公开(公告)号：US06626855B1

公开(公告)日：2003-09-30

申请号：US09721526

申请日：2000-11-22

申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

IPC分类号： A61N700

CPC分类号： A61N7/00 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B8/546 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0052

摘要： An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.

摘要翻译： 用于成像和递送高强度超声能量治疗到治疗部位的超声系统以及用超声波装置治疗患者体内的肿瘤和其它不需要的组织的方法。 超声波装置具有设置在细长相对薄的轴的远端上的超声换能器阵列。 在本发明的一种形式中，换能器阵列设置在液体填充的弹性体材料内，其更有效地将超声能量耦合到与装置直接接触的肿瘤中。 以连续波模式使用该装置，可以通过控制至少一个f号码，来产生具有期望大小和形状的组织的坏死区（例如，被选择用于中断向肿瘤供血的坏死体积） 持续时间，强度和方向。 这种方法加快了治疗速度，避免了持续暂停，从而使正常组织能够平静地冷却。

公开(公告)号：US06432067B1

公开(公告)日：2002-08-13

申请号：US09390032

申请日：1999-09-03

申请人： Roy W. Martin ,  Lawrence A. Crum ,  Shahram Vaezy ,  Stephen J. Carter ,  W. Scott Helton ,  Michael Gaps ,  Peter J. Kaczkowski ,  Andrew Proctor ,  George Keilman

发明人： Roy W. Martin ,  Lawrence A. Crum ,  Shahram Vaezy ,  Stephen J. Carter ,  W. Scott Helton ,  Michael Gaps ,  Peter J. Kaczkowski ,  Andrew Proctor ,  George Keilman

IPC分类号： A61N700

CPC分类号： A61B17/22004 ,  A61B8/14 ,  A61B8/4209 ,  A61B8/4218 ,  A61B8/4254 ,  A61B8/4281 ,  A61B8/4461 ,  A61B17/2251 ,  A61B17/2255 ,  A61B17/320068 ,  A61B17/320092 ,  A61B90/50 ,  A61B2017/12004 ,  A61B2017/22008 ,  A61B2017/320052 ,  A61B2090/0472 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0069 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/027

摘要： Methods and apparatus for enabling substantially bloodless surgery and for stemming hemorrhaging. High intensity focused ultrasound (“HIFU”) is used to form cauterized tissue regions prior to surgical incision, for example, forming a cauterized tissue shell around a tumor to be removed. The procedure is referred to as “presurgical volume cauterization.” In one embodiment, the method is particularly effective for use in surgical lesion removal or resection of tissue having a highly vascularized constitution, such as the liver or spleen, and thus a propensity for hemorrhaging. In further embodiments, methods and apparatus for hemostasis using HIFU is useful in both surgical, presurgical, and medical emergency situations. In an apparatus embodiment, a telescoping, acoustic coupler is provided such that depth of focus of the HIFU energy is controllable. In other embodiments, apparatus characterized by portability are demonstrated, useful for emergency medical situations.

摘要翻译： 用于实质上无血的手术和用于阻止出血的方法和装置。 高强度聚焦超声（“HIFU”）用于在手术切口之前形成烧灼的组织区域，例如，在要移除的肿瘤周围形成烧灼的组织壳。 该手术被称为“术前体积烧灼”。 在一个实施方案中，该方法特别有效地用于手术损伤去除或切除具有高度血管化构成的组织，例如肝脏或脾脏，并因此用于出血倾向。 在另外的实施例中，使用HIFU止血的方法和装置在外科手术，手术前和医疗紧急情况下都是有用的。 在设备实施例中，提供伸缩式声学耦合器，使得HIFU能量的焦深可以控制。 在其他实施例中，证明了便携性特征的装置，用于紧急医疗情况。

公开(公告)号：US06361510B1

公开(公告)日：2002-03-26

申请号：US09623417

申请日：2000-09-19

申请人： Giovanni Zanini

发明人： Giovanni Zanini

IPC分类号： A61N700

CPC分类号： A61N7/00

摘要： Decompression sickness in human patients is treated by administering to the patient in the region affected by decompression sickness ultrasound energy having a frequency in the range of 1 to 15 MHz in an amount and time sufficient to alleviate the symptoms of decompression sickness.

摘要翻译： 人体患者的减压病通过对患有在1〜15MHz范围内的减压病超声能量受影响的区域的患者进行治疗，其量和时间足以减轻减压症状。

公开(公告)号：US06254625B1

公开(公告)日：2001-07-03

申请号：US09109452

申请日：1998-07-02

申请人： Cenayda V. Rosenthal ,  Richard A. Rosenthal

发明人： Cenayda V. Rosenthal ,  Richard A. Rosenthal

IPC分类号： A61N700

CPC分类号： A61N5/0624 ,  A61L2/10 ,  A61N5/0616 ,  A61N2005/0654 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662

摘要： A hand sanitizer generally includes an ozone producing, germicidal ultraviolet lamp for oxidizing organic debris and inactivating bacteria and viruses on the surface and subsurface of hands. In addition, a polychromatic light source is provided for destruction of residual ozone and photoreactivating, or photorepairing, ultraviolet induced effects on the skin. The lamps may be disposed in a free standing housing having a chamber for containing the produced ozone and receiving hands in a vertical orientation. Fans may be provided for circulating the ozone and atmospheric gas throughout the chamber and for evaporating residual moisture from the skin. A light source for destroying excess ozone is also provided which may be operated after the organic debris has been oxidized. Shields are provided within the chamber in order to protect a user's eyes from exposure to the ultraviolet light. The apparatus may be powered entirely by conventional solar panels.

摘要翻译： 手部消毒剂通常包括用于氧化有机物的臭氧产生杀菌紫外线灯，并使手表面和地下的细菌和病毒灭活。 另外，提供了一种多色光源，用于破坏残留臭氧和光激活，或光修复紫外线对皮肤的影响。 灯可以设置在具有用于容纳所产生的臭氧并且以垂直取向接收手的室的独立式壳体中。 可以提供风扇以使整个室中的臭氧和大气气体循环并且从皮肤中蒸发残留的水分。 还提供了用于破坏过量臭氧的光源，其可在有机碎片被氧化之后进行操作。 为了保护使用者的眼睛免受紫外线的照射，在室内设置护罩。 该设备可以由传统的太阳能电池板完全供电。

公开(公告)号：US06736784B1

公开(公告)日：2004-05-18

申请号：US10018805

申请日：2002-05-06

申请人： Andreas Menne ,  Thomas Jerger

发明人： Andreas Menne ,  Thomas Jerger

IPC分类号： A61N700

CPC分类号： A61B17/225 ,  A61B17/22004 ,  G10K11/22 ,  G10K11/24

摘要： A medical instrument for treating biological tissue comprises a housing (2), a pressure wave generation means (4) and a transmission means (8) for coupling the unfocused pressure waves into the body of living beings. The transmission means (8) comprises a pressure chamber (12) having an inlet and an outlet end, the pressure chamber (12) containing a liquid (14) into which pressure waves from the pressure wave generation means (4) can be coupled, which pressure waves can be transmitted to a membrane (16) arranged at the outlet end of the pressure chamber (12) which membrane (16) couples the pressure waves transmitted from the liquid unfocusedly into the biological tissue.

摘要翻译： 用于治疗生物组织的医疗器械包括壳体（2），压力波产生装置（4）和用于将未聚焦的压力波耦合到生物体中的传播装置（8）。 传动装置（8）包括具有入口和出口端的压力室（12），压力室（12）包含液体（14），来自压力波发生装置（4）的压力波可与其连接， 哪个压力波可以传递到布置在压力室（12）的出口端处的膜（16），膜（16）将从未聚焦的液体传输的压力波耦合到生物组织中。

公开(公告)号：US06716184B2

公开(公告)日：2004-04-06

申请号：US10166795

申请日：2002-06-07

申请人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  George W. Keilman ,  Victor Y. Fujimoto ,  Lawrence A. Crum

发明人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  George W. Keilman ,  Victor Y. Fujimoto ,  Lawrence A. Crum

IPC分类号： A61N700

CPC分类号： A61B8/4488 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4209 ,  A61B8/4254 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61B8/483 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02

摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.

摘要翻译： 用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。 该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。 在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。 一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。 每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。 随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。 因此肿瘤最终将被破坏。 在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。 可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

公开(公告)号：US06361509B1

公开(公告)日：2002-03-26

申请号：US09465996

申请日：1999-12-17

申请人： Thomas Reuner

发明人： Thomas Reuner

IPC分类号： A61N700

CPC分类号： A61B17/2258 ,  A61B2018/2025 ,  A61N7/00

摘要： A therapy apparatus has a source with an acoustic axis for generating acoustic waves converging in a focus lying on the acoustic axis. The source has a light generator that emits a focused light beam of visible light with a substantially parallel beam path that substantially coincides with the acoustic axis of the source and makes it visible.

摘要翻译： 治疗装置具有用于产生聚焦在位于声轴上的焦点的声波的声轴的源。 源具有光发生器，其发射可见光的聚焦光束，其具有基本上与源的声轴重合并使其可见的基本平行的光束路径。

公开(公告)号：US06340352B1

公开(公告)日：2002-01-22

申请号：US09427021

申请日：1999-10-25

申请人： Mitsumasa Okada ,  Toshiya Sugai ,  Yoshitaka Honda ,  Manabu Ishikawa ,  Tomohisa Sakurai

发明人： Mitsumasa Okada ,  Toshiya Sugai ,  Yoshitaka Honda ,  Manabu Ishikawa ,  Tomohisa Sakurai

IPC分类号： A61N700

CPC分类号： A61B17/320092 ,  A61B18/1445 ,  A61B18/1482 ,  A61B2017/2929 ,  A61B2017/320072 ,  A61B2017/320084 ,  A61B2017/320088 ,  A61B2217/005 ,  A61B2217/007

摘要： An ultrasound treatment system in accordance with the present invention includes: ultrasonic transducers for generating ultrasonic vibrations; a handpiece including the ultrasonic transducers and serving as an operation unit; a probe connected to the ultrasonic transducers and serving as a vibration conveyer for conveying ultrasonic transducers to a distal member constituting a stationary section of a treatment unit used to treat a living tissue; a sheath serving as a protective member for shielding the probe; a holding member opposed to the distal member at the distal end of the sheath and constituting a movable section of the treatment unit which clamps a living tissue in cooperation with the distal member; a manipulator to be handled for clamping or freeing a living tissue using the holding member and distal member; an operation member for driving the holding member responsively to a movement of the manipulator; and a turning mechanism for turning the treatment unit relative to the manipulator with the axial direction of the ultrasonic transducers as a center.

摘要翻译： 根据本发明的超声波处理系统包括：用于产生超声波振动的超声波换能器; 包括超声波换能器并用作操作单元的手持件; 连接到所述超声换能器并用作用于将超声波换能器输送到构成用于治疗活组织的治疗单元的静止部分的远端构件的振动输送器的探针; 护套，用作用于屏蔽探针的保护构件; 在所述鞘的前端与所述远侧构件相对的构成所述处理单元的可动部的保持构件，其与所述远端构件配合地夹持活体组织; 用于使用所述保持构件和所述远端构件夹紧或释放生物体组织的操纵器; 操作构件，用于响应于所述操纵器的移动来驱动所述保持构件; 以及以超声波换能器的轴向为中心使处理单元相对于机械手转动的转动机构。

公开(公告)号：US06273864B1

公开(公告)日：2001-08-14

申请号：US09273221

申请日：1999-03-19

申请人： Luiz R. Duarte ,  Roger J. Talish

发明人： Luiz R. Duarte ,  Roger J. Talish

IPC分类号： A61N700

CPC分类号： A61N7/00 ,  A61N2007/0017

摘要： A portable therapeutic device and method of use generate longitudinally propagating ultrasound and shear waves generated by such longitudinally propagating ultrasound to provide effective healing of wounds. A transducer having an operative surface is disposed substantially adjacent to the wound to emit ultrasound to propagate in the direction of the wound to promote healing. Reflections of the ultrasound by bone tissue, by skin layers, or by internally disposed reflective media propagate toward the wound as longitudinal waves, with shear waves generated by the longitudinal waves for the healing of the wound. A focusing element is used for focusing the propagation of the ultrasound at a predetermined angle toward the wound. The operative surface of the transducer may be annularly shaped to encircle the wound to convey the ultrasound and/or reflected ultrasound thereto. A housing may be provided for positioning the transducer near a portion of the skin near the wound, and for indenting the skin to form a cavity, with the transducer disposed in the cavity to emit the ultrasound toward an internal surface of the wound. Fixture structures, such as adjustable straps, may extend about a portion of the body to position the transducer near the wound.

摘要翻译： 便携式治疗装置和使用方法产生由这种纵向传播的超声波产生的纵向传播的超声波和剪切波，以提供伤口的有效愈合。 具有操作表面的换能器基本上邻近伤口设置以发射超声波以沿伤口的方向传播以促进愈合。 通过骨组织，皮肤层或内部设置的反射介质对超声波的反射作为纵波传播到伤口，由纵波产生的剪切波用于伤口的愈合。 聚焦元件用于将超声波以预定角度的传播聚焦到伤口。 换能器的操作表面可以是环形的以包围伤口以将超声波和/或反射超声波传送到其上。 可以提供壳体，用于将换能器靠近伤口附近的皮肤的一部分定位，并且用于压缩皮肤以形成空腔，换能器设置在空腔中以朝向伤口的内表面发射超声波。 诸如可调节带的夹具结构可以围绕身体的一部分延伸以将换能器定位在伤口附近。

公开(公告)号：US06413230B1

公开(公告)日：2002-07-02

申请号：US09446097

申请日：2000-02-22

申请人： Gerald Haupt ,  Andreas Menne ,  Manfred Schulz

发明人： Gerald Haupt ,  Andreas Menne ,  Manfred Schulz

IPC分类号： A61N700

CPC分类号： G10K15/043 ,  A61B17/2251 ,  A61B17/56 ,  A61B2017/00544 ,  A61B2017/924 ,  A61B2017/927 ,  A61H23/008 ,  A61H23/04 ,  A61N7/00

摘要： The invention relates to a medical instrument for treating biological tissue, comprising a device for generating extra-corporeal pressure waves and a transmission element (2) for injecting pressure waves into the bodies of living organisms. According to the invention the transmission element (2) has a blunt probe tip (22) with a flat exit surface (24) which injects non-focused mechanically generated pressure waves into the biological tissue.

摘要翻译： 本发明涉及一种用于治疗生物组织的医疗器械，包括用于产生超体外压力波的装置和用于将压力波注入生物体的体内的传播元件（2）。 根据本发明，传输元件（2）具有钝的探针尖端（22），其具有平坦的出射表面（24），其将非聚焦的机械产生的压力波注入到生物组织中。