公开(公告)号：US20240002957A1

公开(公告)日：2024-01-04

申请号：US17998720

申请日：2021-05-13

申请人： Technion Research and Development Foundation Ltd.

发明人： Naama GEVA-ZATORSKY ,  Nadav BEN-ASSA ,  Rawi NADDAF ,  Tal GEFEN

IPC分类号： C12Q1/70 ,  B01L7/00 ,  B01L3/00

CPC分类号： C12Q1/701 ,  B01L7/52 ,  B01L3/527 ,  B01L2400/0481 ,  B01L2300/043 ,  B01L2400/0611

摘要： The present disclosure provides devices, systems, kits and methods for rapid, simple self-sampling and self-performing detection of nucleic acid sequence of interest in a sample, specifically, nucleic acid sequences of pathogenic agents.

公开(公告)号：US11826353B2

公开(公告)日：2023-11-28

申请号：US17025269

申请日：2020-09-18

申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

发明人： Tomer Shlomi ,  Won Dong Lee

IPC分类号： A61K31/4162 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K31/4162 ,  A61P35/00 ,  G01N33/57484

摘要： The invention provides a method for treating cancer in which a level of reduced folate carrier (RFC) or folylpolyglutamate synthetase (FPGS) in cancer cells of the biopsy is determined. If the level of RFC or FPGS in the cancer cells is below a threshold value, the cancer is treated with an inhibitor of serine-hydroxymethyl-transferase (SHMT)1. If the level of RFC or FPGS in the cancer cells is above the threshold value, the cancer is treated with an inhibitor of SHMT2.

公开(公告)号：US20230366105A1

公开(公告)日：2023-11-16

申请号：US18246599

申请日：2021-09-23

申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. ,  H2PRO LTD

发明人： Gideon GRADER ,  Hen DOTAN ,  Avner ROTHSCHILD ,  Avigail LANDMAN

IPC分类号： C25B1/02 ,  C25B11/031 ,  C25B11/061 ,  C25B11/067

CPC分类号： C25B1/02 ,  C25B11/031 ,  C25B11/061 ,  C25B11/067

摘要： The invention disclosed herein generally contemplates novel microelectrodes and methods of preparing same.

公开(公告)号：US20230070921A1

公开(公告)日：2023-03-09

申请号：US17447066

申请日：2021-09-08

申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

发明人： OMER SABARY ,  GUY SHAPIRA ,  EITAN YAAKOBI ,  ALEXANDER YUCOVICH

IPC分类号： G16B50/30 ,  G06N3/12

摘要： There may be provided method for estimating an information unit represented by a cluster of traces that are noisy copies of a synthesized strand, the method may include estimating the information unit by applying processing operations on r-tuples related to the traces, wherein r is smaller than a number (t) of traces of the cluster; wherein processing operations applied on at least some of the r-tuples comprise calculating a length of a shortest common supersequences (SCS) of the r-tuples.

公开(公告)号：US11138226B2

公开(公告)日：2021-10-05

申请号：US16603563

申请日：2018-04-05

申请人： Technion Research and Development Foundation Ltd.

发明人： Oded Shmueli ,  Itai Shaked

IPC分类号： G06F16/23 ,  G06F16/27 ,  G06F16/22 ,  G06Q10/06

摘要： Systems and methods are provided for moving replicas of a target data object between a plurality of storage nodes that store multiple replicated data objects, by setting new applications to a move mode, waiting for prior applications to exit before moving the target data object, determining that an indication of access to the target data object is done, and responsively copying the replicas of the target data object from first locations among the plurality of data storage nodes to second locations among the plurality of storage nodes.

公开(公告)号：US20210068667A1

公开(公告)日：2021-03-11

申请号：US16887246

申请日：2020-05-29

申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

发明人： Amir LANDESBERG ,  Anna FAINGERSH-KLEBANOV

IPC分类号： A61B5/0205 ,  A61B5/08 ,  A61B5/021 ,  A61B5/00

摘要： A method for detecting or monitoring respiratory or cardiac health of a patient includes measuring any intravascular or intracardiac pressure (IVP) of a patient over a period of time, said IVP including a measured respiratory wave, defining respiratory effort of the patient as a peak-to-peak amplitude of said respiratory wave, and using the respiratory effort to detect or monitor respiratory and cardiac health of the patient by comparing the respiratory effort with a known value of respiratory effort or by monitoring changes in the respiratory effort of the patient over another period of time.

公开(公告)号：US10890555B2

公开(公告)日：2021-01-12

申请号：US16106598

申请日：2018-08-21

申请人： Technion Research and Development Foundation LTD.

发明人： Yael Nemirovsky

IPC分类号： G01N27/414 ,  G01J5/04 ,  H01L27/144 ,  G01J5/02 ,  G01J5/06 ,  G01J5/00 ,  G01N27/16

摘要： A gas sensing device, that may include a suspended gas sensing element, a frame that supports the suspended gas sensing element, and one or more traps for trapping at least one out of Siloxane and silicon dioxide. The suspended gas sensing element may include a gas reactive element that has a gas dependent temperature parameter, and a semiconductor temperature sensing element that is thermally coupled to the gas reactive element, and is configured to generate detection signals that are responsive to a temperature of the gas reactive element. The gas reactive element and the semiconductor temperature sensing element are of microscopic scale.

公开(公告)号：US20190309300A1

公开(公告)日：2019-10-10

申请号：US16316677

申请日：2017-07-13

申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  RAMBAM MED-TECH LTD.

发明人： Izhak KEHAT ,  Alon ABEND ,  Omer SHKEDI ,  Lilac CASPI

IPC分类号： C12N15/113 ,  A61P9/10 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/713

摘要： A pharmaceutical composition and a method of treating, reducing or preventing vascular, cardiovascular arterial or valve calcification in a subject in need comprising administering to the subject an effective amount of an agent that prevents or reduces the expression of HDAC4, an agent that modulates the location of HDAC4, an agent that binds to HDAC4 or an inhibitor of HDAC4 or any combination thereof is provided. In some embodiments, there is provided a pharmaceutical composition comprising: an agent that prevents or reduces the expression of HDAC4, an agent that modulates the location of HDAC4, an agent that binds to HDAC4 or an inhibitor of HDAC4 or any combination thereof; an agent that prevents or reduces the expression of SIK or is an inhibitor of SIK; and/or an agent that prevents or reduces the expression of ENIGMA (Pdlim7) or is an inhibitor of ENIGMA.

公开(公告)号：US10011481B2

公开(公告)日：2018-07-03

申请号：US12669965

申请日：2008-07-24

申请人： Hossam Haick

发明人： Hossam Haick

IPC分类号： B82Y15/00 ,  B82Y30/00 ,  G01N33/543 ,  G01N27/414 ,  H01L29/08 ,  G01N33/00 ,  G01N33/497

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  G01N27/4146 ,  G01N33/0034 ,  G01N33/54373 ,  G01N2033/4975 ,  H01L29/0843

摘要： The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.

公开(公告)号：US09950093B2

公开(公告)日：2018-04-24

申请号：US14401014

申请日：2013-05-15

申请人： Technion Research and Development Foundation Ltd ,  National University of Singapore

发明人： Eyal Zussman ,  Srinivasa Reddy Chaganti ,  Jayarama Reddy Venugopal ,  Seeram Ramakrishna ,  Omri Regev

IPC分类号： A61F2/02 ,  A61L27/26 ,  A61L27/52 ,  A61L27/48

CPC分类号： A61L27/26 ,  A61F2/02 ,  A61L27/48 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/00 ,  Y10T428/31978 ,  C08L89/06

摘要： A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 μm. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method using the fiber-reinforced composite are also provided.