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公开(公告)号：US10400266B2
公开(公告)日：2019-09-03
申请号：US15171027
申请日：2016-06-02
IPC分类号： C12Q1/6806 , G01N33/53 , G01N33/543 , G01N33/574 , G01N33/68 , C12N15/10 , B03C7/02 , C12Q1/6837
摘要： Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
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公开(公告)号：US20130323742A1
公开(公告)日：2013-12-05
申请号：US13968907
申请日：2013-08-16
CPC分类号： C12Q1/6806 , B03C7/023 , C12N15/1003 , C12N15/101 , C12Q1/6837 , G01N33/5308 , G01N33/543 , G01N33/574 , G01N33/689 , G01N2800/385 , C12Q2527/146 , C12Q2537/164 , C12Q2565/125
摘要： Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
摘要翻译： 提供了基于与探针结合亲和力的差异来分离，浓缩和/或检测分子的方法和装置。 分子可以进行差异修饰。 分子可以是差异甲基化的核酸。 该方法可用于诸如表观遗传学或肿瘤学等领域以选择性地浓缩或检测特异性生物分子或差异修饰的生物分子的存在，以提供诸如胎儿遗传疾病之类的病症的诊断，以检测癌症中的生物标志物，器官衰竭，疾病状态， 感染等。
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公开(公告)号：US10829800B2
公开(公告)日：2020-11-10
申请号：US16514690
申请日：2019-07-17
IPC分类号： C12Q1/68 , C12Q1/6806 , G01N33/53 , G01N33/543 , G01N33/574 , G01N33/68 , C12N15/10 , B03C7/02 , C12Q1/6837
摘要： Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
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公开(公告)号：US20190338342A1
公开(公告)日：2019-11-07
申请号：US16514690
申请日：2019-07-17
IPC分类号： C12Q1/6806 , B03C7/02 , C12N15/10 , G01N33/574 , G01N33/68 , G01N33/543 , G01N33/53 , C12Q1/6837
摘要： Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
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公开(公告)号：US20160289744A1
公开(公告)日：2016-10-06
申请号：US15171027
申请日：2016-06-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B03C7/023 , C12N15/1003 , C12N15/101 , C12Q1/6837 , G01N33/5308 , G01N33/543 , G01N33/574 , G01N33/689 , G01N2800/385 , C12Q2527/146 , C12Q2537/164 , C12Q2565/125
摘要： Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
摘要翻译： 提供了基于与探针结合亲和力的差异来分离，浓缩和/或检测分子的方法和装置。 分子可以进行差异修饰。 分子可以是差异甲基化的核酸。 该方法可用于诸如表观遗传学或肿瘤学等领域以选择性地浓缩或检测特异性生物分子或差异修饰的生物分子的存在，以提供诸如胎儿遗传疾病之类的病症的诊断，以检测癌症中的生物标志物，器官衰竭，疾病状态， 感染等。
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公开(公告)号：US09434938B2
公开(公告)日：2016-09-06
申请号：US13968907
申请日：2013-08-16
IPC分类号： C12N15/10 , G01N33/53 , G01N33/543 , G01N33/574 , G01N33/68 , C12Q1/68 , B03C7/02
CPC分类号： C12Q1/6806 , B03C7/023 , C12N15/1003 , C12N15/101 , C12Q1/6837 , G01N33/5308 , G01N33/543 , G01N33/574 , G01N33/689 , G01N2800/385 , C12Q2527/146 , C12Q2537/164 , C12Q2565/125
摘要： Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.
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