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    Bis-anthracenyl chiroptical compositions
    3.
    发明授权
    Bis-anthracenyl chiroptical compositions 失效
    双蒽烯基手性组合物

    公开(公告)号：US07679078B2

    公开(公告)日：2010-03-16

    申请号：US11078965

    申请日：2005-03-10

    申请人： Robert R. Schumaker ,  James J. Marek, Jr. ,  James Parakka

    发明人： Robert R. Schumaker ,  James J. Marek, Jr. ,  James Parakka

    IPC分类号： H01L29/08 ,  C07D339/02

    CPC分类号： C07D339/00

    摘要： Optoelectronic materials are provided that are bistable organic tautomeric compositions that intraconvert dithio or diseleno carbamate esters and cyclic 1,3-dithia- or -diselena-2-iminium salts of π-conjugated bis-anthracenyl compounds. Specifically disclosed are compounds having the formula: where X is sulfur or selenium; where the R and R1 groups are alkyl or alkyl that together form a ring of carbon atoms; where An is the anion of a strong acid; and where the Z element is a chiral ring-completing system of atoms that changes chirality on tautomerization. These molecules are in themselves molecular-sized optoelectronic switching devices.

    摘要翻译： 提供了光电材料，其是双稳态有机互变异构体，其包含二硫代氨基甲酸酯或二硒代氨基甲酸酯和环状1,3-二硫或 - 联苯胺-2-亚胺鎓盐和共轭双 - 蒽基化合物。 具体公开的是具有下式的化合物：其中X是硫或硒; 其中R和R 1基团是一起形成碳原子环的烷基或烷基; 其中An是强酸的阴离子; 并且其中Z元素是在互变异构化上改变手性的原子的手性环完成体系。 这些分子本身就是分子尺寸的光电开关器件。

    Bis-anthracenyl chiroptical compositions
    4.
    发明申请
    Bis-anthracenyl chiroptical compositions 失效
    双蒽烯基手性组合物

    公开(公告)号：US20060202193A1

    公开(公告)日：2006-09-14

    申请号：US11078965

    申请日：2005-03-10

    申请人： Robert Schumaker ,  James Marek ,  James Parakka

    发明人： Robert Schumaker ,  James Marek ,  James Parakka

    IPC分类号： H01L29/08 ,  C07D339/02

    CPC分类号： C07D339/00

    摘要： Optoelectronic materials are provided that are bistable organic tautomeric compositions that intraconvert dithio or diseleno carbamate esters and cyclic 1,3-dithia- or -diselena-2-iminium salts of π-conjugated bis-anthracenyl compounds. Specifically disclosed are compounds having the formula: where X is sulfur or selenium; where the R and R1 groups are alkyl or alkyl that together form a ring of carbon atoms; where An is the anion of a strong acid; and where the Z element is a chiral ring-completing system of atoms that changes chirality on tautomerization. These molecules are in themselves molecular-sized optoelectronic switching devices.

    摘要翻译： 提供了光电子材料，其是双键有机互变异构体，其包含二硫代或二硒代氨基甲酸酯和π-共轭双 - 蒽基化合物的环状1,3-二硫或 - 二烯 - 亚胺鎓盐。 具体公开的是具有下式的化合物：其中X是硫或硒; 其中R和R 1个基团是一起形成碳原子环的烷基或烷基; 其中A N是强酸的阴离子; 并且其中Z元素是在互变异构化上改变手性的原子的手性环完成体系。 这些分子本身就是分子尺寸的光电开关器件。

    Polycyclic diazodioxide-based Bcl-2 protein antagonists and use thereof
    5.
    发明申请
    Polycyclic diazodioxide-based Bcl-2 protein antagonists and use thereof 审中-公开
    基于多环二氧化二氮的Bcl-2蛋白拮抗剂及其应用

    公开(公告)号：US20040248877A1

    公开(公告)日：2004-12-09

    申请号：US10837220

    申请日：2004-04-30

    发明人： Sandeep Gupta ,  David Michael Carrig ,  Raghavan Rajagopalan ,  Prabhavathi Fernandes

    IPC分类号： A61K031/551 ,  A61K031/553

    CPC分类号： C07D401/12 ,  C07D245/04 ,  C07D339/00

    摘要： Compounds of Formula 8 are provided: 1 A and B are each independently selected from the group consisting of nullNOnull, nullSOnull, and nullNR9null. C is a single bond or a double bond. D is selected from the group consisting of single bond, 2 E is selected from the group consisting of single bond, double bond, nullNR9null, nullOnull, nullSnull, nullSOnull, and nullSO2null; and m and n are each independently an integer from 0 to 6. R1 to R9 are appropriately selected to optimize physicochemical and/or biological properties such as lipophilicity, bioavailability, pharmacokinetics, Bcl-2 and Bcl-XL activities, metabolism, and the like. R1 and R2, R2 and R3, R3 and R4, R5 and R6, R6 and R7, or R7 and R8 may optionally be joined together to form an aromatic or heteroaromatic ring, including, but not limited to, naphthyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl, benzothiazolyl and the like. The compounds are useful for tumor therapeutic applications. These compounds induce apoptosis in tumor cells mediated through Bcl-2 family of proteins.

    摘要翻译： 提供式8的化合物：A和B各自独立地选自-NO - ， - SO - 和-NR 9 - 。 C是单键或双键。 D选自单键，E选自单键，双键，-NR 9 - ， - O - ， - S - ， - SO-和-SO 2 - ; - 并且m和n各自独立地为0至6的整数.R 1至R 9适当地选择以优化物理化学和/或生物学性质，例如亲脂性，生物利用度，药代动力学，Bcl-2和Bcl-XL活性 ，新陈代谢等。 R 1和R 2，R 2和R 3，R 3和R 4，R 5和R 6，R 6和R 7， 或R 7和R 8可以任选地连接在一起形成芳族或杂芳族环，包括但不限于萘基，喹啉基，异喹啉基，苯并咪唑基，苯并恶唑基，苯并噻唑基等。 这些化合物可用于肿瘤治疗应用。 这些化合物诱导通过蛋白Bcl-2家族介导的肿瘤细胞凋亡。