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公开(公告)号：US09642842B2
公开(公告)日：2017-05-09
申请号：US15093315
申请日：2016-04-07
Applicant: Trevena, Inc.
Inventor： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C. K. Yuan
IPC: A61K31/4436 , C07D405/14 , A61K31/444 , A61K45/06 , A61K31/35 , C07D311/96 , C07D405/12 , C07D409/14 , A61K31/4433 , C07D405/04 , C07D409/12 , A61K9/00
CPC classification number: A61K31/4436 , A61K9/0019 , A61K31/35 , A61K31/4433 , A61K31/444 , A61K45/06 , C07D311/96 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
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公开(公告)号：US11931350B2
公开(公告)日：2024-03-19
申请号：US17367021
申请日：2021-07-02
Applicant: TREVENA, INC.
Inventor： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C. K. Yuan
IPC: A61K31/4436 , A61K9/00 , A61K31/35 , A61K31/4433 , A61K31/444 , A61K45/06 , C07D311/96 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
CPC classification number: A61K31/4436 , A61K9/0019 , A61K31/35 , A61K31/4433 , A61K31/444 , A61K45/06 , C07D311/96 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
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公开(公告)号：US11465980B2
公开(公告)日：2022-10-11
申请号：US16286700
申请日：2019-02-27
Applicant: Trevena, Inc.
Inventor： Aimee Crombie Speerschneider , Dennis Shinji Yamashita , Philip Michael Pitis , Michael John Hawkins , Guodong Liu , Tamara Ann Miskowski Daubert , Catherine C. K. Yuan , Robert Borbo Kargbo , Robert Jason Herr , Donna Romero , Gregory J. Pacofsky
IPC: C07D401/12 , A61K31/445 , C07D403/12 , C07D401/14 , C07D405/14 , C07D241/04 , C07D451/02 , C07D211/22
Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
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公开(公告)号：US11225487B2
公开(公告)日：2022-01-18
申请号：US16486539
申请日：2018-02-15
Applicant: Trevena, Inc.
Inventor： Aimee Crombie Speerschneider , Dennis Shinji Yamashita , Philip Michael Pitis , Michael John Hawkins , Guodong Liu , Tamara Ann Miskowski Daubert , Catherine C. K. Yuan , Robert Borbo Kargbo , Robert Jason Herr , Donna Romero
IPC: C07D487/08 , A61P25/22 , A61P23/00 , A61P25/24 , C07D223/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14
Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
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公开(公告)号：US10246436B2
公开(公告)日：2019-04-02
申请号：US15252112
申请日：2016-08-30
Applicant: Trevena, Inc.
Inventor： Aimee Crombie Speerschneider , Dennis Shinji Yamashita , Philip Michael Pitis , Michael John Hawkins , Guodong Liu , Tamara Ann Miskowski Daubert , Catherine C. K. Yuan , Robert Borbo Kargbo , Robert Jason Herr , Donna Romero , Gregory J. Pacofsky
IPC: A61K31/445 , C07D211/22 , C07D401/12 , C07D401/14 , C07D241/04 , C07D403/12 , C07D405/14 , C07D451/02
Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
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公开(公告)号：US11912713B2
公开(公告)日：2024-02-27
申请号：US17532413
申请日：2021-11-22
Applicant: Trevena, Inc.
Inventor： Aimee Crombie Speerschneider , Dennis Shinji Yamashita , Philip Michael Pitis , Michael John Hawkins , Guodong Liu , Tamara Ann Miskowski Daubert , Catherine C. K. Yuan , Robert Borbo Kargbo , Robert Jason Herr , Donna Romero
IPC: C07D487/08 , A61P25/22 , A61P23/00 , A61P25/24 , C07D223/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14
CPC classification number: C07D487/08 , A61P23/00 , A61P25/22 , A61P25/24 , C07D223/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14
Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
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公开(公告)号：US11702408B2
公开(公告)日：2023-07-18
申请号：US16486541
申请日：2018-02-15
Applicant: Trevena, Inc.
Inventor： Aimee Crombie Speerschneider , Dennis Shinji Yamashita , Philip Michael Pitis , Michael John Hawkins , Guodong Liu , Tamara Ann Miskowski Daubert , Catherine C. K. Yuan , Robert Borbo Kargbo , Robert Jason Herr , Donna Romero
IPC: C07D403/12 , C07D403/14 , A61P25/22 , A61P25/24 , A61P25/06 , A61P29/00
CPC classification number: C07D403/12 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , C07D403/14
Abstract: The present embodiments are directed, in part, to 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, such as those of Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinson's Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
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公开(公告)号：US09849119B2
公开(公告)日：2017-12-26
申请号：US15472345
申请日：2017-03-29
Applicant: TREVENA, INC.
Inventor： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C. K. Yuan
IPC: A61K31/4436 , C07D405/14 , A61K31/444 , A61K45/06 , A61K31/35 , C07D311/96 , C07D405/12 , C07D409/14 , A61K31/4433 , C07D405/04 , C07D409/12 , A61K9/00
CPC classification number: A61K31/4436 , A61K9/0019 , A61K31/35 , A61K31/4433 , A61K31/444 , A61K45/06 , C07D311/96 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
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公开(公告)号：US11077098B2
公开(公告)日：2021-08-03
申请号：US15828695
申请日：2017-12-01
Applicant: TREVENA, INC.
Inventor： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C. K. Yuan
IPC: A61K31/4436 , A61K9/00 , A61K45/06 , A61K31/444 , A61K31/4433 , A61K31/35 , C07D409/14 , C07D405/14 , C07D405/12 , C07D405/04 , C07D311/96 , C07D409/12
Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
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公开(公告)号：US10588898B2
公开(公告)日：2020-03-17
申请号：US16522008
申请日：2019-07-25
Applicant: TREVENA, INC.
Inventor： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C. K. Yuan
IPC: A61K31/4436 , A61K45/06 , A61K31/444 , A61K31/4433 , A61K31/35 , A61K9/00 , C07D409/12 , C07D409/14 , C07D405/14 , C07D405/12 , C07D405/04 , C07D311/96
Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
