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    Methods for the detection of cervical cancer
    1.
    发明授权
    Methods for the detection of cervical cancer 失效
    检测宫颈癌的方法

    公开(公告)号：US6027905A

    公开(公告)日：2000-02-22

    申请号：US989045

    申请日：1997-12-11

    申请人： Susan K. Keesee ,  Robert Obar ,  Ying-Jye Wu

    发明人： Susan K. Keesee ,  Robert Obar ,  Ying-Jye Wu

    IPC分类号： A61K31/7088 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P15/00 ,  A61P35/00 ,  C07K16/32 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  C07K16/30

    CPC分类号： G01N33/6848 ,  G01N33/57411 ,  G01N33/57496 ,  G01N33/68 ,  G01N33/6851 ,  G01N2800/52

    摘要： The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.

    摘要翻译： 本发明提供广泛的用于检测和治疗个体宫颈癌的方法和组合物。 具体地，本发明提供了靶向宫颈癌相关蛋白，其允许宫颈癌的快速检测，优选在转移之前发生。 目标宫颈癌相关蛋白可以例如通过使样品与标记的结合部分反应来检测，例如，能够特异性结合蛋白质的标记抗体。 本发明还提供了可用于检测个体中子宫颈癌的试剂盒。 此外，本发明提供了利用宫颈癌相关蛋白作为治疗子宫颈癌的靶标或用于监测这种治疗功效的指标的方法。

    Methods and compositions for the detection of colon cancers
    2.
    发明授权
    Methods and compositions for the detection of colon cancers 失效
    用于检测结肠癌的方法和组合物

    公开(公告)号：US5547928A

    公开(公告)日：1996-08-20

    申请号：US168993

    申请日：1993-12-17

    申请人： Ying-Jye Wu ,  Susan K. Keesee

    发明人： Ying-Jye Wu ,  Susan K. Keesee

    IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  G01N33/68 ,  A61K38/17 ,  A61K35/38 ,  C07K1/28 ,  C07K14/435

    CPC分类号： C07K14/47 ,  C07K16/3046 ,  G01N33/57419 ,  G01N33/57446 ,  G01N33/6893 ,  Y10S436/813 ,  Y10S530/828 ,  Y10S530/844

    摘要： The invention provides methods and compositions for identifying colon cancers in an individual. In one embodiment of the invention, a colon adenocarcinoma-associated protein may be detected in a tissue or body fluid sample of an individual, to provide an indication of the presence of an adenocarcinoma of the colon in the individual. The target adenocarcinoma-associated protein, may be detected, e.g., by reacting the sample with a labeled binding moiety, such as a labeled antibody, capable of specifically binding the protein. In another embodiment, the protein may be detected by isolating one or more colon adenocarcinoma-associated proteins from the sample, separating the proteins by two dimensional gel electrophoresis, and comparing the gel electrophoresis pattern with a standard. The invention provides a wide range of assay methods and compositions which may be used for detecting colon tumors in an individual rapidly and reproducibly, optimally at early stages of the disease.

    摘要翻译： 本发明提供用于鉴定个体中结肠癌的方法和组合物。 在本发明的一个实施方案中，可以在个体的组织或体液样品中检测结肠腺癌相关蛋白，以提供个体中结肠腺癌的存在的指示。 目标腺癌相关蛋白可以例如通过使样品与能够特异性结合蛋白质的标记结合部分，例如标记的抗体反应来检测。 在另一个实施方案中，可以通过从样品中分离一种或多种结肠腺癌相关蛋白来检测蛋白质，通过二维凝胶电泳分离蛋白质，并将凝胶电泳图谱与标准物进行比较。 本发明提供了广泛的测定方法和组合物，其可用于在疾病的早期阶段快速且可重复地，最佳地检测个体中的结肠肿瘤。

    Methods and compositions for the detection of colon cancers
    3.
    发明授权
    Methods and compositions for the detection of colon cancers 失效

    公开(公告)号：US5830677A

    公开(公告)日：1998-11-03

    申请号：US448048

    申请日：1995-05-23

    申请人： Ying-Jye Wu ,  Susan K. Keesee

    发明人： Ying-Jye Wu ,  Susan K. Keesee

    IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  G01N33/68 ,  G01N33/53

    CPC分类号： C07K14/47 ,  C07K16/3046 ,  G01N33/57419 ,  G01N33/57446 ,  G01N33/6893 ,  Y10S436/813 ,  Y10S530/828 ,  Y10S530/844

    摘要： The invention provides methods and compositions for identifying colon cancers in an individual. In one embodiment of the invention, a colon adenocarcinoma-associated protein may be detected in a tissue or body fluid sample of an individual, to provide an indication of the presence of an adenocarcinoma of the colon in the individual. The target adenocarcinoma-associated protein, may be detected, e.g., by reacting the sample with a labeled binding moiety, such as a labeled antibody, capable of specifically binding the protein. In another embodiment, the protein may be detected by isolating one or more colon adenocarcinoma-associated proteins from the sample, separating the proteins by two dimensional gel electrophoresis, and comparing the gel electrophoresis pattern with a standard. The invention provides a wide range of assay methods and compositions which may be used for detecting colon tumors in an individual rapidly and reproducibly, optimally at early stages of the disease.

    Methods for the detection of cervical cancer
    4.
    发明授权
    Methods for the detection of cervical cancer 失效
    检测宫颈癌的方法

    公开(公告)号：US06803189B2

    公开(公告)日：2004-10-12

    申请号：US09315355

    申请日：1999-05-17

    申请人： Susan K. Keesee ,  Robert Obar ,  Ying-Jye Wu

    发明人： Susan K. Keesee ,  Robert Obar ,  Ying-Jye Wu

    IPC分类号： C12Q168

    CPC分类号： G01N33/6848 ,  G01N33/57411 ,  G01N33/57496 ,  G01N33/68 ,  G01N33/6851 ,  G01N2800/52

    摘要： The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.

    摘要翻译： 本发明提供广泛的用于检测和治疗个体宫颈癌的方法和组合物。 具体地，本发明提供了靶向宫颈癌相关蛋白，其允许宫颈癌的快速检测，优选在转移之前发生。 目标宫颈癌相关蛋白可以例如通过使样品与标记的结合部分反应来检测，例如，能够特异性结合蛋白质的标记抗体。 本发明还提供了可用于检测个体中子宫颈癌的试剂盒。 此外，本发明提供了利用宫颈癌相关蛋白作为治疗子宫颈癌的靶标或用于监测这种治疗功效的指标的方法。

    Methods and compositions for the detection of cervical cancer
    7.
    发明授权
    Methods and compositions for the detection of cervical cancer 失效
    检测宫颈癌的方法和组成

    公开(公告)号：US5858683A

    公开(公告)日：1999-01-12

    申请号：US705660

    申请日：1996-08-30

    申请人： Susan K. Keesee ,  Robert Obar ,  Ying-Jye Wu

    发明人： Susan K. Keesee ,  Robert Obar ,  Ying-Jye Wu

    IPC分类号： A61K31/7088 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P15/00 ,  A61P35/00 ,  C07K16/32 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  G01N33/53

    CPC分类号： G01N33/6848 ,  G01N33/57411 ,  G01N33/57496 ,  G01N33/68 ,  G01N33/6851 ,  G01N2800/52

    摘要： The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.

    摘要翻译： 本发明提供广泛的用于检测和治疗个体宫颈癌的方法和组合物。 具体地，本发明提供了靶向宫颈癌相关蛋白，其允许宫颈癌的快速检测，优选在转移之前发生。 目标宫颈癌相关蛋白可以例如通过使样品与标记的结合部分反应来检测，例如，能够特异性结合蛋白质的标记抗体。 本发明还提供了可用于检测个体中子宫颈癌的试剂盒。 此外，本发明提供了利用宫颈癌相关蛋白作为治疗子宫颈癌的靶标或用于监测这种治疗功效的指标的方法。