公开(公告)号：US20190133985A1

公开(公告)日：2019-05-09

申请号：US16169642

申请日：2018-10-24

申请人： Orbus Therapeutics, Inc.

发明人： Victor A. LEVIN

IPC分类号： A61K31/198 ,  A61K31/175 ,  A61K31/221 ,  A61K31/133 ,  A61K45/06 ,  A61P35/00

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors. Eflornithine or derivatives or analogs thereof can also be used to treat a range of non-glioma malignancies, including both malignancies of the central nervous system and other malignancies.

公开(公告)号：US20170273926A1

公开(公告)日：2017-09-28

申请号：US15218149

申请日：2016-07-25

申请人： Orbus Therapeutics, Inc.

发明人： Victor A. LEVIN

IPC分类号： A61K31/198 ,  A61K31/475 ,  A61K31/166 ,  A61K9/00 ,  A61K31/17

CPC分类号： A61K31/198 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/166 ,  A61K31/17 ,  A61K31/175 ,  A61K31/475 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors.

公开(公告)号：US20210038549A1

公开(公告)日：2021-02-11

申请号：US17002117

申请日：2020-08-25

申请人： Orbus Therapeutics, Inc.

发明人： Victor A. LEVIN ,  Noymi YAM ,  Alexander VAKOULA

IPC分类号： A61K31/197 ,  A61P25/00 ,  A61P35/00 ,  A61K9/00 ,  A61P43/00 ,  C07C229/00 ,  A61K47/26

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the elformithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.

公开(公告)号：US20200138758A1

公开(公告)日：2020-05-07

申请号：US16339664

申请日：2017-09-29

申请人： Orbus Therapeutics, Inc

发明人： Victor A. LEVIN ,  Noymi YAM ,  Alexander VAKOULA

IPC分类号： A61K31/197 ,  A61K9/00

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.

公开(公告)号：US20230338317A1

公开(公告)日：2023-10-26

申请号：US17818951

申请日：2022-08-10

申请人： Orbus Therapeutics, Inc.

发明人： Victor A. LEVIN ,  Noymi YAM ,  Alexander VAKOULA

IPC分类号： A61K31/197 ,  A61K9/00 ,  A61K47/26 ,  A61P43/00 ,  A61P35/00 ,  C07C229/00 ,  A61P25/00

CPC分类号： A61K31/197 ,  A61K9/0053 ,  A61K47/26 ,  A61P43/00 ,  A61P35/00 ,  A61K9/0095 ,  C07C229/00 ,  A61P25/00

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.

公开(公告)号：US20190091187A1

公开(公告)日：2019-03-28

申请号：US16087195

申请日：2017-03-16

申请人： Orbus Therapeutics, Inc.

发明人： Victor A. LEVIN

IPC分类号： A61K31/198 ,  A61K45/06 ,  A61K9/00 ,  A61P35/00

摘要： Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors.