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公开(公告)号：US11747325B2
公开(公告)日：2023-09-05
申请号：US15734327
申请日：2019-06-07
Applicant: Novagray
Inventor： Adeline Torro , Clémence Franc
CPC classification number: G01N33/5005 , G01N33/6893 , G01N2800/40 , G01N2800/56 , G01N2800/7004
Abstract: The present invention relates to a method for mimicking the effects of ionizing radiations on cells, wherein cells are contacted with bleomycin.
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公开(公告)号：US09874573B2
公开(公告)日：2018-01-23
申请号：US15188822
申请日：2016-06-21
Applicant: GAIA Medical Institute
Inventor： Sarka O. Southern
CPC classification number: G01N33/6893 , A61B10/00 , A61B10/0045 , A61B10/0051 , A61B10/007 , A61B10/025 , A61B2010/0067 , A61B2010/0074 , A61B2010/0087 , A61B2010/0258 , G01N2030/8813 , G01N2800/7004
Abstract: Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.
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公开(公告)号：US20170227527A1
公开(公告)日：2017-08-10
申请号：US15355227
申请日：2016-11-18
Applicant: HemoShear, LLC
Inventor： Brett R. Blackman , Brian R. Wamhoff , Ajit Dash , Michael B. Simmers , Ryan E. Feaver
IPC: G01N33/50
CPC classification number: G01N33/5067 , C12M35/04 , G01N33/5008 , G01N33/5023 , G01N33/5091 , G01N2500/10 , G01N2800/7004
Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
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4.发明申请公开(公告)号：US20170219585A1
公开(公告)日：2017-08-03
申请号：US15485420
申请日：2017-04-12
Inventor： Larisa Geskin , Oleg E. Akilov
IPC: G01N33/574 , G01N33/50
CPC classification number: G01N33/57407 , A61K38/212 , G01N33/5011 , G01N33/84 , G01N2333/4706 , G01N2333/90 , G01N2333/978 , G01N2800/52 , G01N2800/7004
Abstract: The present invention relates to methods and materials for more effectively treating patients with interferon. It is based on the discovery that clinical response to interferon (IFN) therapy is mediated in part by inhibition of activation of MDSC and such inhibition can be observed after a test dose of interferon; a significant decrease of reactive oxygen species (ROS) production by MDSC (as a measure of their activation) after IFN therapy is predictive of overall response to immunotherapy in cancer patients.
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公开(公告)号：US09638703B2
公开(公告)日：2017-05-02
申请号：US15105550
申请日：2014-12-17
Inventor： Johan Aerts , Sarah De Saeger
CPC classification number: G01N33/743 , G01N33/68 , G01N33/74 , G01N2333/4603 , G01N2800/7004
Abstract: This disclosure relates to determining the stress level experienced by fish over a long period of time, which can be used in assessing the welfare status of fish. More, in particular, this disclosure relates to the usage of scales as well as other calcified tissue such as otoliths, spines and soft fin ray sampled from fish to quantify glucocorticoid levels in the scales/matrix. The levels of the glucocorticoids, such as cortisol or corticosterone, build up over time in scales and reflect long-lasting and stressful conditions that the fish have undergone during their lives and that have affected their level of stress. Hence, in vitro methods are disclosed herein that quantify the level of chronic stress in fish using scales as a logistic feasible, and non-invasive matrix for accurate and precise quantification of stress hormones.
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Patent Agency Ranking
公开(公告)号：US20140378332A1
公开(公告)日：2014-12-25
申请号：US14325252
申请日：2014-07-07
Applicant: Sarka O. Southern
Inventor： Sarka O. Southern
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N33/528 , G01N2800/30 , G01N2800/60 , G01N2800/7004
Abstract: Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.
Abstract translation: 本文提供了通过检测应激反应途径生物标志物的改变水平来检测病症或病症的方法和装置。 还提供了用于鉴定与病症或病症相关的生物标志物组的方法和试剂。
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7.发明申请METHODS OF DIAGNOSIS AND TREATMENT OF ENDOPLASMIC RETICULUM (ER) STRESS-RELATED CONDITIONS 审中-公开诊断和治疗内皮细胞（ER）应力相关条件的方法公开(公告)号：US20140348857A1
公开(公告)日：2014-11-27
申请号：US14353940
申请日：2012-10-26
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Paul Chang , Miri Jwa , Sejal Kamlesh Vyas
IPC: G01N33/573 , C07K16/40 , C12N15/113
CPC classification number: G01N33/573 , A61K31/7105 , C07K16/40 , C12N15/1137 , C12Q1/48 , G01N2333/91142 , G01N2500/04 , G01N2800/7004
Abstract: The present invention relates to methods for treating endoplasmic reticulum (ER) stress-related conditions (e.g., cancer, protein folding/misfolding disease, diabetes mellitus) and for identifying compounds for treating ER stress-related conditions in a subject (e.g., a human). The invention also provides methods for diagnosing an ER stress-related condition in a subject and kits for the treatment of same.
Abstract translation: 本发明涉及用于治疗内质网（ER）应激相关病症（例如癌症，蛋白质折叠/错误折叠疾病，糖尿病）的治疗方法，以及用于鉴定用于治疗受试者的ER应激相关病症的化合物（例如，人 ）。 本发明还提供了用于诊断受试者的ER应激相关病症的方法和用于治疗其的试剂盒。
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公开(公告)号：US20120201747A1
公开(公告)日：2012-08-09
申请号：US13364651
申请日：2012-02-02
Applicant: Randice Lisa Altschul , Neil David Theise , Myron Rapkin , Rebecca O'Brien
Inventor： Randice Lisa Altschul , Neil David Theise , Myron Rapkin , Rebecca O'Brien
IPC: A61K31/58 , A61K51/00 , A61K31/7068 , A61K33/24 , A61K31/665 , A61K31/7076 , A61K38/12 , A61K31/704 , A61K38/50 , A61P25/24 , A61P25/18 , A61P5/00 , A61P35/02 , C07J17/00 , G01N33/566 , G01N33/53 , C40B30/04 , A61N5/00 , A61J1/05 , A61P35/00 , B82Y5/00
CPC classification number: A61K31/58 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/107 , A61K31/00 , A61K31/337 , A61K45/06 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/42 , A61K47/44 , A61N5/1001 , B65D75/367 , C07J17/00 , G01N33/743 , G01N2800/04 , G01N2800/304 , G01N2800/52 , G01N2800/7004 , A61K2300/00
Abstract: This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.
Abstract translation: 本发明涉及一种低成本快速反应诊断系统，用于确定选择为使用GCR拮抗剂（例如ORG 34517）的GCR（糖皮质激素受体）拮抗剂治疗的潜在候选者的皮质醇水平。可以使用快速，灵敏和廉价的测试 确定具有非正常皮质醇生产或无序昼夜节律的患者作为选择可能具有有益和/或治疗作用的GCR拮抗剂治疗对象的方法，并且也可用于监测皮质醇水平的变化 对治疗的反应。
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公开(公告)号：US20230417771A1
公开(公告)日：2023-12-28
申请号：US18367986
申请日：2023-09-13
Applicant: GAIA MEDICAL INSTITUTE
Inventor： Sarka O. Southern
CPC classification number: G01N33/6893 , A61B10/00 , A61B10/0045 , A61B10/0051 , A61B10/007 , A61B10/025 , G01N2800/7004 , A61B2010/0067 , A61B2010/0074 , A61B2010/0087 , A61B2010/0258 , G01N2030/8813
Abstract: Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biontarkers associated with condition or disorder.
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公开(公告)号：US20180045714A1
公开(公告)日：2018-02-15
申请号：US15599821
申请日：2017-05-19
Applicant: HemoShear, LLC
Inventor： Brett R. Blackman , Brian R. Wamhoff , Ajit Dash , Michael B. Simmers , Ryan E. Feaver
CPC classification number: G01N33/5067 , C12M35/04 , G01N33/5008 , G01N33/5023 , G01N33/5091 , G01N2500/10 , G01N2800/7004
Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
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