公开(公告)号：US11253503B2

公开(公告)日：2022-02-22

申请号：US16335754

申请日：2017-09-22

申请人： Washington University ,  Disarm Therapeutics, Inc.

发明人： Jeffrey Milbrandt ,  Kow Essuman ,  Yo Sasaki ,  Aaron DiAntonio ,  Xianrong Mao ,  Rajesh Devraj ,  Raul Eduardo Krauss ,  Robert Owen Hughes

IPC分类号： A61K31/4439 ,  A61K47/55 ,  A61K47/52 ,  A61P25/28 ,  A61K33/243 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30

摘要： The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

公开(公告)号：US11903935B2

公开(公告)日：2024-02-20

申请号：US17508321

申请日：2021-10-22

申请人： Washington University ,  Disarm Therapeutics, Inc.

发明人： Jeffrey Milbrandt ,  Kow Essuman ,  Yo Sasaki ,  Aaron Diantonio ,  Xianrong Mao ,  Rajesh Devraj ,  Raul Eduardo Krauss ,  Robert Owen Hughes

IPC分类号： A61K31/4439 ,  A61K47/55 ,  A61K47/52 ,  A61P25/28 ,  A61K33/243 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30

CPC分类号： A61K31/4439 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/243 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30 ,  A61K47/52 ,  A61K47/55 ,  A61P25/28

摘要： The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

公开(公告)号：US20230272449A1

公开(公告)日：2023-08-31

申请号：US18059838

申请日：2022-11-29

申请人： Washington University

发明人： Jeffrey D. Milbrandt ,  Aaron DiAntonio ,  Kow Essuman ,  Xianrong Mao ,  Yo Sasaki ,  Dan Summers

IPC分类号： C12Q1/34 ,  A61K31/4425 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/4965

CPC分类号： C12Q1/34 ,  A61K31/4425 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/4965 ,  G01N2333/924

摘要： The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.

公开(公告)号：US20200283820A1

公开(公告)日：2020-09-10

申请号：US16651196

申请日：2018-09-26

申请人： Washington University

发明人： Jeffrey D. Milbrandt ,  Aaron DiAntonio ,  Kow Essuman ,  Xianrong Mao ,  Yo Sasaki ,  Dan Summers

IPC分类号： C12Q1/34 ,  A61K31/4706 ,  A61K31/4425 ,  A61K31/4965 ,  A61K31/473

摘要： The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.