-
公开(公告)号：US20230131598A1
公开(公告)日：2023-04-27
申请号：US17911816
申请日：2021-04-12
摘要： The invention relates to a method of treating cancer, such as head and neck cancer (e.g. head and neck squamous cell carcinoma and oropharyngeal cancer), lung cancer (e.g. non small cell lung cancer), urothelial cancer, melanoma or cervical cancer, involving the combination of an ICOS binding protein (e.g. an anti-ICOS antibody) and a TIM-3 binding protein (e.g. an anti-TIM-3 antibody) and, optionally, a PD-1 binding protein (e.g. an anti-PD-1 antibody).
-
2.发明公开公开(公告)号：US20230149543A1
公开(公告)日：2023-05-18
申请号：US17916916
申请日：2021-04-12
IPC分类号： A61K39/395 , A61K38/17 , A61P35/00
CPC分类号： A61K39/3955 , A61K38/179 , A61P35/00
摘要： The invention relates to a method of treating cancer, involving the combination of an ICOS binding protein, a PD-1 inhibitor and a TGF-β inhibitor. In particular, the invention relates to an ICOS binding protein (e.g. an anti-ICOS antibody) and a fusion protein targeting human protein Programmed Death Ligand 1 (PD-L1) or Programmed Cell Death Protein 1 (PD-1), and Transforming Growth Factor β (TGF-β) (e.g. an anti-PD-(L)1(IgG):TGFβR fusion protein, comprising, for example, an anti-PD-L1 antibody and a TGFβRII or a fragment capable of binding to TGF-β).
-
公开(公告)号：US20210324081A1
公开(公告)日：2021-10-21
申请号：US17287358
申请日：2019-10-21
IPC分类号： C07K16/28 , A61K9/00 , A61P35/00 , A61K39/395
摘要： The present invention relates to a method of treating cancer comprising administering to the human an ICOS binding protein or antigen binding portion thereof at a dose of about 0.08 mg to about 240 mg and administering to the human a PD1 antagonist.
-
公开(公告)号：US20210395367A1
公开(公告)日：2021-12-23
申请号：US17287144
申请日：2019-10-21
摘要： The present invention relates to a method of treating cancer comprising administering to the human an ICOS binding protein or antigen binding portion thereof at a dose of about 0.08 mg to about 240 mg.
-
-
-
搜索结果
4 条记录 (耗时 0.013 秒)
