue comprising the borate esters; contacting the residue with a compound capable of solvolyzing the borate esters; and separation of the remaining components. Compositions including mixtures of alkyl/tocopherol/sterol orthoborate esters are also disclosed.

    Abstract translation: 公开了用于纯化化合物的方法，其包括使（i）至少一种生育酚化合物或固醇化合物的混合物和具有约10至30个碳的醇与（ii）一种或多种含硼化合物反应以形成第二混合物 的正硼酸酯，其中生育酚，固醇和醇与硼的摩尔比为至少约2.5:1; 加热第二混合物以形成含有原硼酸酯的残余物; 使残余物与能够使原硼酸酯溶剂化的化合物接触以形成包含含硼化合物，醇和生育酚和/或固醇化合物的第三混合物; 并回收生育酚和/或固醇化合物。 净化这些化合物的另一种方法包括活性炭处理，其可以替代地遵循其它工艺步骤; 形成硼酸酯; 加热去除低沸点组分; 形成含有硼酸酯的残渣; 使残余物与能够溶解硼酸酯的化合物接触; 并分离其余组分。 还公开了包括烷基/生育酚/正硼酸甾醇酯的混合物的组合物。

Patent Agency Ranking