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    Ultrasonic catheter power control
    5.
    发明授权
    Ultrasonic catheter power control 有权
    超声波导管功率控制

    公开(公告)号：US08852166B1

    公开(公告)日：2014-10-07

    申请号：US13528735

    申请日：2012-06-20

    申请人： George Keilman ,  Douglas R. Hansmann ,  Azita Soltani ,  Richard R. Wilson

    发明人： George Keilman ,  Douglas R. Hansmann ,  Azita Soltani ,  Richard R. Wilson

    IPC分类号： A61M31/00

    CPC分类号： A61M37/0092 ,  A61B17/320068

    摘要： A method of treating an occlusion at a treatment site within a patient's vasculature comprises providing an ultrasonic catheter. The ultrasonic catheter has a distal region, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region. The method further comprises positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion. The ultrasonic catheter further comprises passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site. The ultrasonic catheter further comprises emitting ultrasonic energy from the ultrasound radiating member. The emitted ultrasonic energy has an amplitude that is periodically varied between a low amplitude and a high amplitude.

    摘要翻译： 治疗患者脉管系统内的治疗部位的闭塞的方法包括提供超声导管。 超声波导管具有远端区域，与远端区域相对的近端区域，具有远端区域中的至少一个开口的流体输送腔和位于远侧区域内的超声波辐射构件。 该方法还包括将超声波导管定位在治疗部位，使得远侧区域的至少一部分在咬合内。 超声波导管还包括使治疗化合物通过流体输送腔，使得治疗化合物被递送至治疗部位。 超声波导管还包括从超声波辐射构件发射超声波能量。 发射的超声能量具有在低振幅和高振幅之间周期性变化的幅度。

    MEMS pressure sensor and housing therefor
    8.
    发明授权
    MEMS pressure sensor and housing therefor 有权
    MEMS压力传感器及其壳体

    公开(公告)号：US08033177B2

    公开(公告)日：2011-10-11

    申请号：US12367689

    申请日：2009-02-09

    申请人： George Keilman ,  Tim Johnson

    发明人： George Keilman ,  Tim Johnson

    IPC分类号： G01L9/12

    CPC分类号： G01L19/0084 ,  G01L9/0073 ,  G01L19/0645

    摘要： A pressure sensing system positions a microelectromechanical (MEMS) diaphragm of a MEMS pressure sensor die in a housing to indirectly sample pressure state of a fluid being measured. A second housing diaphragm is used to make direct contact with the fluid being measured. Pressure state of the fluid being measured is transferred from the housing diaphragm through an electrically insulating intermediary fluid to the MEMS diaphragm thereby allowing the MEMS pressure sensor die to indirectly sample pressure state of the fluid being measured. Electrically conductive support members and electrically conductive solid vias are used to electrically couple circuitry of the MEMS pressure sensor die to external wires outside the housing.

    摘要翻译： 压力感测系统将MEMS压力传感器管芯的微机电（MEMS）隔膜定位在壳体中以间接采样被测流体的压力状态。 第二壳体隔膜用于与正在测量的流体直接接触。 被测量的流体的压力状态从壳体隔膜通过电绝缘中间流体传递到MEMS隔膜，从而允许MEMS压力传感器模具间接地对被测流体的压力状态进行采样。 导电支撑构件和导电固体通孔用于将MEMS压力传感器管芯的电路电耦合到壳体外部的外部电线。

    PRESSURE SENSING SYSTEM AND METHOD
    9.
    发明申请
    PRESSURE SENSING SYSTEM AND METHOD 有权
    压力传感系统及方法

    公开(公告)号：US20090205432A1

    公开(公告)日：2009-08-20

    申请号：US12367689

    申请日：2009-02-09

    申请人： George Keilman ,  Tim Johnson

    发明人： George Keilman ,  Tim Johnson

    IPC分类号： G01L9/12 ,  G01L9/06

    CPC分类号： G01L19/0084 ,  G01L9/0073 ,  G01L19/0645

    摘要： A pressure sensing system positions a microelectromechanical (MEMS) diaphragm of a MEMS pressure sensor die in a housing to indirectly sample pressure state of a fluid being measured. A second housing diaphragm is used to make direct contact with the fluid being measured. Pressure state of the fluid being measured is transferred from the housing diaphragm through an electrically insulating intermediary fluid to the MEMS diaphragm thereby allowing the MEMS pressure sensor die to indirectly sample pressure state of the fluid being measured. Electrically conductive support members and electrically conductive solid vias are used to electrically couple circuitry of the MEMS pressure sensor die to external wires outside the housing.

    摘要翻译： 压力感测系统将MEMS压力传感器管芯的微机电（MEMS）隔膜定位在壳体中以间接采样被测流体的压力状态。 第二壳体隔膜用于与正在测量的流体直接接触。 被测量的流体的压力状态从壳体隔膜通过电绝缘中间流体传递到MEMS隔膜，从而允许MEMS压力传感器模具间接地对被测流体的压力状态进行采样。 导电支撑构件和导电固体通孔用于将MEMS压力传感器管芯的电路电耦合到壳体外部的外部电线。

    Catheter with multiple ultrasound radiating members
    10.
    发明授权
    Catheter with multiple ultrasound radiating members 有权
    导管与多个超声波辐射构件

    公开(公告)号：US07828762B2

    公开(公告)日：2010-11-09

    申请号：US11643417

    申请日：2006-12-21

    申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

    发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

    IPC分类号： A61B17/20

    CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

    摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

    摘要翻译： 用于将超声能量和治疗性化合物递送到患者脉管系统内的治疗部位的导管包括管状体。 管状体具有近端区域和与近端区域相对的远端区域。 导管还包括形成在管状体中的多个流体输送腔。 该导管还包括构造成用于插入管状体的内芯。 内芯包括具有多个扁平区域的细长电导体，每个扁平区域具有第一平坦侧和与第一平坦侧相对的第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 导管还包括配置成将驱动信号施加到超声辐射构件的至少两个但是少于全部的控制电子设备。