公开(公告)号：US10585096B2

公开(公告)日：2020-03-10

申请号：US15031793

申请日：2014-10-24

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Sam Emaminejad ,  Mehdi Javanmard ,  Chaitanya Gupta ,  Roger T. Howe

IPC分类号： G01N33/543

摘要： Embodiments of the present disclosure provide for systems of enhancing the signal to noise ratio, methods of orienting a nanomaterial (e.g., an antibody), methods of enhancing the signal to noise ratio in a system (e.g., an assay system), and the like.

公开(公告)号：US09981273B2

公开(公告)日：2018-05-29

申请号：US14042585

申请日：2013-09-30

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Mehdi Javanmard ,  Sam Emaminejad ,  Janine Mok ,  Michael N. Mindrinos

IPC分类号： B03C7/02 ,  B81B1/00 ,  B03C5/00 ,  B03C5/02

CPC分类号： B03C7/023 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  B81B1/006

摘要： The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.

公开(公告)号：US20140102901A1

公开(公告)日：2014-04-17

申请号：US14042585

申请日：2013-09-30

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Mehdi Javanmard ,  Sam Emaminejad ,  Janine Mok ,  Michael N. Mindrinos

IPC分类号： B03C7/02 ,  B81B1/00

CPC分类号： B03C7/023 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  B81B1/006

摘要： The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.

摘要翻译： 介电电泳（介电电泳或DEP）的过程利用在施加正（有吸引力）和/或负（排斥）施加力的情况下移动的场极化粒子。 本发明在微通道分离装置内使用负电介质电泳（负介电电泳或nDEP）来使颗粒移动（分离）或保持静止（附着）。 在本发明的一个实施方案中，所产生的nDEP力足够强大以分离出约400pN（piconewtons）的Ag-Ab（抗原 - 抗体）键，同时保持系统组分的完整性。

公开(公告)号：US20170262694A1

公开(公告)日：2017-09-14

申请号：US15456240

申请日：2017-03-10

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Audrey K. Bowden ,  Nicholas Dwork ,  Mehdi Javanmard ,  Saara Anwar Khan ,  Kiran Rana Magar ,  Matthew Alexander Millet ,  Gennifer Tanabe Smith

IPC分类号： G06K9/00 ,  G06K9/20 ,  G06T7/90 ,  G06T7/80 ,  G01N33/18 ,  G01N21/25 ,  G01N21/27 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G02B21/36 ,  G06T7/73

CPC分类号： G01N33/18 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0267 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/50 ,  G01J3/52 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N2021/7759 ,  G01N2201/064 ,  G02B21/008 ,  G02B21/34 ,  G02B21/365 ,  G06K9/00127

摘要： Improved colorimetric analysis of liquid samples is provided. A sample holder is used that delivers predetermined volumes of sample individually to each of several colorimetric test patches at the same time with a sliding action. An opaque housing is employed to prevent ambient light from reaching the test patches when color images of the test patches are acquired. Preferably, a mobile electronic device including a camera is attached to the opaque housing to acquire the images. Optical microscopy can be performed in addition to the colorimetric analysis.