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43 条记录 (耗时 0.04 秒)

    Resistive heaters and anisotropic thermal transfer
    4.
    发明授权
    Resistive heaters and anisotropic thermal transfer 有权

    公开(公告)号：US11786906B2

    公开(公告)日：2023-10-17

    申请号：US16093124

    申请日：2017-04-14

    申请人： BIOFIRE DEFENSE, LLC

    发明人： David E. Jones ,  Michael Bills ,  Aaron D. Wernerehl ,  Anson Cole Chamberlain

    IPC分类号： B01L7/00 ,  B01L3/00

    CPC分类号： B01L7/52 ,  B01L3/5027 ,  B01L2200/16 ,  B01L2300/1822 ,  B01L2300/1827

    摘要： System, heaters, and heat transfer devices are disclosed. For example, a system for performing polymerase chain reaction includes a support member configured to receive a sample vessel and a heater that is positioned to affect a temperature of the sample vessel. The system additionally includes a heat transfer device disposed between the heater and the sample vessel. The heat transfer device illustratively includes anisotropic fibers axially aligned parallel to one another and positioned to conduct heat from the at least one heater toward the sample vessel in the axial direction of the anisotropic fibers. An exemplary heater includes a body defining one or more channels, a heating element positioned in the one or more channels, and retention members adjacent the one or more channels. At least a portion of the heating element is mechanically interlocked with the channel by deforming the retention members into a closed position.

    Thermal cycler apparatus and related methods
    6.
    发明授权
    Thermal cycler apparatus and related methods 有权

    公开(公告)号：US11376599B2

    公开(公告)日：2022-07-05

    申请号：US15229046

    申请日：2016-08-04

    申请人： BioFire Defense, LLC

    发明人： Zackery Kent Evans ,  Thomas Knight Bodily ,  Richard David Abbott ,  Patrick L. Riley

    IPC分类号： B01L7/00

    摘要： An apparatus for thermal cycling can transfer heat uniformly and efficiently. The apparatus can be used in a method that reduces condensation on sample wells. The apparatus can also be manufactured to provide uniform configurations. For example, a sample illustratively for polymerase chain reaction (PCR), in each sample well and the components of the embodiment of the thermal cycler apparatus shown at including a well block, a base plate, a layer of adhesive, a peltier device, another layer of adhesive and a heat sink.

    Solid fluorescence standard
    8.
    发明授权
    Solid fluorescence standard 有权

    公开(公告)号：US11340169B2

    公开(公告)日：2022-05-24

    申请号：US16802319

    申请日：2020-02-26

    申请人： BioFire Defense, LLC

    发明人： Patrick L. Riley ,  Richard David Abbott ,  Lyle M. Nay ,  Sarah M. Fowden

    IPC分类号： G01N21/64 ,  B41M3/14 ,  G01N21/27 ,  B01L3/00 ,  B01L7/00

    摘要： A solid fluorescence standard that can be used to calibrate and/or normalize a device (e.g., a scientific instrument) that is configured for generating and collecting fluorescence data. A fluorescence standard disclosed herein includes an adhesive (e.g., a low viscosity, substantially optically transparent, solvent-free, radiation curable adhesive, such as, but not limited to, a UV curable adhesive), and a selected quantity of fluorescent particles (e.g., quantum dots) dispersed in the adhesive. The adhesive and the fluorescent particles are mixed together and disposed in a sample well. The adhesive is then cured and solidified, which yields a solid fluorescence standard in the well.