公开(公告)号：US20220033773A1

公开(公告)日：2022-02-03

申请号：US17405579

申请日：2021-08-18

Applicant: Wisconsin Alumni Research Foundation

Inventor： James A. Thomson ,  Nicholas E. Propson ,  Michael P. Schwartz ,  Zhonggang Hou ,  Gene I. Uenishi ,  Igor I Slukvin ,  William L. Murphy ,  Jue Zhang

IPC: C12N5/079 ,  C12N5/0789 ,  C12N5/071 ,  G01N33/50 ,  C12N5/0786

Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.