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公开(公告)号：US07247313B2
公开(公告)日：2007-07-24
申请号：US10176504
申请日：2002-06-21
Applicant: Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
Inventor： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。
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公开(公告)号：US20090136556A1
公开(公告)日：2009-05-28
申请号：US12363538
申请日：2009-01-30
Applicant: Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
Inventor： Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
CPC classification number: B05D3/0466 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D3/0473 , B05D3/048 , Y10T428/1393 , Y10T428/31507 , Y10T428/31551 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855
Abstract: A method and system of coating an implantable device, such as a stent, are provided.
Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。
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3.发明授权Rate limiting barriers for implantable devices and methods for fabrication thereof 有权用于可植入装置的速率限制障碍及其制造方法公开(公告)号：US07175873B1
公开(公告)日：2007-02-13
申请号：US10198898
申请日：2002-07-18
Applicant: Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
Inventor： Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
IPC: A61L33/10
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
Abstract translation: 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。
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4.发明授权Medicated coatings for implantable medical devices having controlled rate of release 有权具有受控释放速率的可植入医疗器械的药物涂层公开(公告)号：US07875285B1
公开(公告)日：2011-01-25
申请号：US10619727
申请日：2003-07-15
Applicant: Wouter E. Roorda , Ni Ding , Stephen D. Pacetti
Inventor： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti
IPC: A61F2/02
CPC classification number: A61L31/10 , A61F2/82 , A61F2250/0067 , A61L31/16
Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polymer having in a dry state a glass transition temperature within a range of between about 20° C. and about 55° C.
Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括在干燥状态下的玻璃化转变温度在约20℃至约55℃的范围内的聚合物。
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5.发明授权Rate limiting barriers for implantable devices and methods for fabrication thereof 有权用于可植入装置的速率限制障碍及其制造方法公开(公告)号：US07622146B2
公开(公告)日：2009-11-24
申请号：US11592632
申请日：2006-11-02
Applicant: Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
Inventor： Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08
Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
Abstract translation: 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层的药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。
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Patent Agency Ranking
公开(公告)号：US07504125B1
公开(公告)日：2009-03-17
申请号：US10040538
申请日：2001-12-28
Applicant: Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
Inventor： Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
IPC: B05D3/04
CPC classification number: B05D3/0466 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D3/0473 , B05D3/048 , Y10T428/1393 , Y10T428/31507 , Y10T428/31551 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855
Abstract: A method and system of coating an implantable device, such as a stent, are provided.
Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。
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公开(公告)号：US08007858B2
公开(公告)日：2011-08-30
申请号：US12363538
申请日：2009-01-30
Applicant: Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
Inventor： Stephen D. Pacetti , Wouter E. Roorda , Ni Ding
IPC: A61L33/00
CPC classification number: B05D3/0466 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D3/0473 , B05D3/048 , Y10T428/1393 , Y10T428/31507 , Y10T428/31551 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855
Abstract: A method and system of coating an implantable device, such as a stent, are provided.
Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。
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公开(公告)号：US07955615B2
公开(公告)日：2011-06-07
申请号：US11212376
申请日：2005-08-26
Applicant: Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
Inventor： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
IPC: A61F2/04
CPC classification number: A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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9.发明授权Polycationic peptide coatings and methods of coating implantable medical devices 有权聚阳离子肽涂层和涂覆可植入医疗器械的方法公开(公告)号：US07875286B2
公开(公告)日：2011-01-25
申请号：US11213290
申请日：2005-08-26
Applicant: Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
Inventor： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
IPC: A61F2/02
CPC classification number: A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
Abstract translation: 公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。
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10.发明授权Polycationic peptide coatings and methods of coating implantable medical devices 有权聚阳离子肽涂层和涂覆可植入医疗器械的方法公开(公告)号：US07803406B2
公开(公告)日：2010-09-28
申请号：US11213288
申请日：2005-08-26
Applicant: Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
Inventor： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
IPC: A61K9/50
CPC classification number: A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
Abstract: Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.
Abstract translation: 公开了形成包含用于医疗装置的聚阳离子肽的涂层的方法。 还公开了包含聚阳离子肽的涂层。
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