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1.发明申请NOVEL MYCOVIRUS, ATTENUATED STRAIN OF PHYTOPATHOGENIC FUNGUS, PLANT DISEASE CONTROLLING AGENT, METHOD OF PRODUCING MYCOVIRUS, METHOD OF ATTENUATING PHYTOPATHOGENIC FUNGUS AND METHOD OF CONTROLLING PLANT DISEASE 有权新型MYCOVIRUS，植物病原真菌的减毒菌株，植物病害控制剂，生产MYCOVIRUS的方法，降低植物病原真菌的方法和控制植物病害的方法公开(公告)号：US20110020289A1
公开(公告)日：2011-01-27
申请号：US12863707
申请日：2009-01-05
CPC分类号： A01N63/02 , C07K14/005 , C12N7/00 , C12N2720/00021 , C12N2720/00022 , C12N2720/00061
摘要： The present invention provides a novel mycovirus that suppresses phytopathogenic fungi and a novel method for controlling plant diseases. A novel mycovirus that is present endogenously in a predetermined rice blast fungus, has four types of double-stranded RNAs of 2.8 to 3.6 kb, and suppresses a phytopathogenic fungus has been found. This virus suppresses phytopathogenic fungi such as rice blast fungus.
摘要翻译： 本发明提供抑制植物病原真菌的新型真菌病毒和控制植物病害的新方法。 在预定的稻瘟病真菌中内生存在的新型真菌病毒具有2.8〜3.6kb的4种双链RNA，抑制了植物病原真菌。 这种病毒抑制植物病原真菌如稻瘟病真菌。
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2.发明申请VIRUSES ASSOCIATED WITH IMMUNODEFICIENCY AND ENTEROPATHY AND METHODS USING SAME 有权与免疫缺陷病毒和肠系膜炎相关的病毒及其使用方法公开(公告)号：US20150284814A1
公开(公告)日：2015-10-08
申请号：US14429559
申请日：2013-09-19
发明人： Dan Barouch , Herbert W. Virgin , David Wang , Guoyan Zhao , Larissa Thackray , Scott Handley , Rachel Presti
IPC分类号： C12Q1/70
CPC分类号： C12Q1/703 , A61K39/00 , C12N7/00 , C12N2710/10321 , C12N2710/20021 , C12N2710/22021 , C12N2720/00021 , C12N2750/14021 , C12N2750/14121 , C12N2770/16021 , C12N2770/32021 , C12N2770/32321 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
摘要翻译： 本发明涉及与慢病毒感染期间病毒，免疫缺陷和肠病的显着扩张相关的先前未描述的病毒。 本发明还提供了检测受试者中获得性免疫缺陷综合征（AIDS）或AIDS进展的方法，以及诊断受试者中的免疫缺陷或肠病的方法，以及鉴定治疗药物的方法。
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公开(公告)号：US09683268B2
公开(公告)日：2017-06-20
申请号：US14429559
申请日：2013-09-19
发明人： Dan Barouch , Herbert W Virgin , David Wang , Guoyan Zhao , Larissa Thackray , Scott Handley , Rachel Presti
IPC分类号： C12Q1/70 , A61K39/235 , A61K39/21 , C12N7/00 , A61K39/00
CPC分类号： C12Q1/703 , A61K39/00 , C12N7/00 , C12N2710/10321 , C12N2710/20021 , C12N2710/22021 , C12N2720/00021 , C12N2750/14021 , C12N2750/14121 , C12N2770/16021 , C12N2770/32021 , C12N2770/32321 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
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公开(公告)号：US20170044555A1
公开(公告)日：2017-02-16
申请号：US15236144
申请日：2016-08-12
发明人： Robert C. Brown , Kurt I. Kamrud
IPC分类号： C12N15/81 , C12N9/62 , C12N15/113 , C07K14/745 , A61K39/29 , C12N7/00 , C07K16/10 , C07K14/005 , C12N15/62 , A61K39/00
CPC分类号： C12N15/81 , A61K39/0005 , A61K39/292 , A61K2039/53 , C07K14/005 , C07K14/43509 , C07K14/745 , C07K16/1018 , C07K2317/14 , C07K2317/24 , C12N7/00 , C12N9/62 , C12N9/78 , C12N15/62 , C12N2720/00021 , C12N2720/00034 , C12N2720/00043 , C12Y305/04023
摘要： The present invention provides compositions and methods for the production and delivery of recombinant double-stranded RNA molecules (dsRNA) encoding heterologous proteins, which can be useful for various therapeutic purposes as well as for the production of desired proteins. The compositions contain engineered double-stranded RNA particles (dsRPs) that can contain a double-stranded RNA molecule that can be a genome or portion of a genome, which can be enclosed in a capsid or coat protein. The dsRNA molecule also comprises an RNA sub-sequence that encodes a heterologous protein. The dsRPs can be derived from wild-type viral organisms. The delivery of the dsRPs (or DNA or RNA molecules) of the invention to an organism provides for therapeutic benefits as well as for the production of desired proteins.
摘要翻译： 本发明提供用于生产和递送编码异源蛋白质的重组双链RNA分子（dsRNA）的组合物和方法，其可用于各种治疗目的以及用于产生所需蛋白质。 组合物含有工程化的双链RNA颗粒（dsRP），其可以含有双链RNA分子，其可以是可以封装在衣壳或外壳蛋白质中的基因组或基因组的一部分。 dsRNA分子还包含编码异源蛋白质的RNA亚序列。 dsRP可以衍生自野生型病毒生物。 将本发明的dsRP（或DNA或RNA分子）递送至生物体提供治疗益处以及产生所需蛋白质。
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5.发明申请MYCOVIRUS, PLANT-PATHOGENIC FUNGUS, PLANT DISEASE CONTROL AGENT, METHOD FOR CONTROLLING PLANT DISEASE, AND METHOD FOR ATTENUATING PLANT-PATHOGENIC FUNGUS 审中-公开MYCOVIRUS，植物病原真菌，植物病害控制剂，控制植物病害的方法，以及降低植物病原真菌的方法公开(公告)号：US20140037586A1
公开(公告)日：2014-02-06
申请号：US14001476
申请日：2012-02-24
CPC分类号： A01N63/04 , A01N63/00 , C07K14/08 , C12N1/14 , C12N7/00 , C12N2720/00021 , C12N2720/00031 , C12R1/645
摘要： It is intended to exert a higher control effect on plant-pathogenic fungi. The mycovirus of the present invention has 5 types of double-stranded RNAs, wherein 4 types of double-stranded RNAs out of the 5 types of double-stranded RNAs have 81%, 75%, 72%, and 73% or higher homologies to the nucleotide sequences represented by SEQ ID NOs: 1 to 4, respectively. As an example, a novel mycovirus MoCV3 is used.
摘要翻译： 旨在对植物致病真菌施加更高的控制效果。 本发明的真菌病毒具有5种双链RNA，其中5种双链RNA中的4种双链RNA分别具有81％，75％，72％和73％以上的同源性 分别由SEQ ID NO：1至4表示的核苷酸序列。 例如，使用新型的mycovirus MoCV3。
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6.发明授权Mycovirus, attenuated strain of phytopathogenic fungus, plant disease controlling agent, method of producing mycovirus, method of attenuating phytopathogenic fungus and method of controlling plant disease 有权真菌病毒，植物病原真菌的减毒株，植物病害控制剂，产生真菌病毒的方法，减毒植物病原真菌的方法及防治植物病害的方法公开(公告)号：US08187609B2
公开(公告)日：2012-05-29
申请号：US12863707
申请日：2009-01-05
CPC分类号： A01N63/02 , C07K14/005 , C12N7/00 , C12N2720/00021 , C12N2720/00022 , C12N2720/00061
摘要： The present invention provides a novel mycovirus that suppresses phytopathogenic fungi and a novel method for controlling plant diseases. A novel mycovirus that is present endogenously in a predetermined rice blast fungus, has four types of double-stranded RNAs of 2.8 to 3.6 kb, and suppresses a phytopathogenic fungus has been found. This virus suppresses phytopathogenic fungi such as rice blast fungus.
摘要翻译： 本发明提供抑制植物病原真菌的新型真菌病毒和控制植物病害的新方法。 在预定的稻瘟病真菌中内生存在的新型真菌病毒具有2.8〜3.6kb的4种双链RNA，抑制了植物病原真菌。 这种病毒抑制植物病原真菌如稻瘟病真菌。
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