摘要:
A continuous flow particle separation system for separating metallic and nonmetallic particles from a mixed-particle suspension includes a fluid channeling component defining an input channel and first and second output channels fluidly connected to the input channel at a bifurcated junction, a first electrode and a second electrode arranged proximate the input channel at least partially prior to the bifurcated junction, and an alternating current (AC) electric power source electrically connected to the first and second electrodes. The first and second electrodes have shapes configured to provide a spatially-gradient electric field across the input channel, and the AC electric power source is configured to provide an AC electric potential to the first and second electrodes to cause a separation of the metallic and nonmetallic particles by dielectrophoresis due to a difference in dielectrophoretic forces imposed on the metallic particles relative to those of the nonmetallic particles such that first output fluid flow in the first output channel has an enriched concentration of metallic particles and second output fluid flow in the second output channel has an enriched concentration of nonmetallic particles relative to the mixed-particle suspension in said input channel.
摘要:
Certain exemplary embodiments can provide a method, which can comprise isolating a single molecule of a solid organic compound via a microencapsulation process. The single molecule can be adapted for use in at least one of a drug, pharmaceutical application, microelectronic device, bioengineering application, biomedical product, agricultural product, or agricultural medicine. The microencapsulation process can comprise (1) adsorbing the single molecule on a template; and (2) dividing the template into species using electrostatic charge generating molecules.
摘要:
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
摘要:
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
摘要:
The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.
摘要:
Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
摘要:
An apparatus and method are provided for separating electrically neutral solid materials having different dielectric, shape, density or dipole moment properties by passing a mixture of such materials through a nonuniform electric field generated between an electrically charged arcuate surface and a flat horizontal grounded surface having a receiving end, a discharge end and two lateral edges, said arcuate surface being spaced above said horizontal surface and extending from about said receiving end to about said discharge end and from one of said lateral edges to at least midway between said lateral edges; a means for introducing said solid materials into the electric field near said receiving end and conducting said material through the field to said discharge end; and recovering one type of material from said lateral edge adjacent said arcuate surface and another type of material from said discharge end of the horizontal surface.
摘要:
A separator of particulate material by the use of electric fields is comprised of a pair of spaced plates of a dielectric material between which particulate material is arranged to be fed, the material being propelled in a given direction by a vibratory feeder attached to the lowermost plate. A set of parallel spaced electrodes are provided on each of said plates out of contact with the material and extending in a direction laterally of said given direction, and an AC voltage is applied between the sets of electrodes so that alternating electrical fields are set up at spaced locations along said plates in said given direction. Certain of said particulate material is caused to be repelled by said electrical fields and deflected thereby to move in said direction laterally of said given direction while the remainder of said material moves generally in said given direction.