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25 条记录 (耗时 0.013 秒)

    Process for the separation of L-leucine and L-isoleucine
    5.
    发明授权
    Process for the separation of L-leucine and L-isoleucine 失效
    分离L-亮氨酸和L-异亮氨酸的方法

    公开(公告)号：US4731476A

    公开(公告)日：1988-03-15

    申请号：US32370

    申请日：1987-03-31

    申请人： Kris Bart de Roos

    发明人： Kris Bart de Roos

    IPC分类号： C12P13/06 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/28 ,  C07C227/40 ,  C07C229/00 ,  C07C229/04 ,  C07C99/12

    CPC分类号： C07C227/28 ,  C07C227/38 ,  C12P13/06

    摘要： The invention relates to a process for the separation of L-leucine and L-isoleucine. The process is carried out by subjecting a mixture of leucine ester, and isoleucine ester, (or a mixture of leucine ester, isoleucine ester and valine ester) to an esterase catalyzed hydrolysis resulting in a selective hydrolysis of the leucine ester. The pure L-leucine can be isolated from the reaction mixture by first removing the non-hydrolyzed esters by extraction with an organic solvent and then crystallizing the L-leucine at its isoelectric point. The recovered L-iso-leucine ester is purified by distillation (if necessary), and hydrolyzed to yield pure crystalline L-isoleucine.

    Method of Making 6-Aminocaproic Acid As Active Pharmaceutical Ingredient
    7.
    发明申请
    Method of Making 6-Aminocaproic Acid As Active Pharmaceutical Ingredient 有权
    制备6-氨基己酸作为活性药物成分的方法

    公开(公告)号：US20140039219A1

    公开(公告)日：2014-02-06

    申请号：US13660126

    申请日：2012-10-25

    申请人： Jien-Heh Tien ,  Chu-yi Pang

    发明人： Jien-Heh Tien ,  Chu-yi Pang

    IPC分类号： C07C227/22

    CPC分类号： C07C227/22 ,  C07C227/38

    摘要： The present invention provides a method for making 6-aminocaproic acid as an active pharmaceutical ingredient. The method comprises: performing a hydrolysis procedure to have ε-caprolactam react with acid or base to generate a first reaction mixture, performing a modification procedure to have a solubility regulating agent reacts with 6-aminocaproic acid in the first reaction mixture to form a second reaction mixture including an aminocaproic acid intermediate, performing a separation procedure to have the intermediate separated from the second reaction mixture and performing a hydrogenation procedure to have the aminocaproic acid intermediate hydrogenated to form a 6-aminocaproic acid product.

    摘要翻译： 本发明提供了制备6-氨基己酸作为活性药物成分的方法。 该方法包括：进行水解步骤以使ε-己内酰胺与酸或碱反应以产生第一反应混合物，进行修饰方法以使第一反应混合物中的溶解度调节剂与6-氨基己酸反应形成第二反应混合物 反应混合物包括氨基己酸中间体，进行分离步骤以使中间体与第二反应混合物分离，并进行氢化方法使氨基己酸中间体氢化形成6-氨基己酸产物。