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公开(公告)号：US11903935B2
公开(公告)日：2024-02-20
申请号：US17508321
申请日：2021-10-22
发明人： Jeffrey Milbrandt , Kow Essuman , Yo Sasaki , Aaron Diantonio , Xianrong Mao , Rajesh Devraj , Raul Eduardo Krauss , Robert Owen Hughes
IPC分类号： A61K31/4439 , A61K47/55 , A61K47/52 , A61P25/28 , A61K33/243 , A61K31/047 , A61K31/145 , A61K31/198 , A61K31/41 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4535 , A61K31/566 , A61K31/7048 , A61K31/7084 , A61K33/245 , A61K33/28 , A61K33/30
CPC分类号： A61K31/4439 , A61K31/047 , A61K31/145 , A61K31/198 , A61K31/41 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4535 , A61K31/566 , A61K31/7048 , A61K31/7084 , A61K33/243 , A61K33/245 , A61K33/28 , A61K33/30 , A61K47/52 , A61K47/55 , A61P25/28
摘要： The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
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公开(公告)号：US20230272449A1
公开(公告)日：2023-08-31
申请号：US18059838
申请日：2022-11-29
发明人： Jeffrey D. Milbrandt , Aaron DiAntonio , Kow Essuman , Xianrong Mao , Yo Sasaki , Dan Summers
IPC分类号： C12Q1/34 , A61K31/4425 , A61K31/4706 , A61K31/473 , A61K31/4965
CPC分类号： C12Q1/34 , A61K31/4425 , A61K31/4706 , A61K31/473 , A61K31/4965 , G01N2333/924
摘要： The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.
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公开(公告)号：US20200283820A1
公开(公告)日：2020-09-10
申请号：US16651196
申请日：2018-09-26
发明人： Jeffrey D. Milbrandt , Aaron DiAntonio , Kow Essuman , Xianrong Mao , Yo Sasaki , Dan Summers
IPC分类号： C12Q1/34 , A61K31/4706 , A61K31/4425 , A61K31/4965 , A61K31/473
摘要： The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.
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公开(公告)号：US09295688B2
公开(公告)日：2016-03-29
申请号：US14511701
申请日：2014-10-10
发明人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
CPC分类号： A61K31/7084 , A61K31/405 , A61K31/455 , A61K31/706 , A61K38/45 , A61K38/50 , A61K48/00 , C07H19/20 , C12N9/1241
摘要： Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
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公开(公告)号：US20150038560A1
公开(公告)日：2015-02-05
申请号：US14511701
申请日：2014-10-10
发明人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
IPC分类号： A61K31/7084
CPC分类号： A61K31/7084 , A61K31/405 , A61K31/455 , A61K31/706 , A61K38/45 , A61K38/50 , A61K48/00 , C07H19/20 , C12N9/1241
摘要： Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
摘要翻译： 公开了治疗或预防哺乳动物神经病变轴突降解的方法。 所述方法可以包括向哺乳动物施用有效量的通过增加患病和/或损伤的神经元中的沉默调节蛋白的活性而起作用的药剂。 所述方法还可以包括向哺乳动物施用有效量的通过在患病和/或损伤的神经元中增加NAD活性而起作用的药剂。 还公开了用于治疗神经病的筛选剂和用于治疗或预防神经病的重组载体的方法。
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公开(公告)号：US11253503B2
公开(公告)日：2022-02-22
申请号：US16335754
申请日：2017-09-22
发明人： Jeffrey Milbrandt , Kow Essuman , Yo Sasaki , Aaron DiAntonio , Xianrong Mao , Rajesh Devraj , Raul Eduardo Krauss , Robert Owen Hughes
IPC分类号： A61K31/4439 , A61K47/55 , A61K47/52 , A61P25/28 , A61K33/243 , A61K31/047 , A61K31/145 , A61K31/198 , A61K31/41 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4535 , A61K31/566 , A61K31/7048 , A61K31/7084 , A61K33/245 , A61K33/28 , A61K33/30
摘要： The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
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公开(公告)号：US20220409648A1
公开(公告)日：2022-12-29
申请号：US17851954
申请日：2022-06-28
发明人： Jeffrey Milbrandt , Aaron DiAntonio , Tong Wu , Amy Strickland , Adam Bloom , Yo Sasaki , Jian Zhu , Yurie Yamada
IPC分类号： A61K31/706 , A61K31/4402
摘要： Among the various aspects of the present disclosure is the provision is the provision of a SARM1 activating agent or prodrug thereof and methods of using same.
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公开(公告)号：US20160199401A1
公开(公告)日：2016-07-14
申请号：US15067449
申请日：2016-03-11
发明人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
IPC分类号： A61K31/7084 , A61K31/455 , A61K31/405 , A61K31/706
CPC分类号： A61K31/7084 , A61K31/405 , A61K31/455 , A61K31/706 , A61K38/45 , A61K38/50 , A61K48/00 , C07H19/20 , C12N9/1241
摘要： Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
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