公开(公告)号：US07195772B2

公开(公告)日：2007-03-27

申请号：US10312521

申请日：2001-10-19

申请人： Xiongfei Zeng ,  Jiang Zeng ,  Yan Zeng

发明人： Xiongfei Zeng ,  Jiang Zeng ,  Yan Zeng

IPC分类号： A01N25/00 ,  C07C323/00

CPC分类号： A01N59/12 ,  A23K20/147 ,  A23K20/30 ,  C07C229/00

摘要： An amino-acid iodine complex, viz. amino-acid amino-carboxyl iodine complex, was provided wherein its coordinate center is iodine molecule, complex reagent is amino-acid, sites of complexing reaction are amino and carboxyl groups of amino-acid. The complex can be used for the production of feedstuff, food additive, disinfectant, antiseptic and medicament. Also provided is a method for the production of said complex comprising opening the inner-complex ring of amino-acid by acid catalysis and allowing the amino-acid to combine with iodine molecule to form an amino-acid amino-carboxyl iodine complex; because amino-acid is a nutriment and amino-carboxyl complex is achieved, their introduction not only increases the nutritional function of the complex and improves the stability of iodine, but also is beneficial to the environment protection and enhances the disinfecting activity against viruses and bacteria.

摘要翻译： 氨基酸碘复合物，即 氨基酸氨基羧基碘络合物，其配位中心为碘分子，复合试剂为氨基酸，络合反应位点为氨基酸和氨基酸羧基。 该复合物可用于生产饲料，食品添加剂，消毒剂，防腐剂和药物。 还提供了制备所述复合物的方法，包括通过酸催化打开氨基酸的内复合环，并使氨基酸与碘分子结合形成氨基酸氨基羧基碘络合物; 由于氨基酸是一种营养成分，氨基羧基复合物的实现，不仅增加了复合物的营养功能，提高了碘的稳定性，而且有利于环境保护，增强了对病毒和细菌的杀菌活性 。

公开(公告)号：US5914319A

公开(公告)日：1999-06-22

申请号：US522825

申请日：1995-09-01

申请人： Aaron L. Schacht ,  Gerald F. Smith ,  Michael R. Wiley

发明人： Aaron L. Schacht ,  Gerald F. Smith ,  Michael R. Wiley

IPC分类号： A61K38/00 ,  A61P7/02 ,  C07C229/00 ,  C07D271/06 ,  C07D271/12 ,  C07D285/08 ,  C07D285/14 ,  C07D417/00 ,  C07D498/00 ,  C07D513/00 ,  C07F9/02 ,  C07F9/28 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

CPC分类号： A61K38/00 ,  C07C229/00 ,  C07D271/06 ,  C07D271/12 ,  C07D285/08 ,  C07D285/14 ,  C07D417/00 ,  C07D498/00 ,  C07D513/00 ,  C07F9/02 ,  C07F9/28 ,  C07K17/00 ,  C07K5/00 ,  C07K7/00

摘要： This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.

摘要翻译： 本发明涉及具有式I XY-NH-（CH2）r-GI的凝血酶抑制化合物，其中X，Y，r和G具有描述中定义的值，以及含有这些化合物的药物制剂及其用途的方法 凝血酶抑制剂，凝血抑制剂和血栓栓塞障碍剂。

公开(公告)号：US20230338317A1

公开(公告)日：2023-10-26

申请号：US17818951

申请日：2022-08-10

申请人： Orbus Therapeutics, Inc.

发明人： Victor A. LEVIN ,  Noymi YAM ,  Alexander VAKOULA

IPC分类号： A61K31/197 ,  A61K9/00 ,  A61K47/26 ,  A61P43/00 ,  A61P35/00 ,  C07C229/00 ,  A61P25/00

CPC分类号： A61K31/197 ,  A61K9/0053 ,  A61K47/26 ,  A61P43/00 ,  A61P35/00 ,  A61K9/0095 ,  C07C229/00 ,  A61P25/00

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.

公开(公告)号：US5202466A

公开(公告)日：1993-04-13

申请号：US922486

申请日：1992-07-31

申请人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

发明人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

IPC分类号： C07C229/00

CPC分类号： C07C229/00

摘要： 2-amino-7-hydroxytetraline ethers of formula ##STR1## wherein R' represents methyl substituted by a carboxy group or lower carbalkoxy group or a salt thereof; a process for their preparation starting from the 2-amino-7-hydroxytetraline, N-protection, O-alkylation and N-deprotection; N-protected intermediates; and use of the compounds I for the preparation of the corresponding phenylethanolaminotetralines.

摘要翻译： 其中R'表示被羧基或低级烷氧羰基取代的甲基或其盐的2-氨基-7-羟基四氢化萘， 从2-氨基-7-羟基四氢化萘，N-保护，O-烷基化和N-去保护开始制备其制备方法。 N-保护的中间体; 以及使用化合物I制备相应的苯基乙醇胺三酰四氢呋喃。

公开(公告)号：US20040198974A1

公开(公告)日：2004-10-07

申请号：US10486200

申请日：2004-02-13

发明人： Kurt Guenther ,  Stefan Merget ,  Karlheinz Drauz ,  Hans-Peter Krimmer ,  Michael Schwarm

IPC分类号： C07D267/22 ,  C07D281/18 ,  C07D291/00 ,  C07D337/16 ,  C07D487/00 ,  C07D498/00 ,  C07D513/00

CPC分类号： C07C269/08 ,  C07B2200/07 ,  C07C227/34 ,  C07C229/00 ,  C07C271/22

摘要： The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is performed for industrial scale production of pure enantiomers of deemed amino acids which are useful intermediates in organic synthesis. 1

摘要翻译： 本发明涉及分离式（I）的外消旋体的对映异构体。 通过将视觉外消旋物应用于像SMB这样的连续对映选择性色谱法进行分离。 这些方法主要用于工业规模生产被认为是有机合成中有用的中间体的被认为的氨基酸的纯对映异构体。

公开(公告)号：US5017480A

公开(公告)日：1991-05-21

申请号：US211268

申请日：1988-06-24

申请人： Shigenori Mori ,  Kinzo Iitani ,  Masaki Yamamoto ,  Masashi Miyazawa ,  Toyokazu Kaneko ,  Tetsuya Kaneko ,  Ken-ich Yarita

发明人： Shigenori Mori ,  Kinzo Iitani ,  Masaki Yamamoto ,  Masashi Miyazawa ,  Toyokazu Kaneko ,  Tetsuya Kaneko ,  Ken-ich Yarita

IPC分类号： C12P13/04 ,  B01D61/14 ,  C07C67/00 ,  C07C227/00 ,  C07C227/28 ,  C07C227/40 ,  C07C229/00 ,  C07C231/00 ,  C07C231/24 ,  C07C237/06 ,  C07D209/20 ,  C07D233/64

CPC分类号： B01D61/14 ,  C07C227/00 ,  C07C227/28 ,  C07C227/40 ,  C07C229/00 ,  C07C231/00 ,  C07C231/24 ,  C07C237/06 ,  C07C67/00 ,  C07D209/20 ,  C07D233/64 ,  C12P13/04

摘要： A process for recovering a high-purity L-amino acid from a fermentation liquor obtained by fermentation or an enzymic method, which comprises removing the impurities contained in said fermentation liquor by passing said fermentation liquor through an ultrafilter membrane and then through an ion-exchange or adsorbent resin; concentrating or cooling the effluent thus obtained to result in crystallization of said L-amino acid, and isolating said crystalline L-amino acid from said fermentation liquor.

摘要翻译： 从通过发酵或酶法获得的发酵液中回收高纯度L-氨基酸的方法，其包括通过使所述发酵液通过超滤膜然后通过离子交换来除去所述发酵液中所含的杂质 或吸附树脂; 浓缩或冷却由此获得的流出物导致所述L-氨基酸的结晶，并从所述发酵液中分离所述结晶L-氨基酸。

公开(公告)号：US20090306228A1

公开(公告)日：2009-12-10

申请号：US11933846

申请日：2007-11-01

申请人： Travis Mickle ,  Suma Krishnan ,  James Scott Moncrief ,  Christopher Lauderback ,  Thomas Piccariello ,  Randal Kirk

发明人： Travis Mickle ,  Suma Krishnan ,  James Scott Moncrief ,  Christopher Lauderback ,  Thomas Piccariello ,  Randal Kirk

IPC分类号： A61K47/16 ,  C07C229/00

CPC分类号： C07C229/00 ,  A61K47/542

摘要： The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

公开(公告)号：US20030171598A1

公开(公告)日：2003-09-11

申请号：US10312521

申请日：2003-02-10

发明人： Xiongfei Zeng ,  Jiang Zeng ,  Yan Zeng

IPC分类号： C07D233/64 ,  C07C229/40

CPC分类号： A01N59/12 ,  A23K20/147 ,  A23K20/30 ,  C07C229/00

摘要： An amino-acid iodine complex, viz. amino-acid amino-carboxyl iodine complex, was provided wherein its coordinate center is iodine molecule, complex reagent is amino-acid, sites of complexing reaction are amino and carboxyl groups of amino-acid. The complex can be used for the production of feedstuff, food additive, disinfectant, antiseptic and medicament. Also provided is a method for the production of said complex comprising opening the inner-complex ring of amino-acid by acid catalysis and allowing the amino-acid to combine with iodine molecule to form an amino-acid amino-carboxyl iodine complex; because amino-acid is a nutriment and amino-carboxyl complex is achieved, their introduction not only increases the nutritional function of the complex and improves the stability of iodine, but also is beneficial to the environment protection and enhances the disinfecting activity against viruses and bacteria.

摘要翻译： 氨基酸碘复合物，即 氨基酸氨基羧基碘络合物，其配位中心为碘分子，复合试剂为氨基酸，络合反应位点为氨基酸和氨基酸羧基。 该复合物可用于生产饲料，食品添加剂，消毒剂，防腐剂和药物。 还提供了制备所述复合物的方法，包括通过酸催化打开氨基酸的内复合环，并使氨基酸与碘分子结合形成氨基酸氨基羧基碘络合物; 由于氨基酸是一种营养成分，氨基羧基复合物的实现，不仅增加了复合物的营养功能，提高了碘的稳定性，而且有利于环境保护，增强了对病毒和细菌的杀菌活性 。

公开(公告)号：US5214196A

公开(公告)日：1993-05-25

申请号：US763188

申请日：1991-09-20

申请人： Izhak Blank

发明人： Izhak Blank

IPC分类号： C07C229/00

CPC分类号： C07C229/00

摘要： The invention comprises compositions and methods for the treatment of psoriasis. The compositions comprise compounds of the formula: ##STR1##

摘要翻译： 本发明包括用于治疗牛皮癣的组合物和方法。 组合物包含下式的化合物：