公开(公告)号：US11965181B2

公开(公告)日：2024-04-23

申请号：US17351381

申请日：2021-06-18

申请人： RIVER STONE BIOTECH LLC

发明人： Esben Halkjaer Hansen ,  Markus Schwab ,  Philipp Berninger ,  Fanny Delgrange ,  Franziska Grassinger

IPC分类号： C12N9/04 ,  C12N9/02 ,  C12P17/12

CPC分类号： C12N9/0006 ,  C12N9/0008 ,  C12P17/12 ,  C12Y101/01001 ,  C12Y101/01006 ,  C12Y101/01021 ,  C12Y101/01026 ,  C12Y101/01034 ,  C12Y101/01035 ,  C12Y101/01041 ,  C12Y101/01046 ,  C12Y101/01049 ,  C12Y101/01076 ,  C12Y101/0109 ,  C12Y101/05003

摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.

公开(公告)号：US20170137855A1

公开(公告)日：2017-05-18

申请号：US15353188

申请日：2016-11-16

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Kechun Zhang ,  Yi-shu Tai ,  Pooja Jambunathan

IPC分类号： C12P19/02 ,  C12P7/40 ,  C12N9/88 ,  C12N9/04 ,  C12N9/18

CPC分类号： C12Y402/01025 ,  C12N9/0006 ,  C12N9/18 ,  C12N9/88 ,  C12P7/18 ,  C12P7/40 ,  C12P7/44 ,  C12Y101/01046 ,  C12Y301/01015 ,  C12Y402/01043

摘要： This disclosure describes methods for screening heterologous coding regions (e.g., a single gene coding region, and operon, or other gene cluster) for the ability to genetically modify a host cell to perform nonphosphorylative biosynthesis of 2,5-dioxopentanoate and downstream derivatives thereof (e.g., 1,4-butanediol, glutamate, or glutaconate. This disclosure further describes recombinant cells modified to increase nonphosphorylative biosynthesis of 2,5-dioxopentanoate compared to an appropriate control cell (e.g., a wild-type cell or an otherwise genetically-modified cell) and methods of using making and using such recombinant cells.

公开(公告)号：US20150291988A1

公开(公告)日：2015-10-15

申请号：US14440022

申请日：2013-11-08

申请人： ANNIKKI GMBH

发明人： Dörthe Hendrike Wirtz ,  Bernd Mayer

IPC分类号： C12P19/02 ,  C12P7/50 ,  C12P7/42

CPC分类号： C12P19/02 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/50 ,  C12P2201/00 ,  C12P2203/00 ,  C12Y101/01046 ,  C13K13/00 ,  C13K13/002

摘要： A process for converting a sugar from a hemicellulose-containing material into the form of a compound having at least one ionic binding site, which is characterized in that the hemicellulose-containing material is hydrolyzed enzymatically or non-enzymatically and the obtained hydrolysate is subjected to a conversion involving at least one enzymatic step, wherein sugars are released and the released sugars are converted into compounds having at least one ionic binding site, and the use of such a process.

摘要翻译： 将糖从含半纤维素材料转化为具有至少一个离子结合位点的化合物的形式的方法，其特征在于含有半纤维素的材料在酶促或非酶水解的条件下进行，并将所得水解产物 涉及至少一个酶促步骤的转化，其中糖被释放并且释放的糖被转化为具有至少一个离子结合位点的化合物，以及使用这种方法。