公开(公告)号：US20220002780A1

公开(公告)日：2022-01-06

申请号：US17222772

申请日：2021-04-05

申请人： Caris Science, Inc.

发明人： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

IPC分类号： C12Q1/6804 ,  C12N15/11 ,  C12N15/115 ,  G01N33/68

摘要： The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.

公开(公告)号：US20200376022A1

公开(公告)日：2020-12-03

申请号：US16497024

申请日：2018-03-27

申请人： Caris Science, Inc.

发明人： Valeriy Domenyuk ,  Xianghua Liu ,  Mark Miglarese ,  David Spetzler

IPC分类号： A61K31/7125 ,  C12Q1/6811 ,  C12Q1/6886

摘要： Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include circulating biomarkers such as micro vesicles, including those derived from various diseases.

公开(公告)号：US10731166B2

公开(公告)日：2020-08-04

申请号：US16084504

申请日：2017-03-18

申请人： Caris Science, Inc.

发明人： Valeriy Domenyuk ,  Tassilo Hornung ,  Heather O'Neill ,  Mark Miglarese ,  David Spetzler

IPC分类号： C12N15/115 ,  C12N15/10 ,  C12Q1/6883 ,  C12Q1/6886

摘要： Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.

公开(公告)号：US10316349B2

公开(公告)日：2019-06-11

申请号：US15669782

申请日：2017-08-04

申请人： Caris Science, Inc.

发明人： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

IPC分类号： C12N15/115 ,  C12Q1/68 ,  C12Q1/6804 ,  C12N15/11 ,  G01N33/68

摘要： The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.

公开(公告)号：US20240247273A1

公开(公告)日：2024-07-25

申请号：US18531328

申请日：2023-12-06

申请人： Caris Science, Inc.

发明人： Heather O'Neill ,  Mark Miglarese ,  David Spetzler

IPC分类号： C12N15/115 ,  A61K31/711 ,  A61K47/68 ,  G01N33/53

CPC分类号： C12N15/115 ,  A61K31/711 ,  A61K47/6807 ,  G01N33/53 ,  C12N2310/16 ,  C12N2310/3513 ,  C12N2320/10 ,  G01N2333/4716 ,  G01N2333/70503 ,  Y02A50/30

摘要： Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.

公开(公告)号：US11725023B2

公开(公告)日：2023-08-15

申请号：US17166071

申请日：2021-02-03

申请人： Caris Science, Inc.

发明人： Heather O'Neill ,  Günter Mayer ,  Mark Miglarese ,  David Spetzler

IPC分类号： C12N15/115 ,  C07H19/173 ,  A61K47/69 ,  A61P37/00 ,  A61P25/28 ,  A61P31/00 ,  A61P9/00 ,  A61P35/02 ,  A61P29/00 ,  A61K9/00 ,  C07H19/09 ,  C07H19/19 ,  C07H21/00 ,  C12N15/10 ,  C12Q1/6886 ,  G06T7/00 ,  G01N33/574 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07H19/173 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K47/6911 ,  A61K47/6929 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P35/02 ,  A61P37/00 ,  C07H19/09 ,  C07H19/19 ,  C07H21/00 ,  C12N15/10 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/5308 ,  G01N33/57484 ,  G01N33/68 ,  G06T7/0012 ,  C12N2310/16 ,  C12N2320/10 ,  C12Q2600/158

摘要： Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.

公开(公告)号：US11624083B2

公开(公告)日：2023-04-11

申请号：US17838984

申请日：2022-06-13

申请人： Caris Science, Inc.

发明人： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

IPC分类号： C12Q1/6804 ,  C12N15/11 ,  C12N15/115 ,  G01N33/68

摘要： The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.

公开(公告)号：US10941176B2

公开(公告)日：2021-03-09

申请号：US15745407

申请日：2016-07-28

申请人： Caris Science, Inc.

发明人： Heather O'Neill ,  Günter Mayer ,  Mark Miglarese ,  David Spetzler

IPC分类号： C12N15/11 ,  C07H19/173 ,  A61K47/69 ,  A61P37/00 ,  A61P25/28 ,  A61P31/00 ,  A61P9/00 ,  A61P35/02 ,  A61P29/00 ,  A61K9/00 ,  C07H19/09 ,  C07H19/19 ,  C07H21/00 ,  C12N15/10 ,  C12N15/115 ,  C12Q1/6886 ,  G06T7/00 ,  G01N33/574 ,  G01N33/53 ,  G01N33/68

摘要： Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.

公开(公告)号：US20210062191A1

公开(公告)日：2021-03-04

申请号：US16897976

申请日：2020-06-10

申请人： Caris Science, Inc.

发明人： Valeriy Domenyuk ,  Tassilo Hornung ,  Heather O'Neill ,  Mark Miglarese ,  David Spetzler

IPC分类号： C12N15/115 ,  C12N15/10 ,  C12Q1/6883 ,  C12Q1/6886

摘要： Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.

公开(公告)号：US12116618B2

公开(公告)日：2024-10-15

申请号：US17222772

申请日：2021-04-05

申请人： Caris Science, Inc.

发明人： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

IPC分类号： C12Q1/6804 ,  C12N15/11 ,  C12N15/115 ,  G01N33/68

CPC分类号： C12Q1/6804 ,  C12N15/111 ,  C12N15/115 ,  G01N33/6818 ,  C12N2310/16 ,  C12N2320/11

摘要： The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.