知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

40 records (took 0.059 seconds)

    USE OF APTAMERS IN PROTEOMICS
    1.
    发明申请
    USE OF APTAMERS IN PROTEOMICS 有权

    公开(公告)号：US20220002780A1

    公开(公告)日：2022-01-06

    申请号：US17222772

    申请日：2021-04-05

    Applicant: Caris Science, Inc.

    Inventor： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

    IPC: C12Q1/6804 ,  C12N15/11 ,  C12N15/115 ,  G01N33/68

    Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.

    Use of aptamers in proteomics
    5.
    发明授权
    Use of aptamers in proteomics 有权

    公开(公告)号：US10316349B2

    公开(公告)日：2019-06-11

    申请号：US15669782

    申请日：2017-08-04

    Applicant: Caris Science, Inc.

    Inventor： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

    IPC: C12N15/115 ,  C12Q1/68 ,  C12Q1/6804 ,  C12N15/11 ,  G01N33/68

    Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.

    BIOMARKER COMPOSITIONS AND METHODS
    7.
    发明申请
    BIOMARKER COMPOSITIONS AND METHODS 审中-公开
    生物标记物组合物和方法

    公开(公告)号：US20150301058A1

    公开(公告)日：2015-10-22

    申请号：US14646708

    申请日：2013-11-26

    Applicant: CARIS SCIENCE, INC.

    Inventor： Jorge Schettini ,  Tassilo Hornung ,  Daniel Holterman ,  David Spetzler

    IPC: G01N33/574 ,  A61K39/00 ,  C12Q1/68 ,  C12N15/115

    CPC classification number: G01N33/57488 ,  A61K39/0011 ,  A61K2039/6025 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/3513 ,  C12N2310/531 ,  C12N2320/10 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/5076 ,  G01N33/53

    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles, and nucleic acid-protein complexes. The invention provides methods of assessing microvesicles in a biological sample. The invention also provides an aptamer to a microvesicle surface antigen. The aptamer may be used for therapeutic purposes.

    Abstract translation: 可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展，选择疾病，病情，疾病阶段和疾病阶段的候选治疗方案 ，并确定治疗效果。 来自体液的循环生物标志物可用于生理状态的分析或确定表型。 这些包括核酸，蛋白质和循环结构如囊泡和核酸 - 蛋白质复合物。 本发明提供了评估生物样品中微泡的方法。 本发明还提供了微泡表面抗原的适体。 适体可用于治疗目的。

    Use of aptamers in proteomics
    10.
    发明授权
    Use of aptamers in proteomics 有权

    公开(公告)号：US11624083B2

    公开(公告)日：2023-04-11

    申请号：US17838984

    申请日：2022-06-13

    Applicant: Caris Science, Inc.

    Inventor： Clive Gavin Brown ,  Koen Kas ,  Sven Agnes Jan Eyckerman

    IPC: C12Q1/6804 ,  C12N15/11 ,  C12N15/115 ,  G01N33/68

    Abstract: The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated.

Patent Agency Ranking