公开(公告)号：US20030186454A1

公开(公告)日：2003-10-02

申请号：US10303446

申请日：2002-11-22

Applicant: Xerox Corporation

Inventor： Richard H. Bruce ,  Steven Rosenberg

IPC: G01N025/20

CPC classification number: B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A method is disclosed for performing drug lead profiling assays for drug discovery utilizing a nanocalorimeter. The method includes depositing not less than one drop containing a profile molecule solution to be screened and not less than one drop containing a drug library compound on a test substrate. After the drops are merged, a determination is made as to whether a reaction has occurred.

Abstract translation: 公开了一种利用纳米光度计进行药物发现的药物铅分析测定的方法。 该方法包括将不少于一滴含有待筛选的分布分析溶液和不少于一滴含有药物文库化合物的滴在沉积物上的沉积物。 液滴合并后，确定是否发生反应。

公开(公告)号：US20020102555A1

公开(公告)日：2002-08-01

申请号：US09773804

申请日：2001-02-01

Applicant: XEROX CORPORATION

Inventor： Richard H. Bruce ,  Scott A. Elrod ,  Babur B. Hadimioglu ,  David A. Horine ,  Jaan Noolandi ,  Joy Roy ,  Robert A. Sprague

IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  B05D003/00

CPC classification number: G01N35/10 ,  G01N35/00712 ,  G01N35/1009 ,  G01N2035/1037 ,  G06F19/00

Abstract: A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

Abstract translation: 提供了一种用于确保印刷生物测定中的质量控制的方法和机制。 具有多个单独的液滴喷射器的多喷射器系统装载有各种生物流体。 生物流体至少包括载体流体，用于测试的生物材料和标记物，例如荧光染料。 关于装载在每个液滴喷射器中的生物流体的数据与生物流体的预期签名输出一起存储。 特别地，签名输出表示来自生物流体内包含的荧光标记的各个信号。 一旦已经印刷了由生物流体液滴组成的生物测定法，能够检测标记物的扫描仪扫描生物测定并获得生物测定中每一滴的签名输出信号。 进行比较操作以将获得的通过扫描操作的签名输出与加载在相应的滴液喷射器中的生物流体的预期签名输出信号进行比较。 生物材料本身也可以用标记来标记，以确保其包含在生物流体中。 通过比较操作，可以验证生物流体是否装载在适当的滴液喷射器中，包括适当的生物材料，并且液滴喷射器正常工作。

公开(公告)号：US20040071332A1

公开(公告)日：2004-04-15

申请号：US10616366

申请日：2003-07-09

Applicant: XEROX CORPORATION

Inventor： Richard H. Bruce ,  Douglas N. Curry ,  Robert T. Krivacic ,  Huangpin B. Hsieh

IPC: G06K009/00

CPC classification number: B82Y20/00 ,  B82Y5/00 ,  B82Y10/00 ,  G01N15/1468 ,  G01N2015/0065

Abstract: In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.

Abstract translation: 根据本申请的一个方面，公开了一种用于检测和定位样品中的稀有细胞的成像器和方法。 成像器台支持样品。 光纤束具有布置成限定观察平移台上的样品的输入孔的第一光纤端的近端束端。 光纤束还具有设置成限定与输入孔不同的形状的输出孔并远离成像器台设置的第二纤维端的远端束端。 扫描辐射源被布置在与输入孔相对的固定相对位置。 扫描辐射源在输入孔的观察区域内扫描样品上的辐射束。 辐射束与样品相互作用以产生被信号反射，散射，透射，再发射或以其它方式收集和接收的光信号，并通过光纤束传输到输出孔。 扫描辐射源将辐射束照射在样品的选定区域上。 光检测器被设置为检测远端束端处的光信号，并且处理器处理检测到的光信号。

公开(公告)号：US20030186455A1

公开(公告)日：2003-10-02

申请号：US10303500

申请日：2002-11-22

Applicant: Xerox Corporation

Inventor： Richard H. Bruce ,  Steven Rosenberg

IPC: G01N025/20

CPC classification number: B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A method is provided for multiple target screening for drug assays utilizing a nanocalorimeter. The method includes depositing a drop containing a plurality of drug targets and another drop containing a plurality of drug candidates upon a test substrate. The drops are merged and a determination is made as to whether a reaction has occurred between the drops. If such a reaction has occurred, the reacting drug targets and drug candidates are tested individually.

Abstract translation: 提供了一种利用纳米光度计进行药物测定的多目标筛选方法。 该方法包括在测试基底上沉积含有多个药物靶的液滴和含有多种药物候选物的另一液滴。 合并液滴，确定液滴之间是否发生反应。 如果发生这种反应，则单独测试反应药物靶标和药物候选物质。

公开(公告)号：US20030186453A1

公开(公告)日：2003-10-02

申请号：US10114611

申请日：2002-04-01

Applicant: Xerox Corporation

Inventor： Alan G. Bell ,  Richard H. Bruce ,  Scott A. Elrod ,  Eric Peeters ,  Francisco E. Torres

IPC: G01N025/20

CPC classification number: B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A nanocalorimeter array for detecting chemical reactions includes at least one thermal isolation region residing on a substrate. Each thermal isolation region includes at least one thermal equilibration region, within which resides a thermal measurement device connected to detection electronics.

Abstract translation: 用于检测化学反应的纳米尺度计阵列包括驻留在基底上的至少一个热隔离区域。 每个热隔离区域包括至少一个热平衡区域，其中存在连接到检测电子器件的热测量装置。