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    Automated system and method for simultaneously performing a plurality of signal-based assays
    2.
    发明授权
    Automated system and method for simultaneously performing a plurality of signal-based assays 失效
    用于同时执行多个基于信号的测定的自动系统和方法

    公开(公告)号：US07427380B2

    公开(公告)日：2008-09-23

    申请号：US10836425

    申请日：2004-05-03

    申请人： John A. McNeil ,  Michael Anthony Akong ,  Donald James Mierzeski ,  Gonul Velicelebi ,  David Philip Karlton

    发明人： John A. McNeil ,  Michael Anthony Akong ,  Donald James Mierzeski ,  Gonul Velicelebi ,  David Philip Karlton

    IPC分类号： B01L3/00

    CPC分类号： G01N35/0099 ,  B01J2219/00315 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00702 ,  C40B60/14 ,  G01N33/5302 ,  G01N33/5304 ,  G01N35/0092 ,  G01N35/028 ,  G01N35/1065 ,  G01N2035/00752 ,  G01N2035/0093 ,  Y10T436/115831

    摘要： An automated detection system includes a robotic fluid handling system for performing a plurality of assays; a detection system for imaging the assays as they are performed; and a computer control, data acquisition, and data analysis system for controlling the operation of the fluid-handling and detection system and for collecting and analyzing imaging data. The automated detection system comprises a pipettor for simultaneously distributing a predetermined amount of a liquid and a signal-generating element to each of the plurality of wells; an excitation source for simultaneously exposing the wells to excitation radiation; a detector for simultaneously detecting signal emitted from each of the wells over a period of time comprising a single imager for optically imaging the plurality of wells simultaneously; and computerized controller for simultaneously coordinating the pipettor, the excitation source, and the detector. Further, a method for performing simultaneous assays includes the steps of simultaneously distributing a predetermined amount of a liquid solution to each of a plurality of samples, simultaneously exposing the wells to excitation radiation, simultaneously detecting signals emitted from the wells using a detector comprising a single imaging means, and simultaneously controlling and coordinating the distribution, excitation, and detection using a computerized controller.

    摘要翻译： 一种自动化检测系统，包括用于执行多个测定的机器人流体处理系统; 用于在进行测定时对分析进行成像的检测系统; 以及用于控制流体处理和检测系统的操作并用于收集和分析成像数据的计算机控制，数据采集和数据分析系统。 该自动检测系统包括移液器，用于同时将预定量的液体和信号产生元件分配到多个孔中的每一个; 用于同时将阱暴露于激发辐射的激发源; 检测器，用于同时检测在一段时间内从每个孔发射的信号，包括单个成像器，用于同时对多个孔进行光学成像; 和计算机控制器，用于同时协调移液器，激发源和检测器。 此外，用于执行同时测定的方法包括以下步骤：将预定量的液体溶液分配到多个样品中的每一个，同时将孔暴露于激发辐射，同时使用检测器检测从孔发射的信号，所述检测器包括单个 成像装置，并且使用计算机控制器同时控制和协调分布，激励和检测。

    Distributed database for analytical instruments
    3.
    发明授权
    Distributed database for analytical instruments 有权
    分析仪器分布式数据库

    公开(公告)号：US07343248B2

    公开(公告)日：2008-03-11

    申请号：US11069632

    申请日：2005-02-28

    申请人： J. Wallace Parce ,  Morten J. Jensen

    发明人： J. Wallace Parce ,  Morten J. Jensen

    IPC分类号： G01N33/48

    CPC分类号： B01L3/5027 ,  B01L2200/143 ,  G01N35/0092 ,  G01N2035/0093 ,  Y10T436/115831 ,  Y10T436/25375 ,  Y10T436/2575

    摘要： Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequentially run past down a main channel to a detection zone of the microfluidic device in order to analyze the fluids. In order to increase the efficiency of the analysis, fluids can be processed in parallel by running one fluid down the main channel while another fluid is loaded to the main channel.

    摘要翻译： 提供了控制分析仪器的技术。 可以使用一系列步骤来指定微流体装置的孔，将要施加到井中的流体的移动性以及施加移动性的持续时间。 例如，为了分析流体，流体可以顺序地沿主通道向下流动到微流体装置的检测区域。 为了提高分析效率，可以通过在主通道下方运行一个流体同时将另一个流体加载到主通道来并行处理流体。

    Automatic analyzer
    4.
    发明申请
    Automatic analyzer 审中-公开
    自动分析仪

    公开(公告)号：US20050112025A1

    公开(公告)日：2005-05-26

    申请号：US10994286

    申请日：2004-11-23

    申请人： Katsuaki Takahashi ,  Masaharu Nishida

    发明人： Katsuaki Takahashi ,  Masaharu Nishida

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N35/025 ,  G01N35/00603 ,  G01N35/0092 ,  G01N35/1011 ,  G01N2035/0093

    摘要： An automatic analyzer which can perform automatic re-measurement, can release a sample for transfer to another unit, can easily perform pre-dilution of the sample, and is adaptable for a reduction in amount of the sample. The automatic analyzer comprises a reaction disk holding a plurality of reaction cells arranged in a row along the circumference of the reaction disk, and a sample dispensing mechanism for dispensing samples into the reaction cells on the reaction disk. The sample dispensing mechanism comprises a dispensing nozzle for dispensing the samples and a support mechanism for supporting the dispensing nozzle, and the support mechanism is disposed inside the circumference of the reaction disk along which the reaction cells are arranged in a row.

    摘要翻译： 可以进行自动重新测量的自动分析仪可以释放样品以转移到另一个单元，可以容易地进行样品的预稀释，并且适用于减少样品量。 所述自动分析装置包括：反应盘，其保持沿所述反应盘的圆周排成一行的多个反应池;以及样品分配机构，用于将样品分配到所述反应盘上的反应池中。 样品分配机构包括用于分配样品的分配喷嘴和用于支撑分配喷嘴的支撑机构，并且支撑机构设置在反应盘的圆周内，反应室沿着该圆周排成一行。

    Method for the management of workcell systems based on an automation management system
    6.
    发明授权
    Method for the management of workcell systems based on an automation management system 有权
    基于自动化管理系统管理工作单元系统的方法

    公开(公告)号：US06721615B2

    公开(公告)日：2004-04-13

    申请号：US10113575

    申请日：2002-04-02

    申请人： Daniele Fava ,  Elisabetta Garghentino ,  Gianandrea Pedrazzini

    发明人： Daniele Fava ,  Elisabetta Garghentino ,  Gianandrea Pedrazzini

    IPC分类号： G06F1904

    CPC分类号： G01N35/00603 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/021 ,  G01N2035/0093 ,  G05B19/0426 ,  G05B19/41865 ,  G05B2219/32247 ,  G05B2219/32287 ,  G05B2219/32298 ,  G05B2219/32328 ,  Y02P90/20 ,  Y02P90/265

    摘要： A method for the management of a Workcell System capable to control concurrent processes that use pieces of equipment, here called Resources, interacting with each other according to the needs and the changes that have not been forecast in advance in their process cycles, by means of a continuous real-time re-scheduling of automatic tasks. According to an embodiment, the method for the management of Workcell Systems, using an Automation Management System to control a plurality of Resources, designated to handle Samples along the Workcell Systems to perform operations on the Samples, includes associating a Sample Protocol to each Sample, associating to each Resource a Resource Driver, controlling the Resource Drivers by a Process Controller which communicates with the Resource Drivers by means of variables associated to each Resource, executing the Sample Protocols by the Process Controller in a concurrent way, and automatically modifying the Sample Protocols by continuously re-scheduling automatic tasks on different Resources, according to the results of the execution of the Sample Protocols and the status of the Resources, as indicated by the status of the variables, and thus obtaining an intelligent and reactive control of the workflow, automatically and dynamically taking the appropriate decisions.

    摘要翻译： 一种用于管理工作单元系统的方法，该系统能够根据需要以及在其工艺周期中未预先预测的变化来控制使用这些称为资源的设备的并行过程，这些设备相互交互，通过 连续实时重新调度自动任务。 根据实施例，用于管理Workcell系统的方法，使用自动化管理系统来控制指定用于处理沿着工作单元系统的样本以执行对样本的操作的多个资源，包括将样本协议关联到每个样本， 将每个资源与资源驱动程序相关联，通过与每个资源相关联的变量与资源驱动程序进行通信的过程控制器控制资源驱动程序，并行方式由过程控制器执行示例协议，并自动修改示例协议 通过根据变量的状态指示的样本协议的执行结果和资源的状态不断重新调度不同资源上的自动任务，从而获得工作流的智能和反应性控制， 自动和动态地作出适当的决定。

    Automated laboratory software architecture
    9.
    发明授权
    Automated laboratory software architecture 有权
    自动实验室软件架构

    公开(公告)号：US06581012B1

    公开(公告)日：2003-06-17

    申请号：US09364602

    申请日：1999-07-30

    申请人： Michael Aryev ,  Andrea L. Krensky ,  Fredric W. Huls ,  Gerardo Garcia ,  Bin Qin ,  David J. Roach

    发明人： Michael Aryev ,  Andrea L. Krensky ,  Fredric W. Huls ,  Gerardo Garcia ,  Bin Qin ,  David J. Roach

    IPC分类号： G06F1900

    CPC分类号： G01N35/0092 ,  G01N2035/0093 ,  G05B19/41865 ,  G06F19/00 ,  G06Q50/22 ,  G16H10/40 ,  Y02P90/20

    摘要： An integrated clinical laboratory software system for testing a specimen. At least one specimen processing module is advantageously provided, each for performing particular predetermined tests on the specimen. Integrated work flow automation programming communicates with any of the plurality of specimen processing modules. The specimen processing modules can include instrument hardware and embedded process control software. The work flow automation programming includes request processing programming for processing a user request for any of the tests which are available to be performed by the specimen processing modules, and also includes functional control programming which provides functional control of any of the plurality of specimen processing modules for performing any of the tests, and which further includes result data management programming provides processing of test result data of any of the tests.

    摘要翻译： 一个用于测试样本的综合临床实验室软件系统。 有利地提供至少一个样本处理模块，每个用于对样本执行特定的预定测试。 集成工作流程自动化程序与多个样本处理模块中的任何一个进行通信。 样品处理模块可以包括仪器硬件和嵌入式过程控制软件。 工作流程自动化编程包括用于处理用户对由样本处理模块可执行的任何测试的请求的请求处理程序，并且还包括提供对多个样本处理模块中的任何一个进行功能控制的功能控制程序 用于执行任何测试，并且还包括结果数据管理编程提供对任何测试的测试结果数据的处理。