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    Centroid processing
    1.
    发明授权
    Centroid processing 有权
    质心处理

    公开(公告)号：US08761465B2

    公开(公告)日：2014-06-24

    申请号：US12726927

    申请日：2010-03-18

    申请人： Brandon T. Hunt ,  Ernst S. Henle

    发明人： Brandon T. Hunt ,  Ernst S. Henle

    IPC分类号： G06K9/00

    CPC分类号： G06K9/6218 ,  H01J49/0036

    摘要： Hardware and software components are configured to image-process centroid data as if they were profile data to discover biological features. Proper mass/charge bin size are determined to raster centroid data into LC/MS images. To correct for the decrease in precision, the LC/MS images are re-evaluated in view of the original centroid data. Peak detection from the binned image is refined by re-considering the corresponding centroid data through cluster analysis. Additionally, some peaks that were merged through processing may be resolved into individual peaks by identifying more than one significant cluster masked by a peak from the binned image.

    摘要翻译： 硬件和软件组件被配置为对像素数据进行图像处理，就像它们是轮廓数据以发现生物特征一样。 确定适当的质量/充电箱尺寸以将光栅质心数据确定为LC / MS图像。 为了校正精度的降低，LC / MS图像根据原始质心数据进行重新评估。 通过聚类分析重新考虑相应的质心数据，从分类图像得到峰值检测。 另外，通过处理合并的一些峰值可以通过识别由分组图像的峰值屏蔽的多于一个的有效群集而被分解成各个峰值。

    NON-CONTIGUOUS REGIONS PROCESSING
    2.
    发明申请
    NON-CONTIGUOUS REGIONS PROCESSING 有权
    非连续区域处理

    公开(公告)号：US20100106460A1

    公开(公告)日：2010-04-29

    申请号：US12421562

    申请日：2009-04-09

    申请人： Ernst S. Henle ,  Brandon T. Hunt

    发明人： Ernst S. Henle ,  Brandon T. Hunt

    IPC分类号： G06F15/00 ,  H01J49/26

    CPC分类号： G06K9/3233 ,  G06K9/6203

    摘要： Non-contiguous regions of interest as well as contiguous regions of interest are similarly processed. After an isotope peak detector has identified isotope peaks on LC/MS images, a microaligner microaligns bounding areas of identified isotope peaks and redefines the bounding areas to help subsequent scoring process. Forms of isotope peaks influence formation of a peak association matrix and a mass/charge association map which creates association in the mass/charge dimension. A correlation scorer produces reproducibility scores as well as quality scores to help aid scientists to discover biological features of interest.

    摘要翻译： 类似地处理非连续的感兴趣区域以及连续的感兴趣区域。 在同位素峰检测器已经在LC / MS图像上鉴定出同位素峰之后，微标记物微分界定识别的同位素峰的区域，并重新界定了界限区域以帮助随后的评分过程。 同位素峰的形式影响峰关联矩阵的形成和质量/电荷关联图，其在质量/电荷维度中产生缔合。 相关记分仪产生重现性分数以及质量分数，以帮助科学家发现感兴趣的生物学特征。

    Peak reassembly
    4.
    发明授权
    Peak reassembly 失效
    峰值重组

    公开(公告)号：US08260015B2

    公开(公告)日：2012-09-04

    申请号：US12313222

    申请日：2008-11-17

    申请人： Ernst S. Henle ,  Brandon T. Hunt

    发明人： Ernst S. Henle ,  Brandon T. Hunt

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127

    摘要： In differential and non-differential analyses, composite images derived from replicates of liquid-chromatography/mass-spectrometry processes can provide scientists with a better signal-to-noise ratio in discovering biological features of interest. Certain distinct peaks in composite images point to distinct biological features but some distinct peaks in composite images may also point to biological features that have common chemical species ancestry. A peak reassembly process is used to indicate whether two adjacent peaks should point to a biological feature using complementation analysis and collision analysis.

    摘要翻译： 在微分和非差分分析中，由液相色谱/质谱法复制得到的复合图像可以为科学家提供更好的信噪比，从而发现感兴趣的生物学特征。 复合图像中的某些不同的峰指向不同的生物学特征，但合成图像中的一些不同的峰也可能指向具有共同的化学物种祖先的生物学特征。 峰值重组过程用于指示两个相邻峰值是否应使用互补分析和碰撞分析指向生物特征。

    CENTROID PROCESSING
    6.
    发明申请
    CENTROID PROCESSING 有权
    中心加工

    公开(公告)号：US20100239139A1

    公开(公告)日：2010-09-23

    申请号：US12726927

    申请日：2010-03-18

    申请人： Brandon T. Hunt ,  Ernst S. Henle

    发明人： Brandon T. Hunt ,  Ernst S. Henle

    IPC分类号： G06K9/00

    CPC分类号： G06K9/6218 ,  H01J49/0036

    摘要： Hardware and software components are configured to image-process centroid data as if they were profile data to discover biological features. Proper mass/charge bin size are determined to raster centroid data into LC/MS images. To correct for the decrease in precision, the LC/MS images are re-evaluated in view of the original centroid data. Peak detection from the binned image is refined by re-considering the corresponding centroid data through cluster analysis. Additionally, some peaks that were merged through processing may be resolved into individual peaks by identifying more than one significant cluster masked by a peak from the binned image.

    摘要翻译： 硬件和软件组件被配置为对像素数据进行图像处理，就像它们是轮廓数据以发现生物特征一样。 确定适当的质量/充电箱尺寸以将光栅质心数据确定为LC / MS图像。 为了校正精度的降低，LC / MS图像根据原始质心数据进行重新评估。 通过聚类分析重新考虑相应的质心数据，从分类图像得到峰值检测。 另外，通过处理合并的一些峰值可以通过识别由分组图像的峰值屏蔽的多于一个的有效群集而被分解成各个峰值。

    Iterative processing
    7.
    发明授权
    Iterative processing 失效
    迭代处理

    公开(公告)号：US08532348B2

    公开(公告)日：2013-09-10

    申请号：US12605280

    申请日：2009-10-23

    申请人： Brandon T. Hunt ,  Ernst S. Henle

    发明人： Brandon T. Hunt ,  Ernst S. Henle

    IPC分类号： G06K9/00

    CPC分类号： G06K9/3233 ,  G06K9/6203

    摘要： A regional redefiner redefines a bounding area in sets of chromatographic/mass spectroscopic images. The redefiner defines and localizes peaks in the images which point to a common feature of interest. A redefined bounding area locates other peaks associated with the feature of interest. Peaks can be iteratively identified and extracted using constituent images or a composite image formed as a combination of a set of constituent images.

    摘要翻译： 区域重新定义重新定义了一组色谱/质谱图像中的边界区域。 重新定义器定义并定位图像中的峰值，其指向感兴趣的共同特征。 重新定义的边界区域定位与感兴趣特征相关联的其他峰值。 可以使用构成图像或形成为一组构成图像的组合的合成图像来迭代地识别和提取峰。

    Regions of interest processing
    8.
    发明授权
    Regions of interest processing 失效
    感兴趣区域处理

    公开(公告)号：US08254651B2

    公开(公告)日：2012-08-28

    申请号：US12605277

    申请日：2009-10-23

    申请人： Brandon T. Hunt ,  Ernst S. Henle ,  Andrey Bondarenko

    发明人： Brandon T. Hunt ,  Ernst S. Henle ,  Andrey Bondarenko

    IPC分类号： G06K9/00 ,  G01N33/53

    CPC分类号： G06K9/3233 ,  G06K9/6203

    摘要： After prepared biological samples have been submitted to liquid-chromatography/mass spectrometry equipment, digital images are produced that show variations. Some of these variations may be of interest while others are not of interest. Variations in regions of interest can be correlated and correlation scores produced to classify biological features aid in scientific discovery. Shape properties of variations can also be calculated by geometric scores. A microalignment method aids the correlation calculation without resorting to macroalignment.

    摘要翻译： 制备的生物样品已经提交到液相色谱/质谱设备后，产生显示变化的数字图像。 这些变化中的一些可能是有意义的，而另一些不是有意义的。 感兴趣区域的变化可以相关，并且为生物特征分类而产生的相关分数有助于科学发现。 变异的形状属性也可以通过几何分数计算。 微分方法有助于相关计算，而不需要进行宏观调整。

    Non-contiguous regions processing
    10.
    发明授权
    Non-contiguous regions processing 有权
    非连续区域处理

    公开(公告)号：US08321144B2

    公开(公告)日：2012-11-27

    申请号：US12421562

    申请日：2009-04-09

    申请人： Ernst S. Henle ,  Brandon T. Hunt

    发明人： Ernst S. Henle ,  Brandon T. Hunt

    IPC分类号： G01N33/50 ,  G01N33/48

    CPC分类号： G06K9/3233 ,  G06K9/6203

    摘要： Non-contiguous regions of interest as well as contiguous regions of interest are similarly processed. After an isotope peak detector has identified isotope peaks on LC/MS images, a microaligner microaligns bounding areas of identified isotope peaks and redefines the bounding areas to help subsequent scoring process. Forms of isotope peaks influence formation of a peak association matrix and a mass/charge association map which creates association in the mass/charge dimension. A correlation scorer produces reproducibility scores as well as quality scores to help aid scientists to discover biological features of interest.

    摘要翻译： 类似地处理非连续的感兴趣区域以及连续的感兴趣区域。 在同位素峰检测器已经在LC / MS图像上鉴定出同位素峰之后，微标记物微分界定识别的同位素峰的区域，并重新界定了界限区域以帮助随后的评分过程。 同位素峰的形式影响峰关联矩阵的形成和质量/电荷关联图，其在质量/电荷维度中产生缔合。 相关记分仪产生重现性分数以及质量分数，以帮助科学家发现感兴趣的生物学特征。