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公开(公告)号：US20120203174A1
公开(公告)日：2012-08-09
申请号：US13446761
申请日：2012-04-13
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
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公开(公告)号：US20100312327A1
公开(公告)日：2010-12-09
申请号：US12479440
申请日：2009-06-05
CPC分类号： A61L31/022 , C22C27/00
摘要： A medical device such as, for example, an implantable expandable stent is constructed of a ternary alloy of molybdenum, rhenium, and a third metal. In a preferred embodiment, the third metal is a refractory metal selected to improve the ductility of the alloy. The alloy may further be advantageously constructed to have a crystal structure selected from HCP, BCC, FCC, and tetragonal to further optimize the physical characteristics of the medical device.
摘要翻译： 诸如例如可植入式可扩张支架的医疗装置由钼，铼和第三金属的三元合金构成。 在优选实施例中，第三金属是选择用于改善合金的延展性的难熔金属。 该合金还可有利地构造成具有选自HCP，BCC，FCC和四方晶的晶体结构，以进一步优化医疗器件的物理特性。
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公开(公告)号：US20140081134A1
公开(公告)日：2014-03-20
申请号：US13843363
申请日：2013-03-15
发明人： Aaron M. Fortson , Marc Gianotti , David Milazzo
IPC分类号： A61M25/00
CPC分类号： A61M25/0026 , A61M25/003 , A61M25/007 , A61M25/09 , A61M31/005 , A61M2025/0039 , A61M2025/0076
摘要： A catheter comprising a first lumen for receiving a guidewire and having an exit opening at a distal tip of the catheter. A second lumen, adjacent the first lumen and separated from the first lumen by a common wall, the second lumen configured for receiving contrast fluid, wherein perforations are formed in the common wall; a guidewire in the first lumen the guidewire being configured to be capable of advancement distally to extend out of the exit opening, the guidewire having two conditions: a first condition in which the guidewire is advanced distally to block the perforations whereby fluid may not flow from the second lumen to the first lumen; a second condition in which the guidewire is withdrawn proximally to unblock the perforations whereby fluid may flow from the second lumen into the first lumen and thence out of the exit opening.
摘要翻译： 导管，其包括用于接收导丝并且在导管的远端处具有出口的第一腔。 第二腔，与第一腔相邻并且与第一腔相隔一个共同的壁，第二腔构造成用于接收对比液，其中在公共壁中形成穿孔; 所述导丝在所述第一管腔中被配置为能够向远侧前进以延伸出所述出口，所述导丝具有两个条件：第一状态，其中所述导丝向远侧推进以阻挡所述穿孔，从而流体不能从 第二个管腔到第一个管腔; 第二条件是其中向导引线被近端地撤回以打开穿孔，由此流体可以从第二腔流入第一管腔并且从那里流出出口。
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4.发明授权公开(公告)号：US08435550B2
公开(公告)日：2013-05-07
申请号：US12191209
申请日：2008-08-13
申请人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F. A. Hossainy
发明人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F. A. Hossainy
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61K31/4745 , A61K31/56 , A61K31/573 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
摘要翻译： 提供了一种药物递送系统，其包括至少100杯依维莫司和氯倍他索，使得依维莫司与氯倍他索的比例至少为10：1（w / w），依维莫司的重量比为至少10倍 氯倍他索 该系统可以是支架。 还提供了治疗血管的再狭窄或易损斑块的方法，所述方法包括向患者局部施用选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司， 40-（2-羟基）乙基雷帕霉素（依维莫司），40-O-（3-羟基）丙基雷帕霉素，40-O- [2-（2-羟基）乙氧基]乙基雷帕霉素，40- O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且对患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100杯，其中 第二种药物的第一种药物例如为10：1〜100：1（w / w）。
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公开(公告)号：US20140272873A1
公开(公告)日：2014-09-18
申请号：US13840406
申请日：2013-03-15
IPC分类号： G09B23/34
CPC分类号： G09B23/34
摘要： A teaching aid has visual indicia thereon simulating the circulatory system of an organism. The teaching aid includes (i) a template having visual indicia thereon simulating the circulatory system of an organism; and (ii) a plurality of connectors for connecting a medical device to the template. The template comprises (a) a base, and (b) visual indicia on the base, simulating the circulatory system of an organism.
摘要翻译： 教学用具有可视标记，用于模拟生物体的循环系统。 该教具包括（i）模板，其上具有模拟生物循环系统的视觉标记; 和（ii）用于将医疗装置连接到模板的多个连接器。 模板包括（a）基底，和（b）基部上的视觉标记，模拟生物体的循环系统。
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公开(公告)号：US20160324669A1
公开(公告)日：2016-11-10
申请号：US14703697
申请日：2015-05-04
发明人： Tram U. Le , Justin Mann
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9517 , A61F2240/002 , A61M25/0009 , A61M25/0021 , A61M25/0023 , A61M25/0026 , A61M25/0045 , A61M2025/0035 , A61M2025/0037
摘要： A system for providing a continuous passage through a delivery catheter comprising a handle that defines an internal chamber. A first tube having a proximal end and a distal end and a first bore, the first tube being fixedly mounted within the handle, wherein the first bore at the distal end of the first tube is shaped to define a first inverse conical surface. A second tube having a proximal end and a distal end and a second bore, the second tube being slidably mounted within the handle, wherein the second bore is in axial alignment with the first bore. A third tube having a proximal end and a distal end and a third bore.
摘要翻译： 一种用于提供通过输送导管的连续通道的系统，包括限定内部腔室的把手。 具有近端和远端的第一管和第一孔，第一管固定地安装在手柄内，其中第一管的远端处的第一孔成形为限定第一倒锥形表面。 具有近端和远端的第二管和第二孔，所述第二管可滑动地安装在所述手柄内，其中所述第二孔与所述第一孔轴向对准。 具有近端和远端的第三管和第三孔。
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公开(公告)号：US09821091B2
公开(公告)日：2017-11-21
申请号：US13953656
申请日：2013-07-29
发明人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC分类号： A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
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公开(公告)号：US20130165903A1
公开(公告)日：2013-06-27
申请号：US13776579
申请日：2013-02-25
CPC分类号： A61B17/12022 , A61B17/1204 , A61M25/0021 , A61M25/1002 , A61M25/10182 , A61M25/10188 , A61M25/1027 , A61M2025/1052
摘要： A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume.
摘要翻译： 一种受控体积的充气 - 放气装置，用于通过拨打锁定在旋转位置处的手柄来使气囊膨胀以封闭血管，以将柱塞定位在充气 - 放气装置的注射器内的等间隔位置处。 充气 - 放气装置包括可释放的闩锁，以将近端和远端壳体锁定在一起以将柱塞保持在前方用于闭塞，并且分离并保持近端和远端壳体以缩回柱塞用于灌注。 当充气 - 放气装置返回到锁定位置时，将气囊重新膨胀至其先前的闭塞直径。 此外，可以使用由较高模量的内部材料共挤出并可与较高模量的内部材料混合的由较低模量的外部材料制成的延伸管，以产生用于充气 - 收缩装置的合适的柔顺性延伸管。 气球可以具有锥形端部和圆柱形中心部分，使得响应于增加的充气体积的相等增加，其在外径中增加更多相等的增量。
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公开(公告)号：US08382819B2
公开(公告)日：2013-02-26
申请号：US12685991
申请日：2010-01-12
申请人： Brian Lee Pelton , John F. Boylan
发明人： Brian Lee Pelton , John F. Boylan
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/962 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2210/0019 , A61F2230/0013 , A61L31/022 , A61L31/14 , A61L31/18 , A61L2400/16 , C22C19/03 , C22F1/006 , Y10S623/90 , Y10S623/901
摘要： A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.
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