公开(公告)号：US11912693B2

公开(公告)日：2024-02-27

申请号：US16613152

申请日：2018-06-12

申请人： TREVENA, INC.

发明人： Philip Michael Pitis ,  Robert Eugene Boyd ,  Tamara Ann Miskowski Daubert ,  Michael John Hawkins ,  Guodong Liu ,  Aimee Crombie Speerschneider

IPC分类号： A61P25/02 ,  A61P35/00 ,  C07D413/14 ,  C07D413/04 ,  C07D405/14

CPC分类号： C07D413/04 ,  A61P25/02 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

公开(公告)号：US20210061812A1

公开(公告)日：2021-03-04

申请号：US16486539

申请日：2018-02-15

申请人： Trevena, Inc.

发明人： Aimee CROMBIE SPEERSCHNEIDER ,  Dennis SHINJI YAMASHITA ,  Philip Michael PITIS ,  Michael John HAWKINS ,  Guodong Liu ,  Tamara Ann MISKOWSKI DAUBERT ,  Catherine C.K. YUAN ,  Robert BORBO KARGBO ,  Robert Jason HERR ,  Donna ROMERO

IPC分类号： C07D487/08 ,  A61P23/00 ,  A61P25/24 ,  A61P25/22 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D223/04

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US09518086B2

公开(公告)日：2016-12-13

申请号：US14616487

申请日：2015-02-06

申请人： Trevena, Inc.

发明人： Ritesh Sanghvi ,  Gregory Alcorn ,  Graham Richard Lawton ,  Meiki Yu ,  Matthew Ronsheim ,  Jiaher Tian ,  Shao Hong Zhou ,  Yuriy B. Kalyan

IPC分类号： C07K7/06 ,  A61K38/00

CPC分类号： C07K7/64 ,  A61K38/00 ,  A61K38/12 ,  C07K7/06

摘要： The present disclosure provides novel crystalline forms of a compound that acts as a β-arrestin effector, processes for preparing novel crystalline and amorphous forms of a compound that acts as a β-arrestin effector and uses thereof.

摘要翻译： 本公开提供了作为β-抑制蛋白效应子的化合物的新型结晶形式，用于制备作为β-抑制蛋白效应物的化合物的新型结晶和无定形形式的用途及其应用。

公开(公告)号：US08796204B2

公开(公告)日：2014-08-05

申请号：US13926766

申请日：2013-06-25

申请人： Trevena, Inc.

发明人： Dennis Yamashita ,  Xiao-Tao Chen

IPC分类号： A61K38/00 ,  A61P13/12 ,  A61P9/00 ,  C07K7/06 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/08 ,  A61K45/06 ,  C07K7/14

摘要： This application describes a family of compounds acting as β-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases.

摘要翻译： 本申请描述了一系列化合物作为＆amp; bastar-效应物。 这些化合物可以在治疗慢性和急性心血管疾病方面提供显着的治疗益处。

公开(公告)号：US20130331408A1

公开(公告)日：2013-12-12

申请号：US13964505

申请日：2013-08-12

申请人： Dennis Yamashita ,  Dimitar Gotchev ,  Philip Pitis ,  Xiao-Tao Chen ,  Guodong Liu ,  Catherine C.K. Yuan

发明人： Dennis Yamashita ,  Dimitar Gotchev ,  Philip Pitis ,  Xiao-Tao Chen ,  Guodong Liu ,  Catherine C.K. Yuan

IPC分类号： C07D405/12 ,  A61K31/444 ,  C07D405/14 ,  A61K31/4433 ,  A61K45/06

CPC分类号： A61K31/4436 ,  A61K9/0019 ,  A61K31/35 ,  A61K31/4433 ,  A61K31/444 ,  A61K45/06 ,  C07D311/96 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

摘要： This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.

摘要翻译： 本申请描述了可以作为阿片受体配体的化合物，该化合物可用于治疗例如疼痛和疼痛相关疾病。

公开(公告)号：US20240317728A1

公开(公告)日：2024-09-26

申请号：US18495083

申请日：2023-10-26

申请人： Trevena, Inc.

发明人： Brian H. Heasley ,  Jennifer Wilent ,  Patrick J. Koestler

IPC分类号： C07D413/14

CPC分类号： C07D413/14 ,  C07B2200/13

摘要： The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.

公开(公告)号：US20220348588A1

公开(公告)日：2022-11-03

申请号：US17532413

申请日：2021-11-22

申请人： Trevena, Inc.

发明人： Aimee CROMBIE SPEERSCHNEIDER ,  Dennis SHINJI YAMASHITA ,  Philip Michael PITIS ,  Michael John HAWKINS ,  Guodong Liu ,  Tamara Ann MISKOWSKI DAUBERT ,  Catherine C.K. YUAN ,  Robert BORBO KARGBO ,  Robert Jason HERR ,  Donna ROMERO

IPC分类号： C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11465980B2

公开(公告)日：2022-10-11

申请号：US16286700

申请日：2019-02-27

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D241/04 ,  C07D451/02 ,  C07D211/22

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11225487B2

公开(公告)日：2022-01-18

申请号：US16486539

申请日：2018-02-15

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC分类号： C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US10246436B2

公开(公告)日：2019-04-02

申请号：US15252112

申请日：2016-08-30

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： A61K31/445 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14 ,  C07D241/04 ,  C07D403/12 ,  C07D405/14 ,  C07D451/02

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.