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    Methods to deliver high intensity focused ultrasound to target regions proximate blood vessels
    1.
    发明授权
    Methods to deliver high intensity focused ultrasound to target regions proximate blood vessels 有权
    将高强度聚焦超声波提供给目标血管附近的方法

    公开(公告)号：US08137274B2

    公开(公告)日：2012-03-20

    申请号：US13025959

    申请日：2011-02-11

    申请人： Lee Weng ,  David M Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M Perozek ,  Jimin Zhang

    IPC分类号： A61B8/00

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： Methods for applying heat to a region proximate a blood vessel are disclosed. In one embodiment, a method can include generating an imaging ultrasound beam adapted to image a blood vessel target and receiving a reflection of the imaging ultrasound beam. The method can also include producing an output signal in response to the reflection of the imaging ultrasonic beam and processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel. Therapeutic energy can be applied to the treatment zone. In some embodiments, the therapeutic ultrasound energy beam can be moved to over-scan the treatment zone. Other methods are also disclosed.

    摘要翻译： 公开了向靠近血管的区域施加热量的方法。 在一个实施例中，一种方法可以包括产生适于对血管目标成像并接收成像超声波束的反射的成像超声波束。 该方法还可以包括响应于成像超声波束的反射而产生输出信号并且处理输出信号以识别靠近血管外壁的治疗区域的位置。 治疗能量可以应用于治疗区域。 在一些实施例中，治疗性超声能量束可以被移动以过度扫描治疗区域。 还公开了其它方法。

    METHODS AND APPARATUS FOR FOCUSED ULTRASOUND APPLICATION
    2.
    发明申请
    METHODS AND APPARATUS FOR FOCUSED ULTRASOUND APPLICATION 有权
    聚焦超声波应用的方法与装置

    公开(公告)号：US20110118602A1

    公开(公告)日：2011-05-19

    申请号：US13011533

    申请日：2011-01-21

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.

    摘要翻译： 超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。 耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。 旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在 穿刺部位。 该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。 描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

    FINDING PAIRED ISOTOPE GROUPS
    4.
    发明申请
    FINDING PAIRED ISOTOPE GROUPS 审中-公开
    找到配对的同位素组

    公开(公告)号：US20100310138A1

    公开(公告)日：2010-12-09

    申请号：US12663168

    申请日：2008-06-04

    申请人： Andrey Bondarenko ,  Alexander Spiridonov ,  Lee Weng

    发明人： Andrey Bondarenko ,  Alexander Spiridonov ,  Lee Weng

    IPC分类号： G06K9/62

    CPC分类号： G01N30/8675 ,  G01N30/7233 ,  G01N2030/8831

    摘要： A technique for finding paired isotope groups of peptides, metabolic materials, or other materials is executed without having to identify features. Any suitable isotopic labeling methods, such as SILAC or ICAT, can be used. The technique can identify isotope pairs by pairing heavy and light labeled peptides based on mono-isotopes. The technique searches for isotope groups that have retention time and mass/charge within given tolerances, adjustable by users. Multiple label sites are supported as well as reverse-labeling to inhibit or reduce biases. Multiple replicates can be merged into a composite image.

    摘要翻译： 执行肽，代谢材料或其他材料的配对同位素组的技术，而不必识别特征。 可以使用任何合适的同位素标记方法，例如SILAC或ICAT。 该技术可以通过配对基于单同位素的重和轻标记的肽来鉴定同位素对。 该技术搜索在给定公差范围内具有保留时间和质量/电荷的同位素组，可由用户调整。 支持多个标记位点以及反向标记以抑制或减少偏倚。 多个重复可以合并到合成图像中。

    Discover biological features using composite images
    5.
    发明申请
    Discover biological features using composite images 失效
    使用复合图像发现生物特征

    公开(公告)号：US20070211928A1

    公开(公告)日：2007-09-13

    申请号：US11599184

    申请日：2006-11-13

    申请人： Lee Weng ,  Andrey Bondarenko ,  Silvia Vega ,  Ernst Henle ,  Brandon Hunt ,  Alexander Spiridonov

    发明人： Lee Weng ,  Andrey Bondarenko ,  Silvia Vega ,  Ernst Henle ,  Brandon Hunt ,  Alexander Spiridonov

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0012 ,  G01N30/8624 ,  G01N30/8644 ,  G01N30/8675 ,  G01N30/8679 ,  G06K9/0014 ,  G06K9/46 ,  G06K9/6203 ,  G06T7/41 ,  G06T2207/20212 ,  G06T2207/30004 ,  Y10T436/24

    摘要： An image processing system extracts parts or characteristics of interest from prepared biological samples One suitable use of the image processing system is to find biomarkers. But many other suitable uses are possible. Some components of the system include image preprocessing (data interpolation, retention time alignment, image noise filtering, background estimation, and formation of a composite image); image feature extraction (peaks, isotope groups, and charge groups); and computation of feature characteristics and expression statistics, differential expression, and non-differential expression. Outputs of the system include a candidate list of parts or characteristic of interest for aiding further discovery.

    摘要翻译： 图像处理系统从制备的生物样品中提取感兴趣的部分或特征图像处理系统的一个合适的用途是找到生物标志物。 但是许多其他合适的用途是可能的。 系统的一些组件包括图像预处理（数据插值，保留时间对齐，图像噪声滤波，背景估计和合成图像的形成）; 图像特征提取（峰，同位素组和电荷组）; 特征特征和表达统计，微分表达和非差分表达的计算。 系统的输出包括用于辅助进一步发现的部分或特征的候选列表。

    Ultrasound transducers for imaging and therapy
    6.
    发明申请
    Ultrasound transducers for imaging and therapy 审中-公开
    用于成像和治疗的超声换能器

    公开(公告)号：US20060235300A1

    公开(公告)日：2006-10-19

    申请号：US11471052

    申请日：2006-06-19

    申请人： Lee Weng ,  David Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David Perozek ,  Jimin Zhang

    IPC分类号： A61B8/00 ,  A61H1/00

    CPC分类号： A61B8/4461 ,  A61B8/12 ,  A61B8/445 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61H23/0245 ,  A61N7/02 ,  A61N2007/0052 ,  A61N2007/0065 ,  A61N2007/0078 ,  G10K11/32 ,  G10K11/346

    摘要： Ultrasound applicators able to both image a treatment site and administer ultrasound therapy include an array of transducer elements that can be focused. In several embodiments, an electronically phased array is used for controlling the focal point of an ultrasound beam. The ultrasound beam produced thereby can also be electronically steered. To reduce the quality factor or Q of the array when the array is used for imaging, an electronic switch is selectively closed, placing a resistance in parallel with each of the array elements. A flexible array is employed in several embodiments and is selectively bent or flexed to vary its radius of curvature and thus control the focal point and/or a direction of focus of the array. In another embodiment, each of the transducer elements comprising the array are individually mechanically pivotable to steer the ultrasonic beam produced by the transducer elements.

    摘要翻译： 能够对治疗部位进行成像并进行超声治疗的超声波施加器包括可聚焦的换能器元件阵列。 在几个实施例中，电子相控阵列用于控制超声波束的焦点。 由此产生的超声波束也可以被电子控制。 为了在阵列用于成像时降低阵列的质量因子或Q，选择性地关闭电子开关，将电阻与每个阵列元件并联。 在几个实施例中使用柔性阵列并且被选择性地弯曲或弯曲以改变其曲率半径，并且因此控制阵列的焦点和/或焦点的方向。 在另一个实施例中，包括阵列的每个换能器元件分别机械地枢转以转向由换能器元件产生的超声波束。

    Use of focused ultrasound for vascular sealing
    8.
    发明授权
    Use of focused ultrasound for vascular sealing 有权
    使用聚焦超声波进行血管密封

    公开(公告)号：US06656136B1

    公开(公告)日：2003-12-02

    申请号：US09696076

    申请日：2000-10-25

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61H500

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： A method and system for locating a vascular opening and therapeutically sealing the wound with high intensity focused ultrasound (HIFU) is disclosed. A control unit (6) coupled to an applicator unit includes a processor (74) that automates the disclosed procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. The disclosed method and system is and then discarded, is slipped over the particularly applicable to sealing a puncture made inserting a catheter during an interventional cardiovascular procedure.

    摘要翻译： 公开了一种用于定位血管开口并用高强度聚焦超声（HIFU）治疗性密封伤口的方法和系统。 耦合到施加器单元的控制单元（6）包括处理器（74），其使所公开的过程自动化，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。 所公开的方法和系统然后被丢弃，特别适用于密封在介入性心血管程序期间插入导管的穿刺。

    Method and apparatus for generating and displaying panoramic ultrasound images
    10.
    发明授权
    Method and apparatus for generating and displaying panoramic ultrasound images 失效
    用于生成和显示全景超声图像的方法和装置

    公开(公告)号：US5782766A

    公开(公告)日：1998-07-21

    申请号：US747429

    申请日：1996-11-19

    申请人： Lee Weng ,  Arun P. Tirumalai ,  Levin Nock

    发明人： Lee Weng ,  Arun P. Tirumalai ,  Levin Nock

    IPC分类号： A61B8/08 ,  G01S7/52 ,  G01S15/89 ,  G06T7/20 ,  A61B8/00

    CPC分类号： A61B8/0866 ,  A61B8/463 ,  A61B8/483 ,  G01S15/8979 ,  G01S15/8993 ,  G01S7/5205 ,  G01S7/52074 ,  G06K9/32 ,  G06T7/2013 ,  G06T7/2026 ,  G06T7/2033 ,  A61B8/0833 ,  A61B8/4254 ,  G01S15/52 ,  G01S15/88 ,  G01S15/8934 ,  G01S15/8977 ,  G01S7/5206 ,  G01S7/52065 ,  G01S7/52068 ,  G01S7/52073 ,  G06K2009/2045 ,  G06T2207/10016 ,  G06T2207/10068 ,  G06T2207/30196 ,  Y10S128/916

    摘要： An image registration based method and a corresponding apparatus are provided for creating composite, panoramic images, in which consecutive ultrasonic image frames are correlated in order to derive transducer motion information. The individual images can be divided into several smaller sub-image regions and a fast and robust image motion detection algorithm is used to measure the sub-image motion and then to determine an initial estimation of the local motion vectors. The initial estimation is combined with two measurement parameters by use of a fuzzy logic technique to derive a final estimation of the local motion vectors. The final local motion vectors are then used to estimate global image motion. Compound images are then diplayed based on the derived global image motion. The speed of motion of the transducer is also estimated and a "speedometer" is displayed to help the user move the transducer within efficient speed ranges. Image frames may also be selectively "zoomed" in on and displayed in an undistorted manner. Distance scales are generated for both the normally curved panoramic image and also the undistorted frame images. A frame guide is also displayed to help the user guide the transducer to area of greatest interest. Color-coded velocity or power information may also be superimposed on the panoramic image, and spectral Doppler data may also be displayed at selected points in the panoramic image. A memory map is preferably also displayed to indicate to the user how much image memory is remaining during a scan.

    摘要翻译： 提供了基于图像注册的方法和相应的装置，用于创建复合全景图像，其中连续的超声图像帧被相关联以便导出换能器运动信息。 各个图像可以分成几个较小的子图像区域，并且使用快速和鲁棒的图像运动检测算法来测量子图像运动，然后确定局部运动矢量的初始估计。 通过使用模糊逻辑技术将初始估计与两个测量参数组合以得到局部运动矢量的最终估计。 然后使用最终的局部运动矢量来估计全局图像运动。 然后基于导出的全局图像运动显示复合图像。 还估计传感器的运动速度，并显示“速度计”，以帮助用户在有效的速度范围内移动换能器。 图像帧也可以被选择性地“放大”并且以未失真的方式显示。 对于正常弯曲的全景图像以及未失真的帧图像都产生距离刻度。 还显示框架指南，以帮助用户将传感器引导到最感兴趣的区域。 颜色编码的速度或功率信息也可以叠加在全景图像上，并且频谱多普勒数据也可以在全景图像的选定点处显示。 优选还显示存储器映射以向用户指示扫描期间剩余多少图像存储器。