公开(公告)号：US11680259B2

公开(公告)日：2023-06-20

申请号：US15930678

申请日：2020-05-13

申请人： North Carolina State University

发明人： Rodolphe Barrangou ,  Claudio Hidalgo-Cantabrana

IPC分类号： C12N15/10 ,  C12N15/90 ,  C12N9/22 ,  C12N1/04 ,  C12N15/03 ,  C12N15/74

CPC分类号： C12N15/102 ,  C12N1/04 ,  C12N9/22 ,  C12N15/03 ,  C12N15/746 ,  C12N15/90 ,  C12N2310/20 ,  C12N2795/00061

摘要： This invention relates to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type I-E CASCADE complexes as well as plasmids, retroviruses and bacteriophage comprising the same.

公开(公告)号：US20180327721A1

公开(公告)日：2018-11-15

申请号：US16033679

申请日：2018-07-12

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： C12N5/26 ,  C12Q1/6897 ,  C12N15/03 ,  C12N9/88 ,  C12N5/00 ,  C12N5/16 ,  C12N1/00 ,  C12N15/02

CPC分类号： C12N5/166 ,  C12N1/00 ,  C12N5/00 ,  C12N5/16 ,  C12N9/88 ,  C12N15/02 ,  C12N15/03 ,  C12Q1/6897 ,  C12Y406/01001

摘要： The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.

公开(公告)号：US20180236141A1

公开(公告)日：2018-08-23

申请号：US15898482

申请日：2018-02-17

申请人： The Texas A&M University System ,  ECM Technologies, LLC

发明人： Brooke Russell ,  Magnus Hook ,  David McQuillan

IPC分类号： A61L31/04 ,  C07K14/78 ,  C12N15/03 ,  C12N15/62 ,  A61K9/19

CPC分类号： A61L31/044 ,  A61K9/06 ,  A61K9/08 ,  A61K9/12 ,  A61K9/122 ,  A61K9/19 ,  A61K9/7007 ,  A61L15/44 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/424 ,  A61L2420/02 ,  C07K14/78 ,  C12N15/03 ,  C12N15/62 ,  Y02A50/401 ,  Y02A50/423 ,  Y02A50/478

摘要： The present invention includes a synthetic collagen that facilitates adhesion prevention and methods of use thereof. The present invention includes a prokaryotic collagen that facilitates adhesion prevention and treatment and methods of use thereof. The prokaryotic collagen includes an isolated and purified triple helical backbone protein that facilitates adhesion prevention: one or more alteration in a triple helical backbone protein sequence, and one or more binding motifs, wherein the isolated and purified triple helical backbone protein facilitates adhesion prevention.

公开(公告)号：US09814790B2

公开(公告)日：2017-11-14

申请号：US15594594

申请日：2017-05-13

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： C12N1/20 ,  A61K49/00 ,  G01N33/50 ,  A61K51/12

CPC分类号： A61K49/0097 ,  A01K67/0275 ,  A01K2207/05 ,  A61B5/05 ,  A61K49/08 ,  A61K49/1896 ,  A61K51/1203 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N5/16 ,  C12N5/163 ,  C12N5/166 ,  C12N15/03 ,  C12N2510/00 ,  C12Q1/02 ,  C12Q1/6897 ,  G01N33/5005 ,  G01N33/5091 ,  G01N2469/00

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.

公开(公告)号：US09657358B2

公开(公告)日：2017-05-23

申请号：US15263144

申请日：2016-09-12

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： C12Q1/68 ,  G01N33/50 ,  C12Q1/02 ,  A01K67/027 ,  A61N2/12 ,  A61B5/05 ,  A61K49/18 ,  C12N15/03 ,  A61K49/00 ,  A61K51/12 ,  C12N5/16 ,  A61K49/08 ,  C12N5/26 ,  B82Y5/00 ,  B82Y15/00

CPC分类号： A61K49/0097 ,  A01K67/0275 ,  A01K2207/05 ,  A61B5/05 ,  A61K49/08 ,  A61K49/1896 ,  A61K51/1203 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N5/16 ,  C12N5/163 ,  C12N5/166 ,  C12N15/03 ,  C12N2510/00 ,  C12Q1/02 ,  C12Q1/6897 ,  G01N33/5005 ,  G01N33/5091 ,  G01N2469/00

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.

公开(公告)号：US20160376670A1

公开(公告)日：2016-12-29

申请号：US15263144

申请日：2016-09-12

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： C12Q1/68 ,  C12N15/03 ,  A61K49/18 ,  C12N5/26

CPC分类号： A61K49/0097 ,  A01K67/0275 ,  A01K2207/05 ,  A61B5/05 ,  A61K49/08 ,  A61K49/1896 ,  A61K51/1203 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N5/16 ,  C12N5/163 ,  C12N5/166 ,  C12N15/03 ,  C12N2510/00 ,  C12Q1/02 ,  C12Q1/6897 ,  G01N33/5005 ,  G01N33/5091 ,  G01N2469/00

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.

公开(公告)号：US09446154B2

公开(公告)日：2016-09-20

申请号：US15079453

申请日：2016-03-24

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： C12Q1/02 ,  A61K49/18 ,  G01N33/50 ,  A01K67/027 ,  A61N2/12 ,  A61B5/05 ,  C12N15/03 ,  A61K49/00 ,  A61K51/12 ,  C12N5/16 ,  A61K49/08 ,  B82Y5/00 ,  B82Y15/00

CPC分类号： A61K49/0097 ,  A01K67/0275 ,  A01K2207/05 ,  A61B5/05 ,  A61K49/08 ,  A61K49/1896 ,  A61K51/1203 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N5/16 ,  C12N5/163 ,  C12N5/166 ,  C12N15/03 ,  C12N2510/00 ,  C12Q1/02 ,  C12Q1/6897 ,  G01N33/5005 ,  G01N33/5091 ,  G01N2469/00

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.

公开(公告)号：US20160199518A1

公开(公告)日：2016-07-14

申请号：US15079453

申请日：2016-03-24

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： A61K49/18 ,  A61K49/08

CPC分类号： A61K49/0097 ,  A01K67/0275 ,  A01K2207/05 ,  A61B5/05 ,  A61K49/08 ,  A61K49/1896 ,  A61K51/1203 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N5/16 ,  C12N5/163 ,  C12N5/166 ,  C12N15/03 ,  C12N2510/00 ,  C12Q1/02 ,  C12Q1/6897 ,  G01N33/5005 ,  G01N33/5091 ,  G01N2469/00

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.

公开(公告)号：US09315780B2

公开(公告)日：2016-04-19

申请号：US14689987

申请日：2015-04-17

申请人： Bell Biosystems, Inc.

发明人： Caleb B. Bell, III ,  Alexey Bazarov

IPC分类号： C12N15/03 ,  C12N5/16 ,  G01N33/50 ,  C12Q1/02 ,  A01K67/027 ,  A61N2/12 ,  A61B5/05 ,  A61K49/18 ,  A61K49/00 ,  A61K51/12 ,  B82Y5/00 ,  B82Y15/00

CPC分类号： A61K49/0097 ,  A01K67/0275 ,  A01K2207/05 ,  A61B5/05 ,  A61K49/08 ,  A61K49/1896 ,  A61K51/1203 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N5/16 ,  C12N5/163 ,  C12N5/166 ,  C12N15/03 ,  C12N2510/00 ,  C12Q1/02 ,  C12Q1/6897 ,  G01N33/5005 ,  G01N33/5091 ,  G01N2469/00

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.

公开(公告)号：US20150007359A1

公开(公告)日：2015-01-01

申请号：US14489316

申请日：2014-09-17

申请人： BELL BIOSYSTEMS, INC.

发明人： Caleb B. BELL, III ,  Alexey Bazarov

IPC分类号： A01K67/027

CPC分类号： A61K49/0047 ,  A01K67/0275 ,  A61B5/05 ,  A61B5/055 ,  A61K49/1896 ,  A61N2/12 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/03 ,  C12Q1/02 ,  G01N21/6486 ,  G01N33/5005 ,  G01N33/574 ,  G01N2333/195 ,  G01N2333/43595

摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

摘要翻译： 本发明一般涉及包含单细胞生物的真核细胞，其通过人类干预被引入真核细胞，并通过至少五个细胞分裂转移到真核细胞的子细胞，以及引入这种单细胞生物的方法 进入真核细胞。 本发明还提供了使用这种真核细胞的方法。 本发明还提供了将单核细胞生物体引入到保留在子细胞中的真核细胞的表型。 本发明另外提供含有磁力细菌的真核细胞。