公开(公告)号：US08687891B2

公开(公告)日：2014-04-01

申请号：US12949455

申请日：2010-11-18

Applicant: Gabriel Takacs ,  Radek Grzeszczuk ,  Vijay Chandrasekhar ,  Bernd Girod

Inventor： Gabriel Takacs ,  Radek Grzeszczuk ,  Vijay Chandrasekhar ,  Bernd Girod

IPC: G06K9/46

CPC classification number: G06K9/4642 ,  G06K9/4671 ,  G06K9/527 ,  G06T7/246 ,  G06T2207/10016 ,  G06T2207/20164

Abstract: Various methods for tracking and recognition with rotation invariant feature descriptors are provided. One example method includes generating an image pyramid of an image frame, detecting a plurality of interest points within the image pyramid, and extracting feature descriptors for each respective interest point. According to some example embodiments, the feature descriptors are rotation invariant. Further, the example method may also include tracking movement by matching the feature descriptors to feature descriptors of a previous frame and performing recognition of an object within the image frame based on the feature descriptors. Related example methods and example apparatuses are also provided.

Abstract translation: 提供了用于跟踪和识别旋转不变特征描述符的各种方法。 一种示例性方法包括生成图像帧的图像金字塔，检测图像金字塔内的多个兴趣点，以及针对各个兴趣点提取特征描述符。 根据一些示例实施例，特征描述符是旋转不变量。 此外，示例性方法还可以包括通过将特征描述符与先前帧的特征描述符进行匹配来跟踪移动，并且基于特征描述符执行图像帧内的对象的识别。 还提供了相关的示例性方法和示例设备。

公开(公告)号：US20120255046A1

公开(公告)日：2012-10-04

申请号：US13472260

申请日：2012-05-15

Applicant: MARK KAY ,  Dirk Grimm

Inventor： MARK KAY ,  Dirk Grimm

IPC: A01K67/027 ,  C12N5/10

CPC classification number: C12N15/1082 ,  C07K14/005 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143

Abstract: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.

Abstract translation: 提供重组腺相关病毒（AAV）衣壳蛋白。 还提供了用于产生重组腺相关病毒衣壳蛋白文库的方法。

公开(公告)号：US20120010556A1

公开(公告)日：2012-01-12

申请号：US13241497

申请日：2011-09-23

Applicant: John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

Inventor： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

IPC: A61M1/00

CPC classification number: A61B17/11 ,  A61B5/026 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61F2/06 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

Abstract: A long-term implantable arterio-venous shunt device is provided that can be used as a therapeutic method. The shunt device is implanted between an artery and a vein, preferably between the aorta and the inferior vena cava. The shunt device decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. The blood flow rate could be controlled either via an open loop or a closed loop control means. The shunt device could also be a self-adjustable shunt device to self-adjust its structure to control the blood flow rate through its lumen. Based on the effects of the shunt device to the respiratory, cardiac and circulatory system, the implantable shunt device could be beneficial as a therapy to patients with problems or conditions related to these systems.

Abstract translation: 提供可用作治疗方法的长期可植入动静脉分流装置。 分流装置植入动脉和静脉之间，优选在主动脉和下腔静脉之间。 分流装置降低全身血管阻力，并允许植入后通过分流装置的血流速度至少为5ml / min。 可以通过开环或闭环控制装置来控制血液流量。 分流装置也可以是自调节分流装置，以自我调节其结构以控制通过其管腔的血液流速。 基于分流装置对呼吸，心脏和循环系统的影响，可植入分流装置可作为对与这些系统相关的问题或病症的患者的治疗有益。

公开(公告)号：US20110301180A1

公开(公告)日：2011-12-08

申请号：US13093825

申请日：2011-04-25

Applicant: James P. Collman ,  Paul Clifford Herrmann ,  David Alvin Tyvoll ,  Richard Decreau ,  Brian Stanley Bull ,  Christopher Jeffrey Barile

Inventor： James P. Collman ,  Paul Clifford Herrmann ,  David Alvin Tyvoll ,  Richard Decreau ,  Brian Stanley Bull ,  Christopher Jeffrey Barile

IPC: A61K31/4192 ,  C07D277/02 ,  C07F9/54 ,  C07D257/04 ,  C07D277/40 ,  C07D277/22 ,  C07D277/24 ,  C07D209/12 ,  C07D233/84 ,  C07D239/26 ,  C07D339/04 ,  A61K31/41 ,  A61K31/426 ,  A61K31/4164 ,  A61K31/404 ,  A61K31/505 ,  A61K31/385 ,  A61P7/02 ,  A61P9/10 ,  A61P9/04 ,  A61P3/00 ,  A61P9/12 ,  A61P3/10 ,  A61P9/00 ,  C07D249/06

CPC classification number: A61K31/385 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/426 ,  A61K31/505 ,  C07F9/6539

Abstract: It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.

Abstract translation: 已经发现抑制血小板中的线粒体呼吸减少血小板活化或血小板聚集。 某些杂环化合物显着降低一种或多种血小板功能，包括结块，粘附或血小板刺激的凝血。 因此，可以通过施用治疗有效量的显着降低一种或多种血小板功能的杂环化合物或非环状线粒体抑制剂来治疗由不适当高水平的血小板活化或血小板聚集介导的疾病或病症，包括结块，粘附或血小板刺激的凝血， 优选以可逆的方式。

公开(公告)号：US20110218485A1

公开(公告)日：2011-09-08

申请号：US13041284

申请日：2011-03-04

Applicant: Pelu Tran ,  Khang Trong Dinh ,  Andrew Pipathsouk ,  Benjamin Chung ,  Hongbin Li

Inventor： Pelu Tran ,  Khang Trong Dinh ,  Andrew Pipathsouk ,  Benjamin Chung ,  Hongbin Li

IPC: A61M13/00

CPC classification number: A61M13/00

Abstract: A method and apparatus are provided for a fluid level insertion indicator that provides immediate feedback to a surgeon by draining when a tip of a needle has entered a body lumen, such as peritoneal cavity. An apparatus includes a handle connected to a hollow needle and a hollow stylet that extends through the hollow needle and has a blunt distal end that includes an opening for passing fluid. A spring biases the stylet to extend past the sharp distal end of the needle absent resistance by tissue against the stylet. An at least partially translucent pressure chamber configured to hold a quantity of fluid under pressure is connected to the proximal end of the stylet. The pressure chamber and stylet form a conduit for passing fluid through the opening in the blunt distal end when the stylet extends past the sharp distal end of the hollow needle.

Abstract translation: 提供了一种用于液位插入指示器的方法和装置，其通过在针的尖端进入体腔（例如腹膜腔）时通过排水而向外科医生提供即时反馈。 一种装置包括连接到中空针的手柄和延伸穿过中空针的空心探针并具有钝的远端，该远端包括用于使流体通过的开口。 弹簧偏压探针以延伸穿过针尖的尖端，组织抵抗探针而没有阻力。 构造成在压力下保持一定量的流体的至少部分半透明的压力室连接到通球针的近端。 当探针延伸穿过中空针的尖锐远端时，压力室和探针形成一个导管，用于使流体通过钝头远端的开口。

公开(公告)号：US20110200529A1

公开(公告)日：2011-08-18

申请号：US13119721

申请日：2009-09-17

Applicant: Jianghong Rao ,  Zuyong Xia

Inventor： Jianghong Rao ,  Zuyong Xia

IPC: A61K49/00 ,  G01N21/76 ,  C12M1/34

CPC classification number: G01N33/542

Abstract: A method of use of an activatable bioluminescent probe system includes: providing a bioluminescent protein and a quencher in a reaction environment; modifying a ligand between the quencher and the bioluminescent protein using a ligand interacting molecule; adding a bioluminescence initiating molecule to the reaction environment; and measuring light originating from the interaction between the bioluminescent protein and the bioluminescence initiating molecule.

Abstract translation: 使用可激活的生物发光探针系统的方法包括：在反应环境中提供生物发光蛋白和猝灭剂; 使用配体相互作用分子修饰猝灭剂和生物发光蛋白质之间的配体; 在反应环境中加入生物发光引发分子; 并测量源自生物发光蛋白和生物发光起始分子之间相互作用的光。

公开(公告)号：US07955844B2

公开(公告)日：2011-06-07

申请号：US12398352

申请日：2009-03-05

Applicant: Sanjiv Gambhir ,  Ray Pritha

Inventor： Sanjiv Gambhir ,  Ray Pritha

IPC: C12N15/00 ,  C07H21/04 ,  C07K2/00 ,  A61K31/713 ,  A61K38/02

CPC classification number: C12N15/62 ,  A01K67/0271 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0393 ,  C07K14/43595 ,  C07K2319/00 ,  C07K2319/60 ,  C12N9/1211 ,  C12N15/8509 ,  C12N2740/15043 ,  C12N2800/40

Abstract: Novel double and triple fusion reporter gene constructs harboring distinct imagable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies.

Abstract translation: 提供了具有不同的成像报告基因的新型双重和三重融合报道基因构建体，以及使用不同成像技术在活细胞和活体动物中使用这种双重和三重融合构建体的应用。

公开(公告)号：US07842469B2

公开(公告)日：2010-11-30

申请号：US12365984

申请日：2009-02-05

Applicant: Sanjiv S. Gambhir ,  Abhijit De

Inventor： Sanjiv S. Gambhir ,  Abhijit De

IPC: G01N33/53

CPC classification number: G01N33/542 ,  C12Q1/66

Abstract: Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, methods to determine the efficacy of a test compound administered to modulate the interaction of a first protein with a second protein in a living animal, BRET vectors, kits relating to each of the above, transgenic cell or progeny thereof and/or animals relating to each of the above, and the like.

Abstract translation: 简要描述，本公开的实施方案包括生物发光共振能量转移（BRET）系统，检测蛋白质 - 蛋白质相互作用的方法，用于检测活体动物中第一种蛋白质与第二种蛋白质的相互作用的非侵入性方法，确定功效的方法 施用以调节活体动物中第一蛋白质与第二蛋白质的相互作用的测试化合物，BRET载体，与上述每种相关的试剂盒，转基因细胞或其后代和/或与上述每种相关的动物，和/或 类似。

公开(公告)号：US07835493B2

公开(公告)日：2010-11-16

申请号：US12187222

申请日：2008-08-06

Applicant: Paul J. Keall ,  Yelin Suh ,  Elisabeth Weiss

Inventor： Paul J. Keall ,  Yelin Suh ,  Elisabeth Weiss

IPC: A61N5/10 ,  H05G1/08

CPC classification number: A61N5/1042 ,  A61N5/1036 ,  A61N5/1037

Abstract: A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.

Abstract translation: 公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。 优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的肿瘤总体积（GTV）质心运动来对准每个束位置的准直器。 在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。

公开(公告)号：US20100255471A1

公开(公告)日：2010-10-07

申请号：US12657457

申请日：2010-01-20

Applicant: Michael F. Clarke ,  Stephen R. Quake ,  Piero D. Dalerba ,  Huiping Liu ,  Anne Leyrat ,  Tomer Kalisky ,  Maximilian Diehn

Inventor： Michael F. Clarke ,  Stephen R. Quake ,  Piero D. Dalerba ,  Huiping Liu ,  Anne Leyrat ,  Tomer Kalisky ,  Maximilian Diehn

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/5023 ,  G01N33/57484 ,  G01N2800/52

Abstract: Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like. Single cell analysis also provides for the identification and development of therapies which target mutations and/or pathways in disease-state cells.

Abstract translation: 通过分析从单细胞分析获得的一组基因的表达，为疾病的诊断和预后提供方法。 分类允许优化治疗，确定是否进行特定治疗，以及如何优化剂量，治疗选择等。 单细胞分析还提供了鉴定和开发针对疾病状态细胞中的突变和/或途径的疗法。