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    Modular aseptic production system
    2.
    发明授权
    Modular aseptic production system 有权

    公开(公告)号：US12043436B2

    公开(公告)日：2024-07-23

    申请号：US17896538

    申请日：2022-08-26

    申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

    发明人： Francesco Sanmartin

    IPC分类号： A61L2/04 ,  B65B3/00 ,  B65B7/28 ,  B65B43/42 ,  B65B55/02 ,  B65B59/04

    CPC分类号： B65B59/04 ,  A61L2/04 ,  B65B3/003 ,  B65B7/2821 ,  B65B43/42 ,  B65B55/025 ,  A61L2202/21

    摘要： A modular production system including a plurality of production modules connected in a linear series to form a production tunnel, and collectively defining a production channel, and wherein at least one fluid inlet port defined along the production tunnel, said inlet port is in fluid communication with a pressurized fluid source, whereby influx of fluid from said fluid source through said fluid inlet port acts to maintain the fluid pressure within the production channel at a higher pressure than the atmospheric pressure outside of the production tunnel; and wherein one of said production modules positioned between said proximal-most and distal-most production modules comprises a depyrogenator and/or sterilization module, comprising a transparent tubular body, and an irradiation source positioned external to said transparent tubular body, said irradiation source capable of heating the internal environment of the depyrogenation and/or sterilization module to a temperature sufficient to depyrogenate or sterilize articles passing therethrough, and associated processes.

    Stable cell lines for retroviral production
    8.
    发明授权
    Stable cell lines for retroviral production 有权

    公开(公告)号：US11795474B2

    公开(公告)日：2023-10-24

    申请号：US16606281

    申请日：2018-04-18

    申请人： GlaxoSmithKline Intellectual Property Development Limited

    发明人： Conrad Vink

    IPC分类号： C12N15/00 ,  C12N15/86 ,  C07K14/16

    CPC分类号： C12N15/86 ,  C07K14/161 ,  C07K14/162 ,  C12N2740/13052 ,  C12N2740/15052 ,  C12N2740/16052 ,  C12N2799/027 ,  C12N2830/003 ,  C12N2830/006 ,  C12N2830/60

    摘要： The invention relates to retroviral producer cell comprising nucleic acid sequences encoding: gag and pol proteins; envelope protein or a functional substitute thereof; amplifiable selection marker; and the RNA genome of the retroviral vector particle, wherein said nucleic acid sequences are all integrated at a single locus within the retroviral producer cell genome. The invention also relates to nucleic acid vectors comprising a non-mammalian origin of replication and the ability to hold at least 25 kilobases (kb) of DNA, characterized in that said nucleic acid vector comprises retroviral nucleic acid sequences encoding: gag and pol proteins, and an env protein or a functional substitute thereof. The nucleic acid vector additionally comprises nucleic acid sequences encoding an amplifiable selection marker. The invention also relates to uses and methods using said nucleic acid vector in order to produce stable retroviral packaging and producer cell lines.