知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

60 条记录 (耗时 0.047 秒)

    Inhibition of ornithine aminotransferase for the treatment of proliferative disorders
    1.
    发明授权
    Inhibition of ornithine aminotransferase for the treatment of proliferative disorders 有权
    抑制鸟氨酸氨基转移酶治疗增殖性疾病

    公开(公告)号：US08686041B2

    公开(公告)日：2014-04-01

    申请号：US13484392

    申请日：2012-05-31

    申请人： Yaron Ilan ,  Ehud Zigmond ,  Richard B. Silverman ,  Hejun Lu

    发明人： Yaron Ilan ,  Ehud Zigmond ,  Richard B. Silverman ,  Hejun Lu

    IPC分类号： A01N37/08 ,  A01N53/00 ,  A61K31/19 ,  A61K31/557

    CPC分类号： A61K31/196 ,  A61K31/198

    摘要： The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.

    摘要翻译： 本发明涉及抑制鸟氨酸氨基转移酶（OAT）抑制肿瘤细胞增殖。 更具体地说，本发明涉及通过选择性抑制OAT来治疗增殖性疾病的方法，并进一步提供使用OAT抑制剂，特别是5-氨基-1,3-己二烯基羧酸（Gabaculine）和加珠菌素类似物 8，用于治疗增殖性疾病如肝细胞癌的组合物和方法。 本发明还基于确定从受试者获得的生物样品中表达的OAT水平，提供用于诊断哺乳动物受试者中病理性增殖性病症的方法和试剂盒。

    Inhibition of ornithine aminotransferase for the treatment of proliferative disorders
    2.
    发明授权
    Inhibition of ornithine aminotransferase for the treatment of proliferative disorders 有权
    抑制鸟氨酸氨基转移酶治疗增殖性疾病

    公开(公告)号：US08211865B2

    公开(公告)日：2012-07-03

    申请号：US12377889

    申请日：2007-08-20

    申请人： Yaron Ilan ,  Ehud Zigmond ,  Richard B. Silverman ,  Hejun Lu

    发明人： Yaron Ilan ,  Ehud Zigmond ,  Richard B. Silverman ,  Hejun Lu

    IPC分类号： A61K48/00

    CPC分类号： A61K31/196 ,  A61K31/198

    摘要： The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.

    摘要翻译： 本发明涉及抑制鸟氨酸氨基转移酶（OAT）抑制肿瘤细胞增殖。 更具体地说，本发明涉及通过选择性抑制OAT来治疗增殖性疾病的方法，并进一步提供使用OAT抑制剂，特别是5-氨基-1,3-己二烯基羧酸（Gabaculine）和加珠菌素类似物 8，用于治疗增殖性疾病如肝细胞癌的组合物和方法。 本发明还基于确定从受试者获得的生物样品中表达的OAT水平，提供用于诊断哺乳动物受试者中病理性增殖性病症的方法和试剂盒。

    INHIBITION OF ORNITHINE AMINOTRANSFERASE FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
    3.
    发明申请
    INHIBITION OF ORNITHINE AMINOTRANSFERASE FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 有权
    用于治疗增殖性疾病的异丙酰氨基转移酶的抑制

    公开(公告)号：US20100016412A1

    公开(公告)日：2010-01-21

    申请号：US12377889

    申请日：2007-08-20

    申请人： Yaron Ilan ,  Ehud Zigmond

    发明人： Yaron Ilan ,  Ehud Zigmond

    IPC分类号： A61K31/7088 ,  A61K31/195 ,  C12Q1/68

    CPC分类号： A61K31/196 ,  A61K31/198

    摘要： The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.

    摘要翻译： 本发明涉及抑制鸟氨酸氨基转移酶（OAT）抑制肿瘤细胞增殖。 更具体地说，本发明涉及通过选择性抑制OAT来治疗增殖性疾病的方法，并进一步提供使用OAT抑制剂，特别是5-氨基-1,3-己二烯基羧酸（Gabaculine）和加珠菌素类似物 8，用于治疗增殖性疾病如肝细胞癌的组合物和方法。 本发明还基于确定从受试者获得的生物样品中表达的OAT水平，提供用于诊断哺乳动物受试者中病理性增殖性病症的方法和试剂盒。

    METHOD AND SYSTEM FOR DETECTION OF PRE-FAINTING AND OTHER CONDITIONS HAZARDOUS TO THE HEALTH OF A PATIENT
    6.
    发明申请
    METHOD AND SYSTEM FOR DETECTION OF PRE-FAINTING AND OTHER CONDITIONS HAZARDOUS TO THE HEALTH OF A PATIENT 审中-公开
    检测预防和危及患者健康的其他条件的方法和系统

    公开(公告)号：US20100268040A1

    公开(公告)日：2010-10-21

    申请号：US12747418

    申请日：2008-12-10

    申请人： Ilan Ben-Oren ,  Yaron Ilan

    发明人： Ilan Ben-Oren ,  Yaron Ilan

    IPC分类号： A61B5/00

    CPC分类号： A61B5/024 ,  A61B5/01 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0402 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4094 ,  A61B5/4261 ,  A61B5/4839 ,  A61B5/7275 ,  G16H40/63 ,  G16H50/20 ,  G16H50/50

    摘要： Included herein are embodiments relating to detecting and warning of the presence of pre-fainting and other conditions that may be hazardous to the health of a patient having one or more types of disease or disorder. A wide range of physiological and physical parameters can be monitored and logically and/or mathematically related to determine the value of a new parameter, the risk parameter alpha. The parameters that appear in the function can be selected according to the patient's known pathological condition. An initial threshold value for alpha can be determined and compared with a current value of alpha. If the comparison shows that there exists danger of the onset of a pre-fainting and/or other medically hazardous condition, a warning signal can be emitted. The current value of alpha can be continually determined and, if relevant, updated according to the history of the patient.

    摘要翻译： 本文包括涉及检测和警告可能对具有一种或多种类型的疾病或病症的患者的健康有害的预晕影和其它状况的警告。 可以监测各种生理和物理参数，并在逻辑上和/或数学上相关，以确定新参数的值，风险参数α。 功能中出现的参数可以根据患者的已知病理状况进行选择。 可以确定α的初始阈值并将其与当前的α值进行比较。 如果比较表明存在发生预晕和/或其他医疗危险状况的危险，则可以发出警告信号。 α的当前值可以不断地确定，如果相关，则根据患者的病史进行更新。

    Breath Test Device and Method
    7.
    发明申请
    Breath Test Device and Method 有权
    呼吸试验装置及方法

    公开(公告)号：US20100036273A1

    公开(公告)日：2010-02-11

    申请号：US12084629

    申请日：2006-11-12

    申请人： Ilan Ben-Oren ,  Avarham Hershkowitz ,  Eli Kaplan ,  Yaron Ilan

    发明人： Ilan Ben-Oren ,  Avarham Hershkowitz ,  Eli Kaplan ,  Yaron Ilan

    IPC分类号： A61B5/08

    CPC分类号： A61K51/04 ,  A61K51/0402 ,  A61K51/1206 ,  A61K51/1268 ,  B82Y5/00 ,  G06F19/00

    摘要： The disclosure relates breath test devices and methods for the evaluation of liver functional and metabolic capacity or to assess liver heath and/or degree of liver injury. Specifically, there is provided a method of evaluating a liver condition, the method includes on-line monitoring a metabolic product of methacetin, a salt or a derivative of methacetin, in a subject's breath after administering to the subject isotope labeled methacetin, a salt or a derivative thereof in water solution form. There is also provided a device for evaluating a liver condition, the device includes one or more sensors adapted to monitor on-line an isotope level of a metabolic product of labeled methacetin, or a salt or a derivative of methacetin in a subject's breath and a controller adapted to sample measurements of the one or more sensors at a continuous mode.

    摘要翻译： 本公开涉及用于评估肝功能和代谢能力的呼吸测试装置和方法，或评估肝脏健康和/或肝损伤程度。 具体地，提供了一种评估肝脏状况的方法，该方法包括在对受试者同位素标记的美沙西丁施用之后，在受试者的呼吸中在线监测美沙西丁，美沙西丁的盐或衍生物的代谢产物，盐或 其衍生物为水溶液形式。 还提供了一种用于评估肝脏状况的装置，该装置包括一个或多个传感器，适用于在线监测标记的美沙西丁的代谢产物的同位素水平，或受试者呼吸中的美沙西丁的盐或衍生物， 控制器适于在连续模式下采样所述一个或多个传感器的测量。

    Processes for treating subjects carrying viral infectious agent
    8.
    发明申请
    Processes for treating subjects carrying viral infectious agent 审中-公开
    用于治疗携带病毒感染因子的受试者的方法

    公开(公告)号：US20100021500A1

    公开(公告)日：2010-01-28

    申请号：US12583271

    申请日：2009-08-18

    申请人： Yaron Ilan ,  Elazar Rabbani ,  Dean L. Engelhardt ,  Israel Gotsman ,  James J. Donegan

    发明人： Yaron Ilan ,  Elazar Rabbani ,  Dean L. Engelhardt ,  Israel Gotsman ,  James J. Donegan

    IPC分类号： A61K39/29 ,  A61K39/00 ,  A61P37/04

    CPC分类号： A61K39/0005 ,  A61K38/00 ,  A61K39/001 ,  A61K39/12 ,  A61K39/292 ,  A61K2035/122 ,  A61K2039/5152 ,  A61K2039/542 ,  A61K2039/57 ,  C12N2730/10134

    摘要： This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.

    摘要翻译： 本发明提供了用于治疗应用的新方法，包括治疗携带感染性物质或具有受损的自身免疫或免疫病症受损的受试者。 本文公开的治疗应用还涉及用含有癌细胞或恶性或癌细胞的恶性肿瘤治疗癌性受试者。 还提供了预防受试者感染的疫苗接种过程。 该新颖方法包括向受试者引入或施用一种或多种抗原或训练或采用的免疫细胞。 这些抗原或免疫细胞能够建立或增加至少一种第一特异性免疫应答并减少至少一种第二特异性免疫应答。 这些反应包括组分，如细胞免疫反应元件，体液免疫反应元件和细胞因子，后者还包括干扰素和淋巴因子。 本发明也提供有用的组合物。

    Novel therapeutic processes for establishing or enhancing an immunized state, and compositions useful therefor
    10.
    发明申请
    Novel therapeutic processes for establishing or enhancing an immunized state, and compositions useful therefor 审中-公开
    用于建立或增强免疫状态的新型治疗方法及其有用的组合物

    公开(公告)号：US20050118196A1

    公开(公告)日：2005-06-02

    申请号：US10470599

    申请日：2003-12-08

    申请人： Yaron Ilan ,  Elazar Rabbani ,  Dean Engelhardt ,  Israel Gotsman ,  James Donegan

    发明人： Yaron Ilan ,  Elazar Rabbani ,  Dean Engelhardt ,  Israel Gotsman ,  James Donegan

    IPC分类号： A61K35/12 ,  A61K38/095 ,  A61K39/00 ,  A61K39/21 ,  A61K39/29 ,  A61P31/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P37/04 ,  A61K39/12 ,  A61K39/02

    CPC分类号： A61K39/0005 ,  A61K38/00 ,  A61K39/001 ,  A61K39/12 ,  A61K39/292 ,  A61K2035/122 ,  A61K2039/5152 ,  A61K2039/542 ,  A61K2039/57 ,  C12N2730/10134

    摘要： This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.

    摘要翻译： 本发明提供了用于治疗应用的新方法，包括治疗携带感染性物质或具有受损的自身免疫或免疫病症受损的受试者。 本文公开的治疗应用还涉及用含有癌细胞或恶性或癌细胞的恶性肿瘤治疗癌性受试者。 还提供了预防受试者感染的疫苗接种过程。 该新颖方法包括向受试者引入或施用一种或多种抗原或训练或采用的免疫细胞。 这些抗原或免疫细胞能够建立或增加至少一种第一特异性免疫应答并减少至少一种第二特异性免疫应答。 这些反应包括组分，如细胞免疫反应元件，体液免疫反应元件和细胞因子，后者还包括干扰素和淋巴因子。 本发明也提供有用的组合物。