公开(公告)号：US11992513B2

公开(公告)日：2024-05-28

申请号：US17953859

申请日：2022-09-27

Applicant: THE AFFILIATED HOSPITAL OF JIANGXI UNIVERSITY OF TCM

Inventor： Qi Dai ,  Kunshan Chen ,  Xiaoqi Zhou

IPC: A61K36/489 ,  A61K36/17 ,  A61K36/21 ,  A61K36/236 ,  A61K36/24 ,  A61K36/258 ,  A61K36/286 ,  A61K36/287 ,  A61K36/288 ,  A61K36/31 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/804 ,  A61K36/86 ,  A61K36/8884 ,  A61K36/90 ,  A61P17/00

CPC classification number: A61K36/489 ,  A61K36/17 ,  A61K36/21 ,  A61K36/236 ,  A61K36/24 ,  A61K36/258 ,  A61K36/286 ,  A61K36/287 ,  A61K36/288 ,  A61K36/31 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/804 ,  A61K36/86 ,  A61K36/8884 ,  A61K36/90 ,  A61P17/00

Abstract: A traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment is mainly prepared from the following components by weight: 20-50 parts of Radix Sophorae Flavescentis, 20-50 parts of Herba Taraxaci, 20-50 parts of Flos Chrysanthemi Indici, and 20-50 parts of Herba Cum Radice Violae Yedoensitis, 20-50 parts of Rhizoma Smilacis Glabrae, 30-60 parts of Radix Astragali Seu Hedysari, 10-35 parts of Kochia scoparia (L.) Schrad, 10-45 parts of Carthamus tinctorius L., 15-45 parts of Cortex Radicis Dictamni Dasycarpi, 5-15 parts of Herba Ephedrae, 5-25 parts of Angelica sinensis, 5-25 parts of Rhizoma Ligustici Chuangxiong, 10-30 parts of Radix Rehmanniae, 5-15 parts of Ramulus cinnamomi, 10-30 parts of Cynanchum otophyllum Schneid, 5-15 parts of Semen Sinapis Albae, 5-20 parts of Arisaema heterophyllum Blume, 5-20 parts of Typhonium blumei Nicolson & Sivadasan, and 10-40 parts of Radix Glycyrrhizae.

公开(公告)号：US11666619B2

公开(公告)日：2023-06-06

申请号：US16329562

申请日：2017-09-01

Applicant: University—Industry Cooperation Group of Kyung Hee University

Inventor： Seong-Gyu Ko ,  Inhwa Choi ,  Younghee Yun ,  Se Hyang Hong ,  Jin Mo Ku

IPC: A61K36/756 ,  A61P29/00 ,  A61K36/484 ,  A61K36/489 ,  A61K36/538 ,  A61K36/804 ,  A23L33/105 ,  A61K8/9789

CPC classification number: A61K36/756 ,  A61K36/484 ,  A61K36/489 ,  A61K36/538 ,  A61K36/804 ,  A61P29/00 ,  A23L33/105 ,  A61K8/9789 ,  A61K2236/333

Abstract: Provided are a composition for treating atopic dermatitis including an herbal medicine mixed extract, and more particularly, a pharmaceutical composition, a food composition, a quasi-drug composition, and a cosmetic composition for preventing or treating atopic dermatitis, each composition including a mixed extract of Phellodendri Cortex, Schizonepetae Spica, Sophorae Radix, Glycyrrhizae Radix, Liriopis Tuber, and Radix Rehmanniae Exsiccate or a fraction thereof, and a method of treating atopic dermatitis using the pharmaceutical composition.
The complex herbal medicine extract of the present invention may prevent, ameliorate, and treat atopic dermatitis to a degree similar or superior to those of the known therapeutic agents for atopic dermatitis.

公开(公告)号：US11207368B2

公开(公告)日：2021-12-28

申请号：US15235752

申请日：2016-08-12

Applicant: Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

Inventor： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC: A61K36/87 ,  A61K31/352 ,  A61K36/185 ,  A61K36/258 ,  A61K36/484 ,  A61K36/804 ,  A61K36/489 ,  A23L33/105 ,  A61K36/254

Abstract: Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

公开(公告)号：US10765647B2

公开(公告)日：2020-09-08

申请号：US15970282

申请日：2018-05-03

Applicant: COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

Inventor： Seok Bong Kang ,  Ho Sang Sohn ,  Joon Seok Byun ,  Ki Cheul Sohn ,  Sae Kwang Ku

IPC: A61K31/155 ,  A61K36/884 ,  A61K36/8945 ,  A61K36/40 ,  A61K36/65 ,  A61K36/804 ,  A61K36/076 ,  A61K36/53

Abstract: Provided is a composition for treating diabetes, including a hypoglycemic agent and a Yukmijihwang-tang extract. More particularly, the hypoglycemic agent is administered into an individual, and the Yukmijihwang-tang extract is administered into the individual, thereby considerably increasing a hypoglycemic effect of the hypoglycemic agent, and preventing and reducing various diabetic complications such as diabetes and diabetic liver damage, renal damage, hyperlipidemia immunosuppression and ocular damage.

公开(公告)号：US10286040B2

公开(公告)日：2019-05-14

申请号：US15854613

申请日：2017-12-26

Applicant: COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

Inventor： Chang Hyeong Lee ,  Sang Gyung Kim ,  Im Hee Shin ,  Seung Mo Kim ,  Joon Seok Byun ,  Ki Cheul Sohn ,  Sae Kwang Ku

IPC: A61K38/00 ,  A61K38/19 ,  C12N5/0789 ,  A61K36/804 ,  A61K36/076 ,  A61K36/232 ,  A61K36/234 ,  A61K36/258 ,  A61K36/284 ,  A61K36/484 ,  A61K36/65 ,  A61K36/07 ,  A61K36/64

Abstract: The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and more specifically, to a composition for promoting the proliferation of stem cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of G-CSF alone for proliferation and differentiation of the stem cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells.

公开(公告)号：US20170326191A1

公开(公告)日：2017-11-16

申请号：US15607655

申请日：2017-05-29

Applicant: Sirbal Ltd.

Inventor： Nadav Shraibom

IPC: A61K36/708 ,  A61K36/804 ,  A61K36/73 ,  A61K36/65 ,  A61K36/64 ,  A61K36/355 ,  A61K36/185 ,  A61K36/815 ,  A61K9/00

CPC classification number: A61K36/708 ,  A61K9/0019 ,  A61K36/185 ,  A61K36/355 ,  A61K36/64 ,  A61K36/65 ,  A61K36/73 ,  A61K36/804 ,  A61K36/815 ,  A61K2300/00

Abstract: A treatment regimen for psoriasis includes administering to a patient diagnosed with psoriasis periodic doses of a combination including Sheng Di Huang, Da Huang and Jin Yin Hua, or a combination of the above with Mu Dan Pi, Di Gu Pi, Xian He Cao and Chun Gen Pi.

公开(公告)号：US09662365B2

公开(公告)日：2017-05-30

申请号：US14946711

申请日：2015-11-19

Applicant: Sirbal, Ltd.

Inventor： Nadav Shraibom

IPC: A61K36/64 ,  A61K36/708 ,  A61K36/355 ,  A61K36/815 ,  A61K36/185 ,  A61K36/65 ,  A61K36/73 ,  A61K36/804 ,  A61K9/00

CPC classification number: A61K36/708 ,  A61K9/0019 ,  A61K36/185 ,  A61K36/355 ,  A61K36/64 ,  A61K36/65 ,  A61K36/73 ,  A61K36/804 ,  A61K36/815 ,  A61K2300/00

Abstract: A treatment regimen for psoriasis includes administering to a patient diagnosed with psoriasis periodic doses of a combination including Sheng Di Huang, Da Huang and Jin Yin Hua, or a combination of the above with Mu Dan Pi, Di Gu Pi, Xian He Cao and Chun Gen Pi.

公开(公告)号：US09511108B2

公开(公告)日：2016-12-06

申请号：US14491785

申请日：2014-09-19

Applicant: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

Inventor： Jinju Kim ,  Eunjung Ko ,  Eui Jeong Lee

IPC: A61K36/899 ,  A61K36/804 ,  A61K36/074

CPC classification number: A61K36/899 ,  A23L33/105 ,  A61K36/074 ,  A61K36/804

Abstract: The present invention relates to a method for treating chronic obstructive pulmonary disease (COPD) comprising the step of administering the extract of Phyllostachys nigra Munro var. henosis Stapf as an active ingredient. Particularly, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention can reduce the numbers of macrophages and neutrophils increased in bronchoalveolar lavage fluid (BALF) and is effective in preventing weight loss caused by chronic obstructive pulmonary disease and is effective in down-regulating significantly IL-6, TNF-α, IL-1β, MCP-1, and MMP-12, which are rapidly increased in bronchoalveolar lavage fluid, intrapulmonary tissue, and serum according to the development of chronic obstructive pulmonary disease. In addition, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention has the effect of blocking the activation of NF-κB signal in intrapulmonary tissue and significantly reduces inflammatory cells in the tissues around alveoli as well as significantly reduces the size of the enlarged alveola. Therefore, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention can be effectively used as an active ingredient of medicines and health food for the prevention and treatment of chronic obstructive pulmonary disease.

Abstract translation: 本发明涉及一种治疗慢性阻塞性肺病（COPD）的方法，包括以下步骤：施用黑曲霉木瓜提取物 会阴Stapf作为活性成分。 特别是黑叶木麻黄提取物 本发明的发音Stapf可以减少支气管肺泡灌洗液（BALF）中增加的巨噬细胞和嗜中性粒细胞的数量，有效预防慢性阻塞性肺疾病引起的体重减轻，有效下调IL-6，TNF-α ，IL-1β，MCP-1和MMP-12，根据慢性阻塞性肺疾病的发展，其在支气管肺泡灌洗液，肺内组织和血清中迅速增加。 此外，Phyllostachys nigra Munro var。 本发明的发音Stapf具有阻断肺内组织中NF-κB信号的活化并显着减少肺泡周围组织中的炎症细胞的作用，并且显着减小扩大的肺泡的大小。 因此，Phyllostachys nigra Munro var。 本发明的发音Stapf可以有效地用作预防和治疗慢性阻塞性肺疾病的药物和保健食品的活性成分。

公开(公告)号：US09327004B2

公开(公告)日：2016-05-03

申请号：US14043021

申请日：2013-10-01

Applicant: Jing Cheng ,  Chia-wen Chen ,  Steven Francis Schnittger ,  Ming Lu

Inventor： Jing Cheng ,  Chia-wen Chen ,  Steven Francis Schnittger ,  Ming Lu

IPC: A61K36/725 ,  A61K8/97 ,  A61K8/99 ,  A61Q19/00 ,  A61K36/752 ,  A61K36/756 ,  A61K36/804 ,  A61K36/8998 ,  A61K36/068 ,  A61K36/074 ,  A61K36/076 ,  A61K36/10 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/235 ,  A61K36/236 ,  A61K36/258 ,  A61K36/28 ,  A61K36/41 ,  A61K36/535 ,  A61K36/539 ,  A61K36/65 ,  A61K36/704 ,  A61K36/06 ,  A61K36/69

CPC classification number: A61K36/725 ,  A61K8/97 ,  A61K8/99 ,  A61K36/06 ,  A61K36/068 ,  A61K36/074 ,  A61K36/076 ,  A61K36/10 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/235 ,  A61K36/236 ,  A61K36/258 ,  A61K36/28 ,  A61K36/41 ,  A61K36/535 ,  A61K36/539 ,  A61K36/65 ,  A61K36/69 ,  A61K36/704 ,  A61K36/752 ,  A61K36/756 ,  A61K36/804 ,  A61K36/8998 ,  A61K2800/85 ,  A61Q19/00

Abstract: The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.

公开(公告)号：US08449929B2

公开(公告)日：2013-05-28

申请号：US13613654

申请日：2012-09-13

Applicant: Chen-Yu Lee ,  Jiang Jung Chen

Inventor： Chen-Yu Lee ,  Jiang Jung Chen

IPC: A61K36/00 ,  A61K36/236 ,  A61K36/539 ,  A61K36/232 ,  A61K36/744 ,  A61K36/804 ,  A61K36/515 ,  A61K36/233 ,  A61K36/284

CPC classification number: A61K36/71 ,  A61K33/04 ,  A61K36/185 ,  A61K36/232 ,  A61K36/236 ,  A61K36/28 ,  A61K36/284 ,  A61K36/46 ,  A61K36/484 ,  A61K36/515 ,  A61K36/539 ,  A61K36/54 ,  A61K36/64 ,  A61K36/65 ,  A61K36/725 ,  A61K36/804 ,  A61K36/815 ,  A61K36/8945 ,  A61K36/9068 ,  A61K2300/00

Abstract: The present invention relates to herbal medicinal compositions and extracts thereof for inhibiting growth of cancer cells. One of the examples described in the present invention comprises Forsythiae fructus, Menthae Herba, Gardeniae Fructus, Scutellariae Radix, Lophatheri Folium, Glycyrrhizae Radix, Rhei Rhizoma, Na2SO4, and Atractylodis Rhizoma. The residual examples are described herein.