公开(公告)号：US20020073989A1

公开(公告)日：2002-06-20

申请号：US09739988

申请日：2000-12-18

Applicant: Xerox Corporation

Inventor： Babur B. Hadimioglu

IPC: A61M011/00 ,  B05B017/06

CPC classification number: B05B17/0615 ,  A61M11/005 ,  A61M15/0085 ,  A61M15/025

Abstract: An inhaler that uses capillary effects to output droplets of pharmaceutical product is described. The inhaler includes transducers and lenses to generate focused acoustic waves. The frequency and pulse width output of the transducers are set to cause capillary action in a reservoir of pharmaceutical product. The capillary action results in the ejection of small droplets of pharmaceutical product at low frequencies.

Abstract translation: 描述了使用毛细管效应输出药物液滴的吸入器。 吸入器包括用于产生聚焦声波的换能器和透镜。 换能器的频率和脉冲宽度输出被设置为在药品的储存器中引起毛细管作用。 毛细作用导致药物产品在低频下的喷射。

公开(公告)号：US20020102555A1

公开(公告)日：2002-08-01

申请号：US09773804

申请日：2001-02-01

Applicant: XEROX CORPORATION

Inventor： Richard H. Bruce ,  Scott A. Elrod ,  Babur B. Hadimioglu ,  David A. Horine ,  Jaan Noolandi ,  Joy Roy ,  Robert A. Sprague

IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  B05D003/00

CPC classification number: G01N35/10 ,  G01N35/00712 ,  G01N35/1009 ,  G01N2035/1037 ,  G06F19/00

Abstract: A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

Abstract translation: 提供了一种用于确保印刷生物测定中的质量控制的方法和机制。 具有多个单独的液滴喷射器的多喷射器系统装载有各种生物流体。 生物流体至少包括载体流体，用于测试的生物材料和标记物，例如荧光染料。 关于装载在每个液滴喷射器中的生物流体的数据与生物流体的预期签名输出一起存储。 特别地，签名输出表示来自生物流体内包含的荧光标记的各个信号。 一旦已经印刷了由生物流体液滴组成的生物测定法，能够检测标记物的扫描仪扫描生物测定并获得生物测定中每一滴的签名输出信号。 进行比较操作以将获得的通过扫描操作的签名输出与加载在相应的滴液喷射器中的生物流体的预期签名输出信号进行比较。 生物材料本身也可以用标记来标记，以确保其包含在生物流体中。 通过比较操作，可以验证生物流体是否装载在适当的滴液喷射器中，包括适当的生物材料，并且液滴喷射器正常工作。

公开(公告)号：US20020077369A1

公开(公告)日：2002-06-20

申请号：US09739989

申请日：2000-12-18

Applicant: Xerox Corporation

Inventor： Jaan Noolandi ,  Babur B. Hadimioglu ,  Robert A. Sprague

IPC: A61M011/00 ,  B05B017/06 ,  A62B007/00 ,  A62B009/00 ,  A61M015/00 ,  A61M016/00 ,  A62B018/00 ,  A61M016/10 ,  A01N025/00

CPC classification number: B05B17/0615 ,  A61M15/0085 ,  A61M15/025 ,  Y10S101/34

Abstract: An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.

Abstract translation: 描述了用于将药物递送至肺部的改进方法和装置。 声学油墨印刷技术被修改为作为在患者的鼻子或嘴部附近产生微小液滴的吸入器。 微小的液滴容易被气流携带到病人的肺部。 吸入器本身优选地是电池操作的便携式装置，其可以容易地携带并且容易地清洁以避免污染药物。

公开(公告)号：US20030052931A1

公开(公告)日：2003-03-20

申请号：US09954308

申请日：2001-09-12

Applicant: XEROX CORPORATION

Inventor： Babur B. Hadimioglu ,  Richard N. Ellson

IPC: B41J029/38

CPC classification number: B41J2/2139 ,  B41J2/0451 ,  B41J2/04525 ,  B41J2/04575 ,  B41J2/04595

Abstract: An at least two-pass acoustic printing system uses an acoustic printhead having an array of ejectors arranged in rows and columns. Operation of each ejector is individually controllable. To minimize cross-talk errors a first selected ejector in a selected row is identified as an odd ejector of the selected row. Thereafter a first firing sequence of the first selected ejector is generated based on the first selected ejector being identified as odd. Then a second ejector, immediately adjacent the first ejector, is selected and is identified as an even ejector. Thereafter a second firing sequence is generated for the second selected ejector based on the selector being identified as even. The first and second firing sequences result in the first ejector and the second ejector being active during non-concurrent time periods. When a defective ejector of the array is detected, an operable ejector firing to the same substrate area is determined. A firing sequence from or associated with the defective ejector is transferred to be used by the operable ejector wherein the operable ejector fires both its own firing sequence and the firing sequence of the defective ejector.

Abstract translation: 至少两声道声音打印系统使用具有排列成行和列的排列阵列的声学打印头。 每个喷射器的操作是可以单独控制的。 为了最小化串扰错误，所选行中的第一选择的喷射器被识别为所选行的奇数喷射器。 此后，基于第一选择的喷射器被识别为奇数来生成第一选择的喷射器的第一喷射序列。 然后选择紧邻第一喷射器的第二喷射器，并被识别为均匀喷射器。 此后，基于选择器被识别为偶数，为第二选择的喷射器生成第二点火序列。 第一和第二发射序列导致第一喷射器和第二喷射器在非并发时间段期间是活动的。 当检测到阵列的有缺陷的喷射器时，确定对相同基板区域的可操作的喷射器发射。 来自或与有缺陷的喷射器相关联的发射序列被转移以由可操作的喷射器使用，其中可操作的喷射器触发其自身的击发序列和有缺陷的喷射器的击发序列。

公开(公告)号：US20020073990A1

公开(公告)日：2002-06-20

申请号：US09740209

申请日：2000-12-18

Applicant: Xerox Corporation

Inventor： Jaan Noolandi ,  Babur B. Hadimioglu ,  Robert A. Sprague

IPC: A61M011/00 ,  B05B017/06 ,  A61M015/00 ,  A61M016/00

CPC classification number: B05B17/06 ,  A61M11/005 ,  A61M15/0085 ,  A61M15/02 ,  A61M15/025

Abstract: An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.

Abstract translation: 描述了用于将药物递送至肺部的改进方法和装置。 声学油墨印刷技术被修改为作为在患者的鼻子或嘴部附近产生微小液滴的吸入器。 微小的液滴容易被气流携带到病人的肺部。 吸入器本身优选地是电池操作的便携式装置，其可以容易地携带并且容易地清洁以避免污染药物。

公开(公告)号：US20020015074A1

公开(公告)日：2002-02-07

申请号：US09957710

申请日：2001-09-20

Applicant: Xerox Corporation

Inventor： Scott A. Elrod ,  Babur B. Hadimioglu ,  David Steinmetz ,  Kaiser H. Wong

IPC: B41J002/135

CPC classification number: B41J2/14008 ,  B41J2002/14322

Abstract: Low acoustic solid wave attenuation structures are formed with an electroformed nickel mold, and are incorporated within acoustic ink emitters, between the focusing lens and surface of an ink layer. The structures have characteristics of low attenuation of acoustic waves to increase the efficiency of acoustic wave transmission within the acoustic ink emitter. Using the described structures, acoustic ink printers can accurately emit materials having high viscosity, including hot melt inks.

Abstract translation: 低声波固体波衰减结构由电铸镍模形成，并且被结合在声学油墨发射器之间，在聚焦透镜和油墨层的表面之间。 该结构具有声波衰减低的特性，以增加声波发射器内声波传播的效率。 使用所述结构，声墨打印机可以精确地发射具有高粘度的材料，包括热熔油墨。