公开(公告)号：US20100036273A1

公开(公告)日：2010-02-11

申请号：US12084629

申请日：2006-11-12

申请人： Ilan Ben-Oren ,  Avarham Hershkowitz ,  Eli Kaplan ,  Yaron Ilan

发明人： Ilan Ben-Oren ,  Avarham Hershkowitz ,  Eli Kaplan ,  Yaron Ilan

IPC分类号： A61B5/08

CPC分类号： A61K51/04 ,  A61K51/0402 ,  A61K51/1206 ,  A61K51/1268 ,  B82Y5/00 ,  G06F19/00

摘要： The disclosure relates breath test devices and methods for the evaluation of liver functional and metabolic capacity or to assess liver heath and/or degree of liver injury. Specifically, there is provided a method of evaluating a liver condition, the method includes on-line monitoring a metabolic product of methacetin, a salt or a derivative of methacetin, in a subject's breath after administering to the subject isotope labeled methacetin, a salt or a derivative thereof in water solution form. There is also provided a device for evaluating a liver condition, the device includes one or more sensors adapted to monitor on-line an isotope level of a metabolic product of labeled methacetin, or a salt or a derivative of methacetin in a subject's breath and a controller adapted to sample measurements of the one or more sensors at a continuous mode.

摘要翻译： 本公开涉及用于评估肝功能和代谢能力的呼吸测试装置和方法，或评估肝脏健康和/或肝损伤程度。 具体地，提供了一种评估肝脏状况的方法，该方法包括在对受试者同位素标记的美沙西丁施用之后，在受试者的呼吸中在线监测美沙西丁，美沙西丁的盐或衍生物的代谢产物，盐或 其衍生物为水溶液形式。 还提供了一种用于评估肝脏状况的装置，该装置包括一个或多个传感器，适用于在线监测标记的美沙西丁的代谢产物的同位素水平，或受试者呼吸中的美沙西丁的盐或衍生物， 控制器适于在连续模式下采样所述一个或多个传感器的测量。