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1.发明申请公开(公告)号：US20140120125A1
公开(公告)日：2014-05-01
申请号：US14126504
申请日：2012-06-18
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , A61K2039/55583 , A61K2039/70 , C12N2770/24134 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , G01N2333/185 , G01N2469/20 , G01N2800/26 , Y02A50/383 , Y02A50/39
摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Particles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti.
摘要翻译： 公开了用于预防和治疗基孔肯雅病毒感染的疫苗组合物，其能够赋予对基孔肯雅病毒的任何基因型变体的免疫力。 更具体地，本发明公开了特定的核苷酸序列及其翻译的蛋白质，其可以表达为病毒样颗粒，其用作针对基孔肯雅病毒感染的疫苗抗原。 本发明公开的组合物还可以防止任何基因昆亚病毒的基因型变体，其可以通过任何合适的疾病载体繁殖，包括白纹伊蚊（Aedis albopictus）和埃及伊蚊（Aedis aegypti）。
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公开(公告)号：US09402890B2
公开(公告)日：2016-08-02
申请号：US13983279
申请日：2012-02-01
申请人： Ilya Frolov , Elena Frolova
发明人： Ilya Frolov , Elena Frolova
CPC分类号： A61K39/12 , A61K35/76 , C07K14/005 , C07K14/1808 , C12N7/00 , C12N2770/36111 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , Y02A50/382
摘要： The present invention provides pseudoinfectious alphavirus particles and methods of making them and using them to produce an immune response to an alphavirus in a subject.
摘要翻译： 本发明提供假感染性甲病毒颗粒及其制备方法，并使用它们产生受试者中甲病毒的免疫应答。
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3.发明申请NOVEL ISOLATED AND PURIFIED STRAINS OF CHIKUNGUNYA VIRUS AND POLYNUCLEOTIDES AND POLYPEPTIDES SEQUENCES, DIAGNOSTIC AND IMMUNOGENICAL USES THEREOF 有权CH UN A A US OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF公开(公告)号：US20150111197A1
公开(公告)日：2015-04-23
申请号：US14335065
申请日：2014-07-18
IPC分类号： G01N33/569 , C07K14/005 , C12N7/00 , C07K16/10
CPC分类号： G01N33/56983 , A61K38/00 , A61K39/00 , C07K14/005 , C07K16/1081 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , C12N2770/36131 , G01N2333/181 , G01N2800/32 , Y02A50/383 , Y02A50/51
摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
摘要翻译： 本发明涉及从表现出严重感染形式的患者和从人类阿博病病毒流行中产生的患者分离的基孔肯雅病毒的野生菌株。 本发明还涉及衍生自其基因组的多肽序列及其片段，编码它们的多核苷酸及其作为诊断产品的用途，作为疫苗和/或免疫原性组合物。
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公开(公告)号：US20230365622A1
公开(公告)日：2023-11-16
申请号：US17638108
申请日：2020-08-27
发明人： David William PROVANCE, Jr. , Andressa da Matta DURANS , Paloma Napleão PÊGO , Salvatore Giovanni DE SIMONE
IPC分类号： C07K1/04 , G01N33/569
CPC分类号： C07K1/042 , G01N33/569 , G01N2333/44 , G01N2333/175 , G01N2333/181 , G01N2333/165
摘要： The present invention relates to a protein receptacle capable of receiving several exogenous polyamino acid sequences, concomitantly, for expression in various systems and for different uses. The present invention relates to polynucleotides capable of generating the aforementioned protein receptacle. The present invention also relates to vector and expression cassette comprising the aforementioned polynucleotide. The present invention further relates to the cell comprising the aforementioned expression vector or cassette. The present invention further relates to a method for producing said protein receptacle and for pathogen identification or disease diagnosis in vitro. The present invention further relates to the use of said protein receptacle and kit comprising said protein receptacle for diagnostic purposes or as vaccine compositions.
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5.发明授权Isolated and purified strains of Chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof 有权分离和纯化的基孔肯雅病毒菌株和多核苷酸和多肽序列，其诊断和免疫原用途公开(公告)号：US09442114B2
公开(公告)日：2016-09-13
申请号：US14335065
申请日：2014-07-18
申请人： INSTITUT PASTEUR
IPC分类号： G01N33/569 , C07K14/005 , C12N7/00 , C07K16/10 , A61K38/00 , A61K39/00
CPC分类号： G01N33/56983 , A61K38/00 , A61K39/00 , C07K14/005 , C07K16/1081 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , C12N2770/36131 , G01N2333/181 , G01N2800/32 , Y02A50/383 , Y02A50/51
摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
摘要翻译： 本发明涉及从表现出严重感染形式的患者和从人类阿博病病毒流行中产生的患者分离的基孔肯雅病毒的野生菌株。 本发明还涉及衍生自其基因组的多肽序列及其片段，编码它们的多核苷酸及其作为诊断产品的用途，作为疫苗和/或免疫原性组合物。
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公开(公告)号：US20140065178A1
公开(公告)日：2014-03-06
申请号：US13983279
申请日：2012-02-01
申请人： Ilya Frolov , Elena Frolova
发明人： Ilya Frolov , Elena Frolova
CPC分类号： A61K39/12 , A61K35/76 , C07K14/005 , C07K14/1808 , C12N7/00 , C12N2770/36111 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , Y02A50/382
摘要： The present invention provides pseudoinfectious alphavirus particles and methods of making them and using them to produce an immune response to an alphavirus in a subject.
摘要翻译： 本发明提供假感染性甲病毒颗粒及其制备方法，并使用它们产生受试者中甲病毒的免疫应答。
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7.发明授权公开(公告)号：US12050216B2
公开(公告)日：2024-07-30
申请号：US17690115
申请日：2022-03-09
发明人： Tzong-Yuan Wu , Szu-Cheng Kuo , Pei-Yun Shu , Chang-Chi Lin , Der-Jiang Chiao , Ying-Ju Chen , Yi-Ting Lin , Shu-Fen Chang , Chien-Ling Su
IPC分类号： G01N33/569 , C07K14/005 , C12N7/00 , G01N33/68 , C07K14/05
CPC分类号： G01N33/56983 , C07K14/005 , C12N7/00 , G01N33/6854 , C07K14/05 , C12N2710/14031 , C12N2710/14043 , C12N2770/24121 , C12N2770/24122 , C12N2770/24221 , C12N2770/36121 , C12N2770/36221 , C12N2810/609 , G01N2333/18 , G01N2333/181 , G01N2333/185 , G01N2333/186 , G01N2333/19
摘要： Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.
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公开(公告)号：US20170298346A9
公开(公告)日：2017-10-19
申请号：US14757293
申请日：2014-06-16
IPC分类号： C12N15/11 , G01N33/569
CPC分类号： C12N15/11 , C12N15/1131 , C12N2310/127 , C12N2310/351 , C12N2310/3517 , C12N2320/10 , C12N2770/24122 , C12Q1/6816 , C12Q1/701 , G01N33/5308 , G01N33/56983 , G01N33/588 , G01N2333/181 , G01N2333/185 , Y02A50/51 , Y02A50/53 , Y02A50/60 , C12Q2521/345 , C12Q2565/113
摘要： The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic acids. One aspect of the invention relates to compounds comprising DNAzymes conjugated to nanoparticles (DZ-NP), such as metallic or gold nanoparticles, and methods for their synthesis. Another aspect of the invention relates to methods of using the conjugated compounds to detect nucleic acids, such as genomic material or transcripts of infectious agents, such as viruses, exemplified by applications demonstrating visual detection of Flavivirus RNA molecules, such as dengue virus, or Alphavirus RNA molecules, such as chikungunya virus, in short time periods, using compositions comprising stable components.
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公开(公告)号：US09422529B2
公开(公告)日：2016-08-23
申请号：US14525820
申请日：2014-10-28
申请人： Farooq Nasar , Jesse Erasmus , Scott C. Weaver
发明人： Farooq Nasar , Jesse Erasmus , Scott C. Weaver
IPC分类号： C12N7/00 , G01N33/569 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , C12N2770/36121 , C12N2770/36134 , G01N33/56983 , G01N2333/181 , G01N2469/20
摘要： Embodiments are directed compositions related to Eilat virus and uses thereof. Certain aspects are directed to the detection of non-Eilat entities using a chimeric Eilat alphavirus as a capture agent.
摘要翻译： 实施方案涉及与埃拉特病毒有关的组合物及其用途。 某些方面涉及使用嵌合的埃拉特甲病毒作为捕获剂检测非埃拉特实体。
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公开(公告)号：US09844588B2
公开(公告)日：2017-12-19
申请号：US14126504
申请日：2012-06-18
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , A61K2039/55583 , A61K2039/70 , C12N2770/24134 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , G01N2333/185 , G01N2469/20 , G01N2800/26 , Y02A50/383 , Y02A50/39
摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Particles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti.
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