公开(公告)号：US10081792B2

公开(公告)日：2018-09-25

申请号：US14986224

申请日：2015-12-31

Applicant: Wisconsin Alumni Research Foundation

Inventor： James A. Thomson ,  Nicholas E. Propson ,  Michael P. Schwartz ,  Zhonggang Hou ,  Gene I. Uenishi ,  Igor I. Slukvin ,  William L. Murphy ,  Jue Zhang

IPC: C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C12N5/079 ,  C12N5/0789 ,  G01N33/50 ,  C12N5/0786

CPC classification number: C12N5/0622 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0645 ,  C12N5/0647 ,  C12N5/0697 ,  C12N2500/25 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2513/00 ,  G01N33/5014 ,  G01N33/5058

Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.

公开(公告)号：US20220033773A1

公开(公告)日：2022-02-03

申请号：US17405579

申请日：2021-08-18

Applicant: Wisconsin Alumni Research Foundation

Inventor： James A. Thomson ,  Nicholas E. Propson ,  Michael P. Schwartz ,  Zhonggang Hou ,  Gene I. Uenishi ,  Igor I Slukvin ,  William L. Murphy ,  Jue Zhang

IPC: C12N5/079 ,  C12N5/0789 ,  C12N5/071 ,  G01N33/50 ,  C12N5/0786

Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.

公开(公告)号：US20160186137A1

公开(公告)日：2016-06-30

申请号：US14986224

申请日：2015-12-31

Applicant: Wisconsin Alumni Research Foundation

Inventor： James A. Thomson ,  Nicholas E. Propson ,  Michael P. Schwartz ,  Zhonggang Hou ,  Gene I. Uenishi ,  Igor I. Slukvin ,  William L. Murphy ,  Jue Zhang

IPC: C12N5/079 ,  C12N5/071 ,  G01N33/50 ,  C12N5/0789

CPC classification number: C12N5/0622 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0645 ,  C12N5/0647 ,  C12N5/0697 ,  C12N2500/25 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2513/00 ,  G01N33/5014 ,  G01N33/5058

Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.

Abstract translation: 本发明涉及从人多能干细胞衍生人类造血祖细胞，原始巨噬细胞和小胶质细胞的方法。 特别地，本文提供的是从人多能干细胞获得人原始巨噬细胞和小胶质细胞的高效和可重复的方法，其中原始巨噬细胞和小胶质细胞可适用于临床相关的治疗应用。

公开(公告)号：US11124765B2

公开(公告)日：2021-09-21

申请号：US16138724

申请日：2018-09-21

Applicant: Wisconsin Alumni Research Foundation

Inventor： James A. Thomson ,  Nicholas E. Propson ,  Michael P. Schwartz ,  Zhonggang Hou ,  Gene I. Uenishi ,  Igor I. Slukvin ,  William L. Murphy ,  Jue Zhang

IPC: C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C12N5/079 ,  C12N5/0789 ,  G01N33/50 ,  C12N5/0786 ,  C12N5/0735

Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.

公开(公告)号：US20190078054A1

公开(公告)日：2019-03-14

申请号：US16138724

申请日：2018-09-21

Applicant: Wisconsin Alumni Research Foundation

Inventor： James A. Thomson ,  Nicholas E. Propson ,  Michael P. Schwartz ,  Zhonggang Hou ,  Gene I. Uenishi ,  Igor I. Slukvin ,  William L. Murphy ,  Jue Zhang

IPC: C12N5/079 ,  C12N5/0786 ,  G01N33/50 ,  C12N5/071 ,  C12N5/0789 ,  C12N5/00

Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.