公开(公告)号：US20240317728A1

公开(公告)日：2024-09-26

申请号：US18495083

申请日：2023-10-26

申请人： Trevena, Inc.

发明人： Brian H. Heasley ,  Jennifer Wilent ,  Patrick J. Koestler

IPC分类号： C07D413/14

CPC分类号： C07D413/14 ,  C07B2200/13

摘要： The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.

公开(公告)号：US20220348588A1

公开(公告)日：2022-11-03

申请号：US17532413

申请日：2021-11-22

申请人： Trevena, Inc.

发明人： Aimee CROMBIE SPEERSCHNEIDER ,  Dennis SHINJI YAMASHITA ,  Philip Michael PITIS ,  Michael John HAWKINS ,  Guodong Liu ,  Tamara Ann MISKOWSKI DAUBERT ,  Catherine C.K. YUAN ,  Robert BORBO KARGBO ,  Robert Jason HERR ,  Donna ROMERO

IPC分类号： C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11465980B2

公开(公告)日：2022-10-11

申请号：US16286700

申请日：2019-02-27

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D241/04 ,  C07D451/02 ,  C07D211/22

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11225487B2

公开(公告)日：2022-01-18

申请号：US16486539

申请日：2018-02-15

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC分类号： C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US10246436B2

公开(公告)日：2019-04-02

申请号：US15252112

申请日：2016-08-30

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： A61K31/445 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14 ,  C07D241/04 ,  C07D403/12 ,  C07D405/14 ,  C07D451/02

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20170333385A1

公开(公告)日：2017-11-23

申请号：US15378930

申请日：2016-12-14

申请人： Trevena, Inc.

发明人： Conrad Cowan ,  Michael Koblish ,  Michael W. Lark

IPC分类号： A61K31/35 ,  A61K45/06 ,  A61K31/4436 ,  C07D409/12 ,  A61K31/4433

CPC分类号： A61K31/35 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/485 ,  A61K45/06 ,  C07D409/12 ,  A61K2300/00

摘要： This application describes compounds and methods that can be used to treat, reverse, or avoid hyperalgesia.

公开(公告)号：US20140357562A1

公开(公告)日：2014-12-04

申请号：US14461081

申请日：2014-08-15

申请人： Trevena, Inc.

发明人： Dennis Yamashita ,  Xiao-Tao Chen

IPC分类号： C07K7/06 ,  A61K38/08 ,  A61K45/06

CPC分类号： C07K7/06 ,  A61K38/08 ,  A61K45/06 ,  C07K7/14

摘要： This application describes a family of compounds acting as β-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases.

公开(公告)号：US11912693B2

公开(公告)日：2024-02-27

申请号：US16613152

申请日：2018-06-12

申请人： TREVENA, INC.

发明人： Philip Michael Pitis ,  Robert Eugene Boyd ,  Tamara Ann Miskowski Daubert ,  Michael John Hawkins ,  Guodong Liu ,  Aimee Crombie Speerschneider

IPC分类号： A61P25/02 ,  A61P35/00 ,  C07D413/14 ,  C07D413/04 ,  C07D405/14

CPC分类号： C07D413/04 ,  A61P25/02 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

公开(公告)号：US20210061812A1

公开(公告)日：2021-03-04

申请号：US16486539

申请日：2018-02-15

申请人： Trevena, Inc.

发明人： Aimee CROMBIE SPEERSCHNEIDER ,  Dennis SHINJI YAMASHITA ,  Philip Michael PITIS ,  Michael John HAWKINS ,  Guodong Liu ,  Tamara Ann MISKOWSKI DAUBERT ,  Catherine C.K. YUAN ,  Robert BORBO KARGBO ,  Robert Jason HERR ,  Donna ROMERO

IPC分类号： C07D487/08 ,  A61P23/00 ,  A61P25/24 ,  A61P25/22 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D223/04

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20170283464A1

公开(公告)日：2017-10-05

申请号：US15345234

申请日：2016-11-07

申请人： Trevena, Inc.

发明人： Ritesh Sanghvi ,  Gregory Alcorn ,  Graham Richard Lawton ,  Meiki Yu ,  Matthew Ronsheim ,  Jiaher Tian ,  Shao Hong Zhou ,  Yuriy B. Kalyan

IPC分类号： C07K7/64 ,  C07K7/06 ,  A61K38/12

CPC分类号： C07K7/64 ,  A61K38/00 ,  A61K38/12 ,  C07K7/06

摘要： The present disclosure provides novel crystalline forms of a compound that acts as a β-arrestin effector, processes for preparing novel crystalline and amorphous forms of a compound that acts as a β-arrestin effector and uses thereof.