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    Highly concentrated free-flowing pearly lustre concentrates
    1.
    发明授权
    Highly concentrated free-flowing pearly lustre concentrates 有权
    高度浓缩的自由流动珍珠光泽浓缩液

    公开(公告)号：US06835700B1

    公开(公告)日：2004-12-28

    申请号：US10009285

    申请日：2001-11-06

    申请人： Claus Nieendick ,  Karl Heinz Schmid ,  Mirella Nalborczyk

    发明人： Claus Nieendick ,  Karl Heinz Schmid ,  Mirella Nalborczyk

    IPC分类号： A61K700

    CPC分类号： A61Q5/02 ,  A61K8/39 ,  C07H15/04 ,  C08L91/08 ,  C11D3/0089

    摘要： A highly concentrated flowable pearlizing concentrate is comprised of: (a) from about 25 to about 45% by weight of a pearlizing wax; (b) from about 25 to about 40% by weight of nonionic, amphoteric, zwitterionic and/or cationic emulsifier and; (c) from about 0.5 to about 15% by weight of a polyol ester and the remainder water. The sum of components (a), (b) and (c) is at least 55% by weight. The concentrates are useful cosmetic applications such as in hair shampoos and shower gels.

    摘要翻译： 高度浓缩的可流动的珠光浓缩物包括：（a）约25至约45重量％的珠光蜡; （b）约25至约40重量％的非离子，两性，两性离子和/或阳离子乳化剂; （c）约0.5至约15重量％的多元醇酯，其余为水。 组分（a），（b）和（c）的总和至少为55重量％。 浓缩物是有用的化妆品应用，例如在洗发剂和沐浴露中。

    Compositions and methods for softening, thinning and removing hyperkeratotic tissue
    2.
    发明授权
    Compositions and methods for softening, thinning and removing hyperkeratotic tissue 有权
    用于软化，减薄和去除角化组织的组合物和方法

    公开(公告)号：US06835385B2

    公开(公告)日：2004-12-28

    申请号：US10430029

    申请日：2003-05-06

    申请人： Carol J. Buck

    发明人： Carol J. Buck

    IPC分类号： A61K700

    CPC分类号： A61Q19/007 ,  A61K8/66 ,  A61K38/482 ,  A61K2800/28 ,  A61Q19/00

    摘要： Novel compositions and methods for treatment of hyperkeratotic mammalian tissue are disclosed employing proteolytic enzymes originally developed for the hydrolysis of food-related proteins and currently commonly used as food grade meat tenderizers and flavor enhancers. The compositions containing these proteinases soften, thin and exfoliate hyperkeratotic formations on the skin, including calluses, corns, dry, scaling/flaking skin and keratoses without harming surrounding tissue by selective lysing of hyperkeratotic tissue. Such enzymes accomplish this by lysing only the 10-end peptide bonds of keratin protein, the dominant protein component of hyperkeratotic skin.

    摘要翻译： 公开了用于治疗角化过度的哺乳动物组织的新型组合物和方法，其使用最初开发用于食品相关蛋白水解的蛋白水解酶，目前通常用作食品级肉嫩蛋白和增味剂。 含有这些蛋白酶的组合物通过选择性裂解角化剂组织而软化，减薄和剥离皮肤上的角质构成组织，包括愈伤组织，玉米，干燥，结垢/剥落皮肤和角化病，而不伤害周围组织。 这样的酶通过仅裂解角蛋白蛋白的10端肽键来实现，这是角质形成皮肤的主要蛋白质组分。

    Pomegranate fruit extract compositions for treating dermatological disorders
    3.
    发明授权
    Pomegranate fruit extract compositions for treating dermatological disorders 有权
    用于治疗皮肤病的石榴果实提取物组合物

    公开(公告)号：US06800292B1

    公开(公告)日：2004-10-05

    申请号：US09501217

    申请日：2000-02-10

    申请人： Howard Murad

    发明人： Howard Murad

    IPC分类号： A61K700

    CPC分类号： A61Q17/04 ,  A61K8/97 ,  A61K36/185 ,  A61K36/73 ,  A61K36/736 ,  A61K36/752 ,  A61K36/87 ,  A61K36/88 ,  A61K45/06 ,  A61K2800/92 ,  A61Q19/00 ,  A61K2300/00

    摘要： This application relates to dermatological agents for treating dermatological disorders. The dermatological agents include a therapeutically effective amount of at least one fruit extract in an amount sufficient to neutralize free radicals, a moisturizing agent in an amount sufficient to facilitate hydration of the skin, and a pharmaceutically acceptable carrier. Preferred fruit extracts include extracts from apricots, apples, peaches, pears, pineapples, papayas, pomegranates, cherries, kiwis, tangerines, grapes, and oranges. The most preferred extract is extract from pomegranate.

    摘要翻译： 本申请涉及用于治疗皮肤病的皮肤病药物。 皮肤病学试剂包括治疗有效量的足以中和自由基的量的至少一种水果提取物，足以促进皮肤水合的量的保湿剂和药学上可接受的载体。 优选的水果提取物包括来自杏，苹果，桃子，梨，菠萝，番木瓜，石榴，樱桃，猕猴桃，橘子，葡萄和橙子的提取物。 最优选的提取物是石榴提取物。

    Plasticiser nails
    4.
    发明授权
    Plasticiser nails 失效
    增塑指甲

    公开(公告)号：US06797261B1

    公开(公告)日：2004-09-28

    申请号：US10128593

    申请日：2002-04-23

    申请人： Loc Thi Le

    发明人： Loc Thi Le

    IPC分类号： A61K700

    CPC分类号： A61K8/042 ,  A45D29/00 ,  A61K8/36 ,  A61K8/368 ,  A61K8/38 ,  A61K8/44 ,  A61K8/8152 ,  A61K8/87 ,  A61K2800/81 ,  A61Q3/00 ,  A61Q3/02

    摘要： The present invention 10 discloses a method of applying, drying and bonding fingernail polish 26, and more particularly, to the bonding of protective coatings on a fingernail 16 by means of a prescribed process. The preferred method of the present invention 10 is to provide a simple but unique method of drying and bonding protective nail coatings that fortifies the fingernail. This unique method provides for long-lasting, non-yellowing, natural-looking nails 16 that can be worn with or without nail polish 26. The present invention 10 requires the use of instruments including: a UV lamp, acrylic drill, nail file, coarse and medium sanding paper, gel brush, scissors, flat brush, steel brush, cuticle pusher, orange stick, flat brush handle, and anything that is considered tube, squeeze instruments foil or plastic bag. As part of the method of the present invention 10, an acrylic powder blend is mixed with a UV gel compound to form a gel blend/mix.

    摘要翻译： 本发明10公开了一种施用，干燥和结合指甲擦亮剂26的方法，更具体地说，涉及通过规定的方法在指甲16上粘合保护涂层。 本发明10的优选方法是提供一种简单但独特的干燥和粘合保护性指甲涂层的方法，其强化指甲。 这种独特的方法提供了可以使用或不用指甲油佩戴的持久，不发黄，自然的指甲16.本发明10需要使用仪器，包括：UV灯，丙烯酸钻，指甲锉， 粗中中砂纸，凝胶刷，剪刀，平刷，钢刷，角质层推杆，橙色棒，平刷柄，任何被认为是管，挤压仪器箔或塑料袋的物品。 作为本发明方法10的一部分，将丙烯酸粉末混合物与UV凝胶化合物混合以形成凝胶共混物/混合物。

    Biodegradable bioadhesive controlled release system of nano-particles for oral care products
    5.
    发明授权
    Biodegradable bioadhesive controlled release system of nano-particles for oral care products 失效
    用于口腔护理产品的纳米颗粒的可生物降解生物粘附控制释放系统

    公开(公告)号：US06790460B2

    公开(公告)日：2004-09-14

    申请号：US10376761

    申请日：2003-02-28

    申请人： Adi Shefer ,  Shmuel David Shefer

    发明人： Adi Shefer ,  Shmuel David Shefer

    IPC分类号： A61K700

    CPC分类号： A61Q11/00 ,  A61K8/0241 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/5123 ,  A61K2800/413 ,  A61K2800/622 ,  A61K2800/652 ,  B82Y5/00

    摘要： The present invention relates to a controlled release system useful for site specific delivery of biologically active ingredients or sensory markers, over an extended period of time, targeting biological surfaces comprising the oral cavity and mucous membranes of various tissues, as well as the controlled release of the biological active ingredients or sensory markers. The controlled release system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns, which comprises a biodegradable solid hydrophobic core and a bioadhesive/mucoadhesive positively charged surface. The invention also relates to the use of the nano-particles of the present invention in consumer oral hygiene products, such as toothpaste or mouthwash, for treatment and prevention of periodontal disease. The nano-particles of the present invention are particularly effective for targeted controlled delivery of biological active ingredients into the periodontal pocket. The present invention also provides synchronizing the release of the biologically active ingredient with that of the sensory markers to convey to the consumer the product performance and signal that a new application of the product is needed.

    摘要翻译： 本发明涉及一种控制释放系统，其可用于生物活性成分或感官标记物的特异性递送，其在延长的时间段内靶向包含各种组织的口腔和粘膜的生物学表面，以及受控释放 生物活性成分或感官标记物。 本发明的控制释放系统是平均粒径为约0.01微米至约10微米的纳米颗粒，其包含可生物降解的固体疏水性芯和生物粘附/粘膜粘附带正电的表面。 本发明还涉及本发明的纳米颗粒在消费者口腔卫生产品如牙膏或漱口剂中用于治疗和预防牙周病的用途。 本发明的纳米颗粒对于将生物活性成分靶向控制递送到牙周袋中是特别有效的。 本发明还提供使生物活性成分与感官标记物的释放同步，以向消费者传达产品性能并且指示需要新产品的应用。

    Cosmetic or dermatological composition comprising at least one alkynyl carbamate and at least one polyol
    9.
    发明授权
    Cosmetic or dermatological composition comprising at least one alkynyl carbamate and at least one polyol 失效
    包含至少一种炔基氨基甲酸酯和至少一种多元醇的化妆品或皮肤病学组合物

    公开(公告)号：US06759051B2

    公开(公告)日：2004-07-06

    申请号：US09449924

    申请日：1999-12-02

    申请人： Didier Saint-Leger

    发明人： Didier Saint-Leger

    IPC分类号： A61K700

    CPC分类号： A61K8/44 ,  A61K8/345 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q19/00

    摘要： The present invention consists of a cosmetic or dermatological composition comprising, in a physiologically acceptable medium: at least one alkynyl carbamate of formula (I) below:  in which: A denotes a halogen atom R denotes a hydrogen atom, an alkyl group, a hydroxyalkyl group, and at least one polyol chosen from non-etherified polyols, and (poly)alkyl or (poly)alkenyl polyol ethers; these polyols containing from 4 to 28 carbon atoms and from 2 to 6 hydroxyl functions, with the proviso that at least two of these hydroxyl functions are free; uses of these compositions and a cosmetic treatment process using these compositions.

    摘要翻译： 本发明包括化妆品或皮肤病学组合物，其在生理学上可接受的培养基中包含：至少一种式（I）的炔基氨基甲酸酯：其中：A表示卤素原子，R表示氢原子，烷基，羟基烷基 和至少一种选自非醚化多元醇和（聚）烷基或（多）烯基多元醇醚的多元醇; 这些含有4至28个碳原子和2至6个羟基官能团的多元醇，条件是这些羟基官能团中的至少两个是游离的;这些组合物的使用和使用这些组合物的美容处理方法。

    Method of skin care and/or treatment using lipoic acid
    10.
    发明授权
    Method of skin care and/or treatment using lipoic acid 有权
    使用硫辛酸进行护肤和/或治疗的方法

    公开(公告)号：US06752999B2

    公开(公告)日：2004-06-22

    申请号：US09961766

    申请日：2001-09-24

    申请人： Nicholas V. Perricone

    发明人： Nicholas V. Perricone

    IPC分类号： A61K700

    CPC分类号： A61Q19/004 ,  A61K8/4986 ,  A61K31/385 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2300/00

    摘要： Methods for the prevention and treatment of skin damage, and, arising from exposure to ultraviolet or solar radiation, using lipoic acid in a dermatologically acceptable carrier that can be topically applied to the skin areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate and/or tocotrienol and/or an &agr;-hydroxy acid such as glycolic acid is applied with the lipoic acid and/or its derivatives in some embodiments.

    摘要翻译： 用于预防和治疗皮肤损伤的方法，以及由于暴露于紫外线或太阳辐射引起的，可在局部应用于皮肤区域的皮肤病学可接受的载体中使用硫辛酸。 在一些实施方案中，将硫辛酸和/或其衍生物施用抗坏血酸的脂溶性脂肪酸酯如抗坏血酸棕榈酸酯和/或生育三烯酚和/或α-羟基酸如乙醇酸。