公开(公告)号：US20240325478A1

公开(公告)日：2024-10-03

申请号：US18621062

申请日：2024-03-28

Applicant: Ningxia Medical University ,  Ningxia Freedom Biological Pharmaceutical Technology Co., LTD

Inventor： Rui He ,  Guangyong Li ,  Xiaojiang Chen ,  Xiaoli Du ,  Xiangdong Zhu ,  Huiming Ma ,  Miao Sun ,  Jiafuruzi He

IPC: A61K36/232 ,  A61K36/076 ,  A61K36/185 ,  A61K36/235 ,  A61K36/236 ,  A61K36/24 ,  A61K36/284 ,  A61K36/344 ,  A61K36/48 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/62 ,  A61K36/67 ,  A61K36/714 ,  A61K36/754 ,  A61K36/894 ,  A61K36/9062 ,  A61K36/9068 ,  A61P15/08

CPC classification number: A61K36/232 ,  A61K36/076 ,  A61K36/185 ,  A61K36/235 ,  A61K36/236 ,  A61K36/24 ,  A61K36/284 ,  A61K36/344 ,  A61K36/48 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/62 ,  A61K36/67 ,  A61K36/714 ,  A61K36/754 ,  A61K36/894 ,  A61K36/9062 ,  A61K36/9068 ,  A61P15/08 ,  A61K2236/331

Abstract: A traditional Chinese medicine compound for improving testicular dysfunction is made from the following raw materials: Codonopsis pilosula, Astragalus membranaceus, Dioscorea opposita, Angelica sinensis, Atractylodes macrocephala, Poria cocos, Cynanchum otophyllum, Psoralea corylifolia, Ligusticum chuanxiong, Nelumbo nucifera, Euryale ferox, Amomum villosum, Alpinia katsumadai, Foeniculum vulgare, Cinnamomum cassia, Evodia ruticarpa, Piper nigrum, Zingiber officinale, Aconitum carmichaelii, and Glycyrrhiza uralensis. All the raw materials are combined, so that the spleen, the stomach and the kidney are in harmony, the qi, the blood and the body fluid are recovered, and the kidney essence is active. Animal experiments show that the traditional Chinese medicine compound can up-regulate expressions of phosphatidylinositol 3-kinase (PI3K), phospho-protein kinase B (p-AKT) and B-cell lymphoma-2 (Bcl-2), improve testicular dysfunction, improve hormone secretion, regulate a male reproductive endocrine environment of the body, and further improve semen parameters.

公开(公告)号：US20210213034A1

公开(公告)日：2021-07-15

申请号：US17058924

申请日：2019-05-24

Applicant: NEURALIA

Inventor： Noëlle CALLIZOT

IPC: A61K31/58 ,  A61K31/192 ,  A61K36/894 ,  A61K36/8965 ,  A61K36/90 ,  A61K36/48 ,  A23L33/105 ,  A61P25/28

Abstract: A combination composition including as active components, in synergistically effective amounts of (i) a steroidal saponin of natural or synthetic origin, a pharmaceutical acceptable salt thereof or a plant extract containing steroidal saponin, and (ii) at least a first polyphenolic compound selected from the group of hydroxycinnamic acids, flavonoids, hydroxybenzoic acids, and (iii) optionally, a second polyphenolic compound, wherein the second polyphenolic compound is hydroxycinnamic acids and its use in preventing, inhibiting, retarding or treating a subject suffering from a neurodegenerative disease or condition.

公开(公告)号：US20170313739A1

公开(公告)日：2017-11-02

申请号：US15653397

申请日：2017-07-18

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Susan L. MOOBERRY ,  Jiangnan PENG ,  April L. RISINGER ,  Jing LI

IPC: C07J71/00 ,  C07D493/08 ,  A61K36/894 ,  A61K31/585

CPC classification number: C07J71/001 ,  A61K31/585 ,  A61K36/894 ,  C07D493/08 ,  C07J71/0005

Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.

公开(公告)号：US20110033556A1

公开(公告)日：2011-02-10

申请号：US12793958

申请日：2010-06-04

Applicant: Zheming Jin ,  Xitian Zhang

Inventor： Zheming Jin ,  Xitian Zhang

IPC: A61K36/481 ,  A61K36/282 ,  A61K36/18 ,  A61K36/28 ,  A61K35/56 ,  A61K36/258 ,  A61K36/482 ,  A61K36/484 ,  A61K36/605 ,  A61K36/8969 ,  A61K36/815 ,  A61K36/074 ,  A61K36/65 ,  A61K36/537 ,  A61K36/894 ,  A61K36/748 ,  A61K36/804 ,  A61K35/64 ,  A61K36/906 ,  A61K36/884 ,  A61K36/23 ,  A61K36/704 ,  A61K36/90 ,  A61K36/355 ,  A61K36/81 ,  A61K36/428 ,  A61K36/536 ,  A61K36/539 ,  A61K35/38 ,  A61K36/16 ,  A61K36/535 ,  A61K36/71 ,  A61K36/63 ,  A61P31/14 ,  A61P31/20 ,  A61P31/06 ,  A61P31/18 ,  A61P29/00 ,  A61P1/16

CPC classification number: A61K36/00

Abstract: A natural pharmaceutical preparation for treating hypoproteinemia, includes at least one member selected from the group consisting of a drug of increasing human serum albium, a drug of improving and enhance immunity, a drug of treating hepatitis B, a drug of treating Hepatitis C, a drug of treating acquired immune deficiency syndrome (AIDS), a drug of treating Tuberculosis, a drug of treat Fibrosis, a drug of treating hydrothorax, a drug of easing pain, a drug of stopping diarrhea, a drug of arresting coughing, a drug of reducing inflammation, and a drug of increasing urine.

Abstract translation: 一种用于治疗低蛋白血症的天然药物制剂，包括至少一种选自增加人血清白蛋白的药物，改善和增强免疫力的药物，治疗乙型肝炎的药物，治疗丙型肝炎的药物，a 治疗获得性免疫缺陷综合征（AIDS）的药物，治疗结核病的药物，治疗性纤维化药物，治疗胸水的药物，缓解疼痛的药物，停止腹泻的药物，止咳药的药物 减少炎症，增加尿液的药物。

公开(公告)号：US07199104B2

公开(公告)日：2007-04-03

申请号：US10797344

申请日：2004-03-10

Applicant: Bill H. McAnalley ,  H. Reginald McDaniel ,  D. Eric Moore ,  Eileen P. Vennum ,  William C. Fioretti

Inventor： Bill H. McAnalley ,  H. Reginald McDaniel ,  D. Eric Moore ,  Eileen P. Vennum ,  William C. Fioretti

IPC: A01N43/04 ,  A01N65/00 ,  A61K36/894

CPC classification number: A61K31/715 ,  A23L5/00 ,  A23L19/03 ,  A23L29/212 ,  A23L29/231 ,  A23L29/238 ,  A23L29/244 ,  A23L29/25 ,  A23L29/256 ,  A23L29/262 ,  A23L29/27 ,  A23L29/273 ,  A23L29/30 ,  A23L33/10 ,  A23L33/105 ,  A23L33/11 ,  A23L33/125 ,  A23V2002/00 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7012 ,  A23V2250/608 ,  A23V2250/61 ,  A23V2250/618 ,  A23V2250/638 ,  A23V2250/1578 ,  A23V2250/5056 ,  A23V2250/5084 ,  A23V2250/503 ,  A23V2250/506 ,  A23V2250/308 ,  A23V2250/5118 ,  A23V2250/2102 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2250/628

Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.

公开(公告)号：US20190091267A1

公开(公告)日：2019-03-28

申请号：US16198870

申请日：2018-11-22

Applicant: Shaanxi Jianhua Biopharmaceutical Co., Ltd.

Inventor： Jian HE ,  Hua WANG

IPC: A61K35/57 ,  A61K36/64 ,  A61K36/40 ,  A61K36/894 ,  A61K36/65 ,  A61K36/076 ,  A61K36/884 ,  A61K36/39 ,  A61K36/481 ,  A61K35/62 ,  A61K35/64 ,  A61K45/06 ,  A61K9/00 ,  A61P13/08

CPC classification number: A61K35/57 ,  A61K9/0014 ,  A61K35/12 ,  A61K35/586 ,  A61K35/618 ,  A61K35/62 ,  A61K35/63 ,  A61K35/64 ,  A61K36/076 ,  A61K36/39 ,  A61K36/40 ,  A61K36/481 ,  A61K36/64 ,  A61K36/65 ,  A61K36/884 ,  A61K36/894 ,  A61K36/8966 ,  A61K36/8969 ,  A61K36/902 ,  A61K36/904 ,  A61K36/9066 ,  A61K45/06 ,  A61P13/08 ,  A61P17/00 ,  A61K2300/00

Abstract: The invention provides a combined external medicine for treating prostate diseases and a method using the same. The combined external medicine includes a pre-immune composition comprising multi-immune powder and a noble bottle tree decoction, a lesion active composition comprising the multi-immune powder and a first medical decoction prepared from a first Chinese medical composition for treating prostate diseases, and a double rib active composition comprising the multi-immune powder and a second medical decoction prepared from a second Chinese medical composition for conditioning liver and kidney. The method includes applying the pre-immune composition on skin of lesion part and skin of the left and right ribs; waiting for 5-10 minutes; applying the lesion active composition and the double rib active composition on the skin of the lesion part and skin of the left and right ribs; and airing for 10-40 minutes.

公开(公告)号：US20190038695A1

公开(公告)日：2019-02-07

申请号：US15759052

申请日：2016-09-09

Applicant: Ming Jin

Inventor： Ming Jin

IPC: A61K36/481 ,  A61K36/36 ,  A61K36/54 ,  A61K36/232 ,  A61K36/258 ,  A61K36/894 ,  A61K36/537 ,  A61K36/64 ,  A61K36/28 ,  A61K35/62 ,  A61P27/02

CPC classification number: A61K36/481 ,  A61K35/62 ,  A61K36/232 ,  A61K36/258 ,  A61K36/28 ,  A61K36/284 ,  A61K36/36 ,  A61K36/537 ,  A61K36/54 ,  A61K36/64 ,  A61K36/804 ,  A61K36/894 ,  A61K36/8945 ,  A61P27/02 ,  A61K2300/00

Abstract: The present invention provides a traditional Chinese medicine (TCM) composition for the treatment of diabetic retinopathy, wherein the active pharmaceutical ingredients (APIs) of the said TCM composition are: Astragali Radix 10-80 parts by weight, Pseudostellariae Radix 5-30 parts by weight, Cinnamomi Ramulus 3-25 parts by weight, Angelicae Sinensis Radix 8-60 parts by weight, Notoginseng Radix ET Rhizoma 2-15 parts by weight, Dioscoreae Rhizoma 10-80 parts by weight, Salviae Miltiorrhizae Radix ET Rhizoma 10-80 parts by weight, Pheretima 2-15 parts by weight, Rehmanniae Radix 8-60 parts by weight, and Atractylodis Macrocephalae Rhizoma 8-60 parts by weight. It has been shown by clinical experiments that, the invented TCM composition has an exact efficacy in patients with macular edema and can effectively improve the patients' visual acuity and visual field and relieve ocular fundus diseases, playing an active role in alleviating macular edema.

公开(公告)号：US07645463B2

公开(公告)日：2010-01-12

申请号：US11582894

申请日：2006-10-18

Applicant: Rong-Tsun Wu

Inventor： Rong-Tsun Wu

IPC: A61K36/894

CPC classification number: A61K36/8945

Abstract: The present invention provides a method for treating diabetic vascular complications including administering to a subject in need thereof a therapeutically effective amount of an extract product of a Dioscorea species. The extract product preferably is prepared by a process which involves (a) extracting a tuber of the Dioscorea species with an alcohol-based solvent in the presence of an acetic acid solution to form an extract composition, (b) subjecting a resultant product obtained in step (a) to obtain a soluble fraction, and (c) removing solvent from the soluble fraction obtained in step (b) to obtain the extract product.

Abstract translation: 本发明提供了治疗糖尿病性血管并发症的方法，包括向有需要的受试者施用治疗有效量的薯a科植物提取物。 提取产物优选通过以下方法制备：（a）在乙酸溶液存在下，用醇类溶剂萃取薯a薯块茎以形成提取物组合物，（b）使得到的所得产物 步骤（a）获得可溶性级分，和（c）从步骤（b）中获得的可溶性级分中除去溶剂，得到提取物。

公开(公告)号：US07202220B2

公开(公告)日：2007-04-10

申请号：US10885545

申请日：2004-07-06

Applicant: Bill H. McAnalley ,  H. Reginald McDaniel ,  D. Eric Moore ,  Eileen P. Vennum ,  William C. Fioretti

Inventor： Bill H. McAnalley ,  H. Reginald McDaniel ,  D. Eric Moore ,  Eileen P. Vennum ,  William C. Fioretti

IPC: A01N43/04 ,  A01N65/00 ,  A61K36/894

CPC classification number: A61K31/715 ,  A23L5/00 ,  A23L19/03 ,  A23L29/212 ,  A23L29/231 ,  A23L29/238 ,  A23L29/244 ,  A23L29/25 ,  A23L29/256 ,  A23L29/262 ,  A23L29/27 ,  A23L29/273 ,  A23L29/30 ,  A23L33/10 ,  A23L33/105 ,  A23L33/11 ,  A23L33/125 ,  A23V2002/00 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7012 ,  A23V2250/608 ,  A23V2250/61 ,  A23V2250/618 ,  A23V2250/638 ,  A23V2250/1578 ,  A23V2250/5056 ,  A23V2250/5084 ,  A23V2250/503 ,  A23V2250/506 ,  A23V2250/308 ,  A23V2250/5118 ,  A23V2250/2102 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2250/628

Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.

Abstract translation: 植物碳水化合物用于膳食补充剂和营养支持的组合，用于促进和维持良好的健康。 定义的营养有效量的一至十一种必需糖，糖类营养素，用于各种本发明组合物中作为膳食补充剂。 本文的饮食组合物可以包括植物营养素，维生素，矿物质，草药提取物和其它无毒营养物质。 本发明的糖营养膳食补充剂提供作为糖蛋白的结构单元的必需糖。 已经发现这些组合物当口服或局部给药时，可以改善患有多种疾病的哺乳动物的健康。

公开(公告)号：US12194070B2

公开(公告)日：2025-01-14

申请号：US18621062

申请日：2024-03-28

Applicant: Ningxia Medical University ,  Ningxia Freedom Biological Pharmaceutical Technology Co., LTD

Inventor： Rui He ,  Guangyong Li ,  Xiaojiang Chen ,  Xiaoli Du ,  Xiangdong Zhu ,  Huiming Ma ,  Miao Sun ,  Jiafuruzi He

IPC: A61K36/00 ,  A61K36/076 ,  A61K36/185 ,  A61K36/232 ,  A61K36/235 ,  A61K36/236 ,  A61K36/24 ,  A61K36/284 ,  A61K36/344 ,  A61K36/48 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/62 ,  A61K36/67 ,  A61K36/714 ,  A61K36/754 ,  A61K36/894 ,  A61K36/9062 ,  A61K36/9068 ,  A61P15/08

Abstract: A traditional Chinese medicine compound for improving testicular dysfunction is made from the following raw materials: Codonopsis pilosula, Astragalus membranaceus, Dioscorea opposita, Angelica sinensis, Atractylodes macrocephala, Poria cocos, Cynanchum otophyllum, Psoralea corylifolia, Ligusticum chuanxiong, Nelumbo nucifera, Euryale ferox, Amomum villosum, Alpinia katsumadai, Foeniculum vulgare, Cinnamomum cassia, Evodia ruticarpa, Piper nigrum, Zingiber officinale, Aconitum carmichaelii, and Glycyrrhiza uralensis. All the raw materials are combined, so that the spleen, the stomach and the kidney are in harmony, the qi, the blood and the body fluid are recovered, and the kidney essence is active. Animal experiments show that the traditional Chinese medicine compound can up-regulate expressions of phosphatidylinositol 3-kinase (PI3K), phospho-protein kinase B (p-AKT) and B-cell lymphoma-2 (Bcl-2), improve testicular dysfunction, improve hormone secretion, regulate a male reproductive endocrine environment of the body, and further improve semen parameters.