公开(公告)号：US06791077B1

公开(公告)日：2004-09-14

申请号：US10643591

申请日：2003-08-19

Applicant: Vincent R. Farnsworth

Inventor： Vincent R. Farnsworth

IPC: H01J3705

CPC classification number: H01J49/009 ,  H01J49/421

Abstract: An improved mass analyzer capable of parallel processing one or more analytes is set fourth. The mass analyzer comprises a mass filter unit having a plurality of ion selection chambers disposed in parallel with one another. Each of the plurality of ion selection chambers respectively includes an ion inlet lying in an inlet plane and an ion outlet lying in an outlet plane. The mass analyzer further includes a plurality of electrodes disposed in the ion selection chambers and at least one RF signal generator connected to the plurality of electrodes to produce a non-rotating, oscillating electric field in each ion selection chambers. A plurality of ion injectors are each coupled to inject an ion beam into the ion inlet of a respective ion selection chambers. The ions meeting predetermined m/Q requirements pass through the ion selection chambers to contact corresponding detection surfaces of an ion detector array. The mass filter array may also be constructed so that at least one pair of ion selection chambers share at least one common field generating electrode.

Abstract translation: 能够并行处理一种或多种分析物的改进的质量分析仪被设置为第四。 质量分析器包括质量过滤器单元，其具有彼此平行设置的多个离子选择室。 多个离子选择室中的每一个分别包括位于入口平面中的离子入口和位于出口平面中的离子出口。 质量分析器还包括设置在离子选择室中的多个电极和连接到多个电极的至少一个RF信号发生器，以在每个离子选择室中产生不旋转的振荡电场。 多个离子注入器各自耦合以将离子束注入相应离子选择室的离子入口。 满足预定m / Q要求的离子通过离子选择室以接触离子检测器阵列的相应检测表面。 质量过滤器阵列还可以被构造成使得至少一对离子选择室共享至少一个公共场产生电极。

公开(公告)号：US06777670B1

公开(公告)日：2004-08-17

申请号：US10249320

申请日：2003-03-31

Applicant: Vincent R. Farnsworth

Inventor： Vincent R. Farnsworth

IPC: H01J3705

CPC classification number: H01J49/009 ,  H01J49/421

Abstract: An improved mass analyzer capable of parallel processing one or more analytes is set forth. The mass analyzer comprises a mass filter unit having a plurality of ion selection chambers disposed in parallel with one another. Each of the plurality of ion selection chambers respectively includes an ion inlet lying in an inlet plane and an ion outlet lying in an outlet plane. The mass analyzer further includes a plurality of electrodes disposed in the ion selection chambers and at least one RF signal generator connected to the plurality of electrodes to produce a non-rotating, oscillating electric field in each ion selection chambers. A plurality of ion injectors are each coupled to inject an ion beam into the ion inlet of a respective ion selection chambers. The ions meeting predetermined m/Q requirements pass through the ion selection chambers to contact corresponding detection surfaces of an ion detector array. The mass filter array may also be constructed so that at least one pair of ion selection chambers share at least one common field generating electrode.

Abstract translation: 阐述了能够并行处理一种或多种分析物的改进的质量分析仪。 质量分析器包括质量过滤器单元，其具有彼此平行设置的多个离子选择室。 多个离子选择室中的每一个分别包括位于入口平面中的离子入口和位于出口平面中的离子出口。 质量分析器还包括设置在离子选择室中的多个电极和连接到多个电极的至少一个RF信号发生器，以在每个离子选择室中产生不旋转的振荡电场。 多个离子注入器各自耦合以将离子束注入相应离子选择室的离子入口。 满足预定m / Q要求的离子通过离子选择室以接触离子检测器阵列的相应检测表面。 质量过滤器阵列还可以被构造成使得至少一对离子选择室共享至少一个公共场产生电极。

公开(公告)号：US5082788A

公开(公告)日：1992-01-21

申请号：US396684

申请日：1989-08-22

Applicant: Vincent R. Farnsworth ,  Paul K. Cartier, III

Inventor： Vincent R. Farnsworth ,  Paul K. Cartier, III

IPC: B01J19/00 ,  C40B40/10 ,  C40B60/14

CPC classification number: B01J19/0046 ,  B01J2219/00394 ,  B01J2219/00398 ,  B01J2219/0059 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14

Abstract: A method is provided for sequencing peptides and proteins in which the coupling and cleavage reagents are supplied through a valve block assembly with internal delivery channels and a common outlet channel. The outlet channel communicates with a reaction chamber in which the sample is placed. Access of reactants to the delivery channels is controlled by diaphragm valves, preferably equipped with relief grooves to accommodate deformation of the diaphragm. Reservoirs feeding the delivery channels have an inert atmosphere controlled by pressurizing and venting channels in the valve block. Exposure of plastic tubing to oxygen is kept to a minimum. Reactants are thereby supplied without significant cross-contamination or oxidative decomposition.

Abstract translation: 提供了一种测序肽和蛋白质的方法，其中偶联和切割试剂通过具有内部递送通道和公共出口通道的阀块组件供应。 出口通道与放置样品的反应室连通。 反应物到达输送通道的通道由隔膜阀控制，隔膜阀优选配备有释放槽以适应隔膜的变形。 供给输送通道的储存器具有通过对阀块中的通道加压和排放来控制的惰性气氛。 将塑料管暴露在氧气中保持最小。 从而提供反应物而没有明显的交叉污染或氧化分解。

公开(公告)号：US4773446A

公开(公告)日：1988-09-27

申请号：US901327

申请日：1986-08-27

Applicant: Vincent R. Farnsworth ,  Paul K. Cartier, III

Inventor： Vincent R. Farnsworth ,  Paul K. Cartier, III

IPC: F16K7/16 ,  B01J19/00 ,  C40B40/10 ,  C40B60/14 ,  F16K7/00 ,  F16K11/24

CPC classification number: B01J19/0046 ,  B01J2219/00394 ,  B01J2219/00398 ,  B01J2219/0059 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14 ,  Y10T137/3124 ,  Y10T137/314 ,  Y10T137/86332 ,  Y10T137/87684

Abstract: A valve block assembly with internal delivery channels and a common outlet channel is provided. The assembly has two delivery valve surfaces with access to the common channel. The common channel comprises easily cleaned linear sections running alternately from one surface to the other, and connecting surface grooves at the valve sites. Diaphragm valves with relief grooves to accommodate deformation of the diaphragm are provided. The V-like cross-section of the connecting grooves of the common channel and the conical shape of the nearby outlet of a delivery channel assure that the valve may be opened by only a small actuating force. Reservoirs feeding the delivery channels have an inert atmosphere controlled by pressurizing and venting channels in the valve block. Exposure of plastic tubing to oxygen is kept to a minimum. The assembly is particularly adapted for use in a protein sequencer to supply reactants without cross-contamination or oxidative decomposition.

Abstract translation: 提供具有内部输送通道和公共出口通道的阀块组件。 该组件具有两个可进入公共通道的输送阀表面。 公共通道包括从一个表面到另一个表面交替行进的容易清洁的线性部分，以及在阀位处的连接表面凹槽。 提供具有用于适应隔膜变形的释放槽的隔膜阀。 公共通道的连接槽的V形横截面和输送通道的附近出口的锥形形状确保仅通过小的致动力来打开阀。 供给输送通道的储存器具有通过对阀块中的通道加压和排放来控制的惰性气氛。 将塑料管暴露在氧气中保持最小。 该组件特别适用于蛋白质测序仪，以提供反应物而不会发生交叉污染或氧化分解。

公开(公告)号：US5364068A

公开(公告)日：1994-11-15

申请号：US171877

申请日：1993-12-22

Applicant: Vincent R. Farnsworth ,  Paul F. Cartier, III

Inventor： Vincent R. Farnsworth ,  Paul F. Cartier, III

IPC: B01J4/00 ,  B01J19/00 ,  C40B40/10 ,  C40B60/14 ,  F16K31/10

CPC classification number: B01J4/001 ,  B01J19/0046 ,  B01J2219/00394 ,  B01J2219/00398 ,  B01J2219/0059 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14 ,  Y10T137/3124 ,  Y10T137/314 ,  Y10T137/87684 ,  Y10T137/87917

Abstract: A valve block assembly with internal delivery channels and a common outlet channel is provided. Access of reactants to the delivery channels is controlled by diaphragm valves, preferably equipped with relief grooves to accommodate deformation of the diaphragm. Reservoirs feeding the delivery channels have an inert atmosphere controlled by pressurizing and venting channels in the valve block. Exposure of plastic tubing to oxygen is kept to a minimum. The assembly is particularly adapted for use in a DNA or protein sequencer to supply reactants without cross-contamination or oxidative decomposition.

公开(公告)号：US5167397A

公开(公告)日：1992-12-01

申请号：US806179

申请日：1991-12-13

Applicant: Vincent R. Farnsworth

Inventor： Vincent R. Farnsworth

IPC: F16K31/06

CPC classification number: F16K31/0672

Abstract: A chemically inert diaphragm valve is provided in which the diaphragm is attached to the plunger of a solenoid by a threaded insert. The diaphragm material, which is preferably a relatively flexible, chemically inert material such as Kalrez or Chem-Raz, is molded around one end of a machined piece with the other end of the piece being threaded. The threaded end may be received by the tapped end of a solenoid plunger. The piece contained within the diaphragm material acts to stabilize cold-flow at the valve site as well as perform the valving function.

Abstract translation: 提供了一种化学惰性的隔膜阀，其中隔膜通过螺纹插入件附接到螺线管的柱塞。 膜片材料优选为相对柔性的，化学惰性的材料，例如Kalrez或Chem-Raz，围绕加工件的一端被模制，该件的另一端是螺纹的。 螺纹端可以被螺线管柱塞的螺纹端接收。 隔膜材料中包含的部件用于稳定阀位处的冷流以及执行阀门功能。

公开(公告)号：US07186972B2

公开(公告)日：2007-03-06

申请号：US10692301

申请日：2003-10-23

Applicant: Vincent R. Farnsworth

Inventor： Vincent R. Farnsworth

IPC: H01J49/40 ,  H01J49/28 ,  B01D59/44

CPC classification number: H01J49/22 ,  G01N30/72 ,  H01J49/40

Abstract: A time-of-flight mass analyzer having improved mass resolution without mandating a corresponding increase in instrument size is disclosed. The analyzer includes an ionizer that generates the ions that are to be analyzed. These ions are introduced to an ion flight path, at least a portion of which is aligned with a linear axis. The portion of the ion path that is aligned with the linear axis includes a region having a substantially static electric field with non-linear equipotential field lines that circumvent the linear axis. Ions either enter the substantially static electric field with a velocity component that is directed along the linear axis or have such a velocity component imparted to them once they have been trapped in the substantially static electric field. As a result of the combined effects of the linear velocity component and the non-linear field, the ions make multiple circumnavigating trips about the linear axis as they concurrently travel in the direction of the linear axis. Consequently, the ions travel along a significantly longer flight path when compared to a flight path in which the ions solely travel linearly along the axis. In one embodiment, the concurrent motions of the ions in the direction of the linear axis and along the equipotential field lines about the linear axis define a substantially helical ion trajectory. This provides a larger distance along which ions having close, but different, m/z may be separated in time thereby providing an instrument having higher resolution.

Abstract translation: 公开了一种具有改进的质量分辨率而不强制相应的仪器尺寸增加的飞行时间质量分析仪。 分析仪包括产生要分析的离子的离子发生器。 这些离子被引入离子飞行路径，其至少一部分与线性轴对齐。 与线性轴线对准的离子路径的部分包括具有基本上静止的电场的区域，其具有围绕线性轴线的非线性等电场线。 离子或者以沿着线性轴线指向的速度分量进入基本上静态的电场，或者一旦它们被捕获在基本静电场中，就具有赋予它们的速度分量。 作为线速度分量和非线性场的组合效应的结果，离子在线性轴线的同时行进时，绕线性轴线进行多个循环跳闸。 因此，与离子仅沿着轴线行进的飞行路径相比，离子沿着显着更长的飞行路径行进。 在一个实施例中，离子在线性轴线的方向上并沿着等轴电场线绕线性轴线的同时运动限定了基本上螺旋形的离子轨迹。 这提供了更大的距离，沿着该距离可以将具有接近但不同的m / z的离子在时间上分离，从而提供具有更高分辨率的仪器。

公开(公告)号：US07057167B2

公开(公告)日：2006-06-06

申请号：US10940466

申请日：2004-09-14

Applicant: Vincent R. Farnsworth

Inventor： Vincent R. Farnsworth

IPC: H01J37/05

CPC classification number: H01J49/004

Abstract: A method for filtering ions having a selected mass-to-charge ratio is set forth. In accordance with the method, one or more ions are injected into ion inlets of first and second ion selection chambers in a generally concurrent manner. The first and second ion selection chambers each have a corresponding ion outlet. The first ion selection chamber has a first plurality of electrodes disposed between the respective ion inlet and ion outlet and the said second ion selection chamber has a second plurality of electrodes disposed between its respective ion inlet and ion outlet. One or more RF signals are applied to the first and second plurality of electrodes to generate a rotating electric field respectively in each of the first and second ion selection chambers. Ions exiting the ion outlets of the first and second ion selection chambers, for example, to generate a mass spectrum for the injected ions.

Abstract translation: 阐述了一种用于过滤具有选定的质荷比的离子的方法。 按照该方法，一个或多个离子以大致并发的方式注入第一离子选择室和第二离子选择室的离子入口。 第一和第二离子选择室各自具有相应的离子出口。 第一离子选择室具有设置在相应的离子入口和离子出口之间的第一多个电极，并且所述第二离子选择室具有设置在其各自的离子入口和离子出口之间的第二多个电极。 将一个或多个RF信号施加到第一和第二多个电极，以分别在第一和第二离子选择室中的每一个中产生旋转电场。 离开离开第一和第二离子选择室的离子出口的离子例如产生用于注入的离子的质谱。

公开(公告)号：US06995365B2

公开(公告)日：2006-02-07

申请号：US10706324

申请日：2003-11-12

Applicant: Vincent R. Farnsworth

Inventor： Vincent R. Farnsworth

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/421

Abstract: An improved mass spectrometer is set forth. The mass spectrometer comprises an ion injector that is configured to provide a plurality of ions for analysis and an ion selection unit that is adapted to receive the plurality of ions from the ion injector and provide only those ions having a selected mass-to-charge ratio for detection/analysis. The ion selection unit includes an outer electrode and a plurality of inner electrodes. The plurality of ions provided by the ion injector are accepted into the interstitial region between the outer electrode and the plurality of inner electrodes. A power supply system is connected to the electrodes of the ion selection chamber. The power supply system is adapted to provide an oscillating voltage to at least one of the plurality of inner electrodes to facilitate separation of ions of the selected mass-to-charge ratio from ions of non-selected mass-to-charge ratios.

Abstract translation: 阐述了改进的质谱仪。 质谱仪包括被配置为提供用于分析的多个离子的离子注入器和适于从离子注入器接收多个离子的离子选择单元，并且仅提供具有选定的质荷比的那些离子 用于检测/分析。 离子选择单元包括外电极和多个内电极。 由离子注入器提供的多个离子被接纳到外部电极和多个内部电极之间的间隙区域中。 电源系统连接到离子选择室的电极。 电源系统适于向多个内部电极中的至少一个提供振荡电压，以便于将所选质量 - 电荷比的离子与未选择的质荷比的离子分离。

公开(公告)号：US06794647B2

公开(公告)日：2004-09-21

申请号：US10374771

申请日：2003-02-25

Applicant: Vincent R. Farnsworth ,  John R. Fassett

Inventor： Vincent R. Farnsworth ,  John R. Fassett

IPC: B01D5944

CPC classification number: H01J49/421

Abstract: An improved mass analyzer is set forth. In accordance with one embodiment, the mass analyzer employs a unique mass filter design that comprises an ion selection chamber in which ions are selected for detection based on their mass-to-charge ratio (m/Q) by subjecting them to a non-rotating, oscillating electric field that, ignoring any fringing effects, oscillates principally in a single coordinate plane (i.e., the y-z plane). The ions may be injected into the ion selection chamber at a significant angle with respect to the inlet of the chamber and in the single coordinate plane to raise the m/Q resolution to the desired level. In accordance with a further embodiment of the mass analyzer, an ion detection surface is arranged at the outlet of the ion selection chamber so that ions falling within a predetermined exit angle range are detected to the general exclusion of ions having other exit angles.

Abstract translation: 提出了一种改进的质量分析仪。 根据一个实施例，质量分析器采用独特的质量过滤器设计，其包括离子选择室，其中通过使离子选择室不旋转地基于它们的质荷比（m / Q）来选择用于检测的离子 忽略任何边缘效应的振荡电场主要在单个坐标平面（即yz平面）中振荡。 离子可以相对于室的入口以相对于入口的角度以及在单个坐标平面中被注入到离子选择室中，以将m / Q分辨率提高到期望的水平。 根据质量分析器的另一实施例，在离子选择室的出口设置离子检测表面，以便检测落入预定出射角范围内的离子以排除具有其它出射角的离子。