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    Delivery of hydroxy carboxylic acids
    1.
    发明授权
    Delivery of hydroxy carboxylic acids 有权
    递送羟基羧酸

    公开(公告)号：US6143309A

    公开(公告)日：2000-11-07

    申请号：US148675

    申请日：1998-09-04

    Applicant: Gary E. Legrow ,  W. Leonard Terry, Jr.

    Inventor： Gary E. Legrow ,  W. Leonard Terry, Jr.

    IPC: A61K8/55 ,  A01N55/00 ,  A61K6/00 ,  A61K8/00 ,  A61K8/06 ,  A61K8/58 ,  A61K8/89 ,  A61K8/891 ,  A61K31/695 ,  A61K31/74 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00

    CPC classification number: A61Q19/00 ,  A61K8/585 ,  A61K2800/75 ,  A61Q19/08

    Abstract: The present invention provides greater than 99% pure bis(triorganosilyl)hydroxycarboxylates of the general formulae:R.sub.3 SiO--CHR.sup.1 --COO--SiR.sub.3R.sub.3 SiO--CHR.sup.1 --R.sup.2 COO--SiR.sub.3wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R.sup.1 may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R.sup.2 is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99% pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarboxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.

    Abstract translation: 本发明提供了以下通式的大于99％的纯双（三有机甲硅烷基）羟基羧酸盐：R3SiO-CHR1-COO-SiR3 R3SiO-CHR1-R2COO-SiR3，其中每个R独立地为具有1个以上的1价直链或支链烷基或烯基 至约6个碳原子或芳基，R 1可以是氢，具有1至约18个碳原子的一价直链或支链烷基或芳基，R 2是二价直链或支链烷基，其具有 1至约18个碳原子，芳基或具有7至约18个碳原子的直链或支链烷芳基; 包括与相应的羟基羧酸的六甲基二硅氮烷的三甲基甲硅烷基化的双（三甲基甲硅烷基）羟基羧酸盐的方法; 包含溶解在非质子介质中的大于99％的纯双（三甲基甲硅烷基）羟基羧酸盐的化妆品制剂; 以及将羟基羧酸递送到表皮而没有表皮或角质层的明显刺激或炎症的方法。

    Delivery of hydroxy carboxylic acids
    2.
    发明授权
    Delivery of hydroxy carboxylic acids 失效

    公开(公告)号：US06267977B1

    公开(公告)日：2001-07-31

    申请号：US09614628

    申请日：2000-07-12

    Applicant: Gary E. LeGrow ,  W. Leonard Terry, Jr.

    Inventor： Gary E. LeGrow ,  W. Leonard Terry, Jr.

    IPC: A61K700

    CPC classification number: A61Q19/00 ,  A61K8/585 ,  A61K2800/75 ,  A61Q19/08

    Abstract: The present invention provides greater than 99% pure bis(triorganosilyl)hydroxycarboxylates of the general formulae: R3SiO—CHR1—COO—SiR3 R3SiO—CHR1—R2COO—SiR3 wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R1 may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R2 is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99% pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarboxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.

    Organosilicone gel compositions for personal care
    4.
    发明授权
    Organosilicone gel compositions for personal care 失效
    有机硅凝胶组合物用于个人护理

    公开(公告)号：US06258365B1

    公开(公告)日：2001-07-10

    申请号：US09149964

    申请日：1998-09-09

    Applicant: Gary E. LeGrow ,  W. Leonard Terry, Jr.

    Inventor： Gary E. LeGrow ,  W. Leonard Terry, Jr.

    IPC: A61K900

    CPC classification number: A61Q19/007 ,  A61K8/042 ,  A61K8/585 ,  A61K8/89 ,  Y10S514/944

    Abstract: The present invention relates to compositions comprising non-toxic and safe for human contact and ingestion volatile or non-volatile silicone-aliphatic hydrocarbon hybrid fluids and a non-volatile silicone-aliphatic hydrocarbon hybrid wax which have the physical consistency of a gel which are of use in a wide variety of personal care applications and when applied to the human skin components within these compositions adsorb quickly into the upper layers of the status corneum, while other components form non-tacky occlusive films on the outer surface of the stratum corneum.

    Abstract translation: 本发明涉及包含无毒且安全的用于人接触和摄入挥发性或非挥发性硅氧烷 - 脂族烃混合流体的组合物和具有凝胶物理稠度的非挥发性硅脂 - 脂族烃混合蜡 用于各种个人护理应用中，并且当应用于人类皮肤时，这些组合物中的组分在快速吸收状态角质层的上层中，而其它组分在角质层的外表面上形成非粘性闭塞膜。

    Delivery of hydroxy carboxylic acids
    6.
    发明授权
    Delivery of hydroxy carboxylic acids 失效
    递送羟基羧酸

    公开(公告)号：US06228380B1

    公开(公告)日：2001-05-08

    申请号：US09614581

    申请日：2000-07-12

    Applicant: Gary E. LeGrow ,  W. Leonard Terry, Jr.

    Inventor： Gary E. LeGrow ,  W. Leonard Terry, Jr.

    IPC: A61K600

    CPC classification number: A61Q19/00 ,  A61K8/585 ,  A61K2800/75 ,  A61Q19/08

    Abstract: The present invention provides greater than 99% pure bis(triorganosilyl)hydroxycarboxylates of the general formulae: R3SiO—CHR1—COO—SiR3 R3SiO—CHR1—R2COO—SiR3 wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R1 may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R2 is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99% pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarboxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.

    Abstract translation: 本发明提供了以下通式的大于99％的纯双（三有机甲硅烷基）羟基羧酸盐：其中每个R独立地为具有1至约6个碳原子的单价直链或支链烷基或烯基，或芳基，R 1可以 是氢，具有1至约18个碳原子的单价直链或支链烷基或芳基，并且R 2是具有1至约18个碳原子的二价直链或支链烷基，芳基或 具有7至约18个碳原子的直链或支链烷芳基; 包括与相应的羟基羧酸的六甲基二硅氮烷的三甲基甲硅烷基化的双（三甲基甲硅烷基）羟基羧酸盐的方法; 包含溶解在非质子介质中的大于99％的纯双（三甲基甲硅烷基）羟基羧酸盐的化妆品制剂; 以及将羟基羧酸递送到表皮而没有表皮或角质层的明显刺激或炎症的方法。

    High softening temperature synthetic alkylsilicone wax
    7.
    发明授权
    High softening temperature synthetic alkylsilicone wax 失效
    高软化温度合成烷基硅氧烷蜡

    公开(公告)号：US07579425B2

    公开(公告)日：2009-08-25

    申请号：US11582089

    申请日：2006-10-17

    Applicant: W. Leonard Terry, Jr. ,  Gary E. LeGrow

    Inventor： W. Leonard Terry, Jr. ,  Gary E. LeGrow

    IPC: C08G77/04

    CPC classification number: C09G1/16 ,  C08G77/38 ,  C08G77/442

    Abstract: A method for making high softening point linear and cyclic alkylsilicone waxes includes reacting a C30+ alpha olefin wax with a silicone hydride polymer in the presence of a catalyst. The high softening point linear and cyclic alkylsilicone waxes have softening points approximating those of natural waxes and, in consequence, can be used in applications which traditionally employ natural waxes.

    Abstract translation: 制备高软化点线性和环状烷基硅氧烷蜡的方法包括在催化剂存在下使C30 +α烯烃蜡与硅氢化合物聚合物反应。 高软化点线性和环状烷基硅氧烷蜡具有接近天然蜡的软化点，因此可用于传统上使用天然蜡的应用中。

    Protective coatings having branched trimethylsilylated alkylsilsesquioxane emulsions
    9.
    发明授权
    Protective coatings having branched trimethylsilylated alkylsilsesquioxane emulsions 失效
    具有支链三甲硅烷基化烷基倍半硅氧烷乳液的保护涂层

    公开(公告)号：US06770123B2

    公开(公告)日：2004-08-03

    申请号：US10201173

    申请日：2002-07-23

    Applicant: Gary E. LeGrow ,  W. Leonard Terry, Jr.

    Inventor： Gary E. LeGrow ,  W. Leonard Terry, Jr.

    IPC: C09D502

    CPC classification number: C08J3/02 ,  B60C13/002 ,  C07F7/0838 ,  C08G77/04 ,  C08J7/047 ,  C08J2383/04 ,  C08J2483/00 ,  C09K3/18 ,  Y10T428/31663

    Abstract: A protective coating for organic substrates includes an emulsion having a branched trimethylsilylated alkylsilsesquioxane. The trimethylsilylated alkylsilsesquioxane has the formula: Me3SiO[R(Me3SiO)SiO]xSiMe3 wherein R is a substituted or unsubstituted linear or branched monovalent hydrocarbon substituent with from 6 to 14 carbon atoms, Me is Methyl, and x ranges from 1 to 6. Also disclosed is a method of rendering an organic surface repellent to water, dust and dirt by treating the organic surface with an effective amount of the foregoing emulsion. The organic surface being treated can be a rubber surface such as wires, cables, the sidewall of automotive tires, footwear, and coated fabrics. The surface can also be a synthetic plastic surface such as automotive dashboards, automotive trim (both interior and exterior), automotive upholstery, flooring, residential siding, and piping.

    Abstract translation: 有机基材的保护涂层包括具有支链三甲基硅烷基化烷基硅倍半氧烷的乳液。 三甲基甲硅烷基化烷基倍半硅氧烷具有下式：其中R是具有6至14个碳原子的取代或未取代的直链或支链一价烃取代基，Me是甲基，x在1至6的范围内。还公开了一种使有机表面 通过用有效量的上述乳液处理有机表面，防止水，灰尘和污垢。 被处理的有机表面可以是橡胶表面，例如电线，电缆，汽车轮胎的侧壁，鞋类和涂层织物。 表面也可以是合成塑料表面，例如汽车仪表板，汽车内饰件（内部和外部），汽车内饰，地板，住宅壁板和管道。

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