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    SMB Process
    3.
    发明申请
    SMB Process 有权
    SMB流程

    公开(公告)号：US20140194636A1

    公开(公告)日：2014-07-10

    申请号：US13880150

    申请日：2012-07-06

    Applicant: Adam Kelliher ,  Angus Morrison ,  Anil Oroskar ,  Rakesh Vikraman Nair Rema ,  Abhilesh Agarwal

    Inventor： Adam Kelliher ,  Angus Morrison ,  Anil Oroskar ,  Rakesh Vikraman Nair Rema ,  Abhilesh Agarwal

    IPC: B01D15/18 ,  C11B3/10

    CPC classification number: B01D15/185 ,  B01D15/1892 ,  C11B3/10 ,  C11B7/0008 ,  C11B7/0033 ,  C11C1/005 ,  C11C1/007

    Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product being separated from different components of the feed mixture in each zone, and wherein the aqueous organic solvent is other than aqueous alcohol.

    Abstract translation: 本发明提供了一种用于从进料混合物中回收多不饱和脂肪酸（PUFA）产物的色谱分离方法，该方法包括将进料混合物引入到具有多个连接色谱柱的模拟或实际移动床层析装置中， 洗脱剂，水性有机溶剂，其中所述装置具有包括至少第一区和第二区的多个区，每个区具有提取物流和可从所述多个连接的色谱柱从其中收集液体的萃余液流，以及 其中（a）从第一区中的塔收集含有PUFA产物和更极性组分的萃余液流，并将其引入第二区中的不相邻的塔，和/或（b）含有PUFA产物的萃取物流在一起 从第二区域的塔中收集较少的极性组分，并将其引入到fi中的不相邻的塔 所述PUFA产品与每个区域中的进料混合物的不同组分分离，并且其中所述含水有机溶剂不是含水醇。

    New SMB Process
    4.
    发明申请
    New SMB Process 有权
    新的SMB流程

    公开(公告)号：US20140128627A1

    公开(公告)日：2014-05-08

    申请号：US13880145

    申请日：2012-07-06

    Applicant: Adam Kelliher ,  Angus Morrison ,  Anil Oroskar ,  Rakesh Vikraman Nair Rema ,  Abhilesh Agarwal

    Inventor： Adam Kelliher ,  Angus Morrison ,  Anil Oroskar ,  Rakesh Vikraman Nair Rema ,  Abhilesh Agarwal

    IPC: C11C1/00

    CPC classification number: C11B3/10 ,  B01D15/1821 ,  B01D15/185 ,  B01D15/1892 ,  C11B7/0008 ,  C11B7/0025 ,  C11C1/005 ,  C11C1/007

    Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the PUFA product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first and second separation steps such that the PUFA product is separated from different components of the feed mixture in each separation step; or (b) the first and second separation steps are carried out on separate first and second chromatography apparatuses respectively, the intermediate product obtained from the first separation step being introduced into the second chromatography apparatus, and the PUFA product being separated from different components of the feed mixture in each separation step.

    Abstract translation: 本发明提供了用于从进料混合物中回收多不饱和脂肪酸（PUFA）产物的色谱分离方法，该方法包括以下步骤：（i）在模拟或实际移动床层析中在第一分离步骤中纯化进料混合物 具有多个连接的色谱柱的装置，其包含含水有机溶剂作为洗脱剂，以获得中间产物; 和（ii）使用具有多个相连的色谱柱的模拟或实际移动床层析装置，在第二分离步骤中纯化在（i）中获得的中间产物，所述色谱柱含有水性有机溶剂作为洗脱液，得到PUFA产物; 其中（a）第一和第二分离步骤在相同的色谱装置上依次进行，中间产物在第一和第二分离步骤之间回收，色谱装置中的工艺条件在第一和第二分离步骤之间进行调整， 在每个分离步骤中将PUFA产物与进料混合物的不同组分分离; 或（b）第一和第二分离步骤分别在分离的第一和第二色谱装置上进行，将从第一分离步骤获得的中间产物引入第二色谱装置中，并将PUFA产物从 进料混合物。

    METHOD FOR PRODUCING CONJUGATED LINOLEIC ACID
    5.
    发明申请
    METHOD FOR PRODUCING CONJUGATED LINOLEIC ACID 有权
    生产连结的亚麻酸的方法

    公开(公告)号：US20140113968A1

    公开(公告)日：2014-04-24

    申请号：US13976734

    申请日：2011-12-21

    Applicant: Jeroen Monster ,  Youchun Yan

    Inventor： Jeroen Monster ,  Youchun Yan

    IPC: A23D7/04 ,  A61K31/201

    CPC classification number: A23D7/04 ,  A61K31/201 ,  C11B7/0075 ,  C11C1/005 ,  C11C1/007 ,  C11C1/08 ,  C11C3/14

    Abstract: A method for producing a composition comprising conjugated linoleic acid in an amount of at least 55% by weight, comprises: (i) providing a liquid mixture comprising, as the free acids, from 50 to 95% by weight conjugated linoleic acid and at least 5% by weight of saturated C12-C22 fatty acids; (ii) cooling the liquid mixture to a temperature at which at least a part of the saturated C12-C22 fatty acids precipitate from the mixture as a solid; and (iii) separating the solid from the liquid, wherein the liquid obtained in (iii) comprises conjugated linoleic acid in an amount of at least 55% by weight.

    Abstract translation: 制备包含至少55重量％的共轭亚油酸的组合物的方法包括：（i）提供液体混合物，其包含作为游离酸的50至95重量％的共轭亚油酸和至少 5％（重量）饱和C 12 -C 22脂肪酸; （ii）将液体混合物冷却至至少一部分饱和C 12 -C 22脂肪酸作为固体从混合物中沉淀出的温度; 和（iii）从液体中分离固体，其中在（iii）中获得的液体包含至少55重量％的共轭亚油酸。

    Process for extracting a substance or a substance group from a mixture
    7.
    发明授权
    Process for extracting a substance or a substance group from a mixture 有权
    从混合物中提取物质或物质组的方法

    公开(公告)号：US08293932B2

    公开(公告)日：2012-10-23

    申请号：US11479538

    申请日：2006-06-30

    Applicant: Rudolf Krumbholz ,  Peter Lembke

    Inventor： Rudolf Krumbholz ,  Peter Lembke

    IPC: C11B3/00

    CPC classification number: C11C1/007 ,  B01D15/14 ,  B01D15/18 ,  B01D15/40 ,  C11B1/104

    Abstract: A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.

    Abstract translation: 从混合物中提取物质或物质组的方法利用溶剂进行分离。 在作为固定相的吸附剂存在下，用溶剂处理该混合物，其中溶剂通过混合物或逆流反应混合物的并流流过吸附剂，或其中溶剂 经过不动的混合物和吸附剂。 选择溶剂和吸附剂使得吸附剂的保持作用在分离过程期间支持溶剂分离和/或随后通过与作为流动相的溶剂相互作用补充分离。

    Isolation of stearidonic acid from fatty acid mixtures
    8.
    发明授权
    Isolation of stearidonic acid from fatty acid mixtures 失效
    从脂肪酸混合物分离硬脂酸

    公开(公告)号：US5130449A

    公开(公告)日：1992-07-14

    申请号：US521311

    申请日：1990-05-09

    Applicant: Michel Lagarde ,  Helmut Traitler ,  Hans-Juergen Wille

    Inventor： Michel Lagarde ,  Helmut Traitler ,  Hans-Juergen Wille

    IPC: C07C51/42 ,  C11C1/00

    CPC classification number: C11C1/007 ,  C07C51/42

    Abstract: Substantially pure stearidonic acid is isolated from a mixture of polyunsaturated fatty acids by fractionating at 25% to 35% by weight solution of fatty acids by high-performance reverse-phase liquid chromatography using a mobile phase of 75% to 95% by weight methanol and 25% to 5% by weight water. The isolated stearidonic acid is used to prepare pharmaceutical compositions which are administered to treat cardiovascular and thrombo-embolic diseases associated with platelet aggregation.

    Abstract translation: 通过使用75％至95％重量的甲醇的流动相的高性能反相液相色谱法在25％至35％重量的脂肪酸溶液中分馏从多不饱和脂肪酸的混合物中分离出基本上纯的十八碳四烯酸， 25％至5％重量的水。 分离的十八碳四烯酸用于制备药物组合物，其被施用以治疗与血小板聚集相关的心血管和血栓栓塞性疾病。

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