公开(公告)号：US11465980B2

公开(公告)日：2022-10-11

申请号：US16286700

申请日：2019-02-27

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC: C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D241/04 ,  C07D451/02 ,  C07D211/22

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11225487B2

公开(公告)日：2022-01-18

申请号：US16486539

申请日：2018-02-15

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC: C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US10246436B2

公开(公告)日：2019-04-02

申请号：US15252112

申请日：2016-08-30

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC: A61K31/445 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14 ,  C07D241/04 ,  C07D403/12 ,  C07D405/14 ,  C07D451/02

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20170210725A1

公开(公告)日：2017-07-27

申请号：US15252112

申请日：2016-08-30

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC: C07D401/12 ,  C07D451/02 ,  C07D405/14 ,  C07D401/14 ,  C07D211/22

CPC classification number: C07D401/12 ,  A61K31/445 ,  C07D211/22 ,  C07D241/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D451/02 ,  A61K2300/00

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20190202803A1

公开(公告)日：2019-07-04

申请号：US16286700

申请日：2019-02-27

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC: C07D401/12 ,  C07D405/14 ,  C07D403/12 ,  C07D451/02 ,  A61K31/445 ,  C07D241/04 ,  C07D211/22 ,  C07D401/14

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11912713B2

公开(公告)日：2024-02-27

申请号：US17532413

申请日：2021-11-22

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC: C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D487/08 ,  A61P23/00 ,  A61P25/22 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20230303531A1

公开(公告)日：2023-09-28

申请号：US18314913

申请日：2023-05-10

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC: C07D403/12 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  A61P25/06 ,  C07D403/14

CPC classification number: C07D403/12 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  A61P25/06 ,  C07D403/14

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11702408B2

公开(公告)日：2023-07-18

申请号：US16486541

申请日：2018-02-15

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC: C07D403/12 ,  C07D403/14 ,  A61P25/22 ,  A61P25/24 ,  A61P25/06 ,  A61P29/00

CPC classification number: C07D403/12 ,  A61P25/06 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  C07D403/14

Abstract: The present embodiments are directed, in part, to 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, such as those of Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinson's Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20230203002A1

公开(公告)日：2023-06-29

申请号：US17879923

申请日：2022-08-03

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC: C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D241/04 ,  C07D451/02 ,  C07D211/22

CPC classification number: C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D241/04 ,  C07D451/02 ,  C07D211/22

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20200231564A9

公开(公告)日：2020-07-23

申请号：US16286700

申请日：2019-02-27

Applicant: Trevena, Inc.

Inventor： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC: C07D401/12 ,  C07D405/14 ,  C07D403/12 ,  C07D451/02 ,  A61K31/445 ,  C07D241/04 ,  C07D211/22 ,  C07D401/14

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.