Patent search cpc:"C12N2770/00033" Page 1

1.

发明申请
RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci 审中-公开
Title translation: 基因和表观基因调控蛋白的RNA引导靶向特异性基因组位点

公开(公告)号：US20160010076A1

公开(公告)日：2016-01-14

申请号：US14775869

申请日：2014-03-14

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： J. Keith Joung , Morgan Maeder

IPC: C12N9/96 , C07K14/195 , C12N9/16 , C07K14/005 , C12N9/10 , C12N9/02

CPC classification number: C12N15/907 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004

Abstract: Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci.

Abstract translation: 用于RNA引导靶向异源功能结构域（如转录激活子）到特定基因组基因座的方法和构建体。

2.

发明公开
Increasing Specificity for RNA-Guided Genome Editing 审中-公开

公开(公告)号：US20240240207A1

公开(公告)日：2024-07-18

申请号：US18415999

申请日：2024-01-18

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung , James Angstman , Shengdar Tsai

IPC: C12N15/90 , C07K14/005 , C07K14/195 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/10 , C12N15/11 , C12N15/63 , C12N15/85

CPC classification number: C12N15/907 , C07K14/005 , C07K14/195 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12Y301/21004 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

3.

发明申请
Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing 审中-公开

公开(公告)号：US20170327805A1

公开(公告)日：2017-11-16

申请号：US15415431

申请日：2017-01-25

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung , Shengdar Tsai

IPC: C12N9/22 , C12N15/10 , C12N15/11 , C12N2310/20

CPC classification number: C12N15/102 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

4.

发明授权
Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing 有权
Title translation: 使用截短的引导RNA（tru-gRNA）增加RNA指导基因组编辑的特异性

公开(公告)号：US09567604B2

公开(公告)日：2017-02-14

申请号：US14213723

申请日：2014-03-14

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung , Jeffry D. Sander , Morgan Maeder , Yanfang Fu

IPC: C07H21/02 , C12N15/00 , A61K48/00 , C12N15/85 , C12N9/22 , C12N15/63 , C07K14/005 , C07K14/195 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/96 , C12N15/01

CPC classification number: C12N15/102 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).

Abstract translation: 使用截短的引导RNA（tru-gRNA）增加RNA指导基因组编辑的特异性的方法，例如使用CRISPR / Cas9系统的编辑。

5.

发明授权
MUC16 specific chimeric antigen receptors and uses thereof 有权

公开(公告)号：US11981746B2

公开(公告)日：2024-05-14

申请号：US17650018

申请日：2022-02-04

Applicant: PRECIGEN, INC.

Inventor： Helen Sabzevari , Rutul Shah

IPC: C07K16/30 , A61K9/00 , A61K35/17 , A61K38/00 , A61K39/00 , A61P35/00 , C07K14/005 , C07K14/54 , C07K14/705 , C07K14/71 , C07K14/725 , C12N5/0783 , C12N7/00

CPC classification number: C07K16/3092 , A61K9/0019 , A61K35/17 , A61P35/00 , C07K14/005 , C07K14/5434 , C07K14/5443 , C07K14/7051 , C07K14/70521 , C07K14/70578 , C07K14/71 , C12N5/0636 , C12N7/00 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33 , C12N2770/00033

Abstract: Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-MUC16 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.

6.

发明公开
Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing 审中-公开

公开(公告)号：US20230407341A1

公开(公告)日：2023-12-21

申请号：US18178675

申请日：2023-03-06

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung , Jeffry D. Sander , Morgan Maeder , Yanfang Fu

IPC: C12N15/90 , C12N9/22 , C12N15/63 , C12N15/85 , C07K14/005 , C07K14/195 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/10 , C12N15/11

CPC classification number: C12N15/907 , C12N9/22 , C12N15/63 , C12Y301/21004 , C12N15/85 , C07K14/005 , C07K14/195 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C07K2319/00 , C07K2319/01 , C12N2710/00033 , C12N2770/00033 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12N2800/80 , C12N2310/20 , C07K2319/80

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).

7.

发明公开
PIC1 INHIBITION OF MYELOPEROXIDASE OXIDATIVE ACTIVITY IN AN ANIMAL MODEL 审中-公开

公开(公告)号：US20230321201A1

公开(公告)日：2023-10-12

申请号：US18332026

申请日：2023-06-09

Applicant: REALTA HOLDINGS, LLC

Inventor： Neel K. KRISHNA , Kenji Cunnion

IPC: A61K38/43 , A61P37/06 , A61K47/10 , A61K9/00 , A61K38/00 , A61K38/08 , C07K14/47 , C07K14/005

CPC classification number: A61K38/43 , A61P37/06 , A61K47/10 , A61K9/0019 , A61K38/005 , A61K38/08 , C07K14/4703 , C07K14/005 , C12N2770/00022 , C12N2770/00033

Abstract: A method of treating systemic lupus erythematosus in a subject is provided in which a therapeutically effective amount of PIC1 is administered to the subject. A method of treating transfusion-related acute lung injury is also provided where a therapeutically effective amount of PIC1 is administered to the subject. PIC1 can modulate immune complex activation of the complement system and NET formation in the subject. PIC1 can also inhibit myeloperoxidase (MPO) activity in the subject.

8.

发明申请
Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing 有权
Title translation: 使用RNA引导的FokI核酸酶（RFN）提高RNA引导型基因组编辑的特异性

公开(公告)号：US20140295556A1

公开(公告)日：2014-10-02

申请号：US14213479

申请日：2014-03-14

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： J. Keith Joung , Shengdar Tsai

IPC: C12N9/22 , C12N15/63

CPC classification number: C12N15/102 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

Abstract translation: 提高RNA指导基因组编辑特异性的方法，例如使用CRISPR / Cas9系统进行编辑。