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公开(公告)号:US20240336614A1
公开(公告)日:2024-10-10
申请号:US18487690
申请日:2023-10-16
发明人: Upul Keerthi BANDARAGE , Cavan McKeon BLIGH , Diane BOUCHER , Michael John BOYD , Michael Aaron BRODNEY , Michael Philip CLARK , Veronique DAMAGNEZ , Lev Tyler Dewey FANNING , Robert Francis FIMOGNARI , Gabrielle Simone FLEMING , Kevin James GAGNON , Pedro Manuel GARCIA BARRANTES , Robert Daniel GIACOMETTI , Simon GIROUX , Ronald Lee GREY, JR. , Samantha GUIDO , Amy Beth HALL , Sarah Carol HOOD , Dennis James HURLEY , Mac Arthur JOHNSON, JR. , Peter Jones , Sarathy KESAVAN , Mei-Hsiu LAI , Siying LIU , Adam LOOKER , Brad MAXWELL , John Patrick MAXWELL , Ales MEDEK , Philippe Marcel NUHANT , Kirk Alan OVERHOFF , Setu RODAY , Stefanie ROEPER , Steven M. RONKIN , Rupa SAWANT , Yi SHI , Muna SHRESTHA , Marisa SPOSATO , Kathy STAVROPOULOS , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Qing TANG , Stephen THOMSON , Jinwang XU , Mariam ZAKY , Kevin Michael COTTRELL
IPC分类号: C07D487/04 , A61K9/16 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26
CPC分类号: C07D487/04 , A61K9/1635 , A61K9/1652 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26 , C07B2200/13
摘要: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):
tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.-
公开(公告)号:US20230339915A1
公开(公告)日:2023-10-26
申请号:US17916388
申请日:2021-04-02
发明人: Simon GIROUX , Michael Philip CLARK , Qing TANG , Philippe Marcel NUHANT , Peter JONES , David MESSERSMITH , Upul Keerthi BANDARAGE , Kevin Michael COTTRELL , Michael Aaron BRODNEY , Gabrielle Simone FLEMING , Jian WANG , Jinwang XU , Kevin Brett DANIEL , Michael John BOYD , Mark A. MORRIS , Nathan D. WAAL , Philip Noel COLLIER , Sarathy KESAVAN , Steven M. RONKIN , Hongbo DENG , Diane Marie BOUCHER , Lev T.D. FANNING , Amy B. HALL , Dennis James HURLEY , Mac Arthur JOHNSON, Jr. , John Patrick MAXWELL , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Stephen A. THOMSON , Veronique DAMAGNEZ
IPC分类号: C07D405/04 , C07D209/24 , C07D409/04 , C07D209/22 , C07D405/14 , C07D401/04 , C07D403/04 , C07D413/06 , C07D413/14
CPC分类号: C07D405/04 , C07D209/24 , C07D409/04 , C07D209/22 , C07D405/14 , C07D401/04 , C07D403/04 , C07D413/06 , C07D413/14
摘要: Novel compounds, compositions, and methods of using and preparing the same, which maybe useful for treating alpha-1 antitrypsin deficiency (AATD).
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公开(公告)号:US20230159580A1
公开(公告)日:2023-05-25
申请号:US17916481
申请日:2021-04-02
发明人: Simon GIROUX , Michael John BOYD , Robert Francis FIMOGNARI, Jr. , Mariam ZAKY , Ronald Lee GREY, Jr. , Jinwang XU , Sarathy KESAVAN , Philippe Marcel NUHANT , Pedro Manuel GARCIA BARRANTES , Peter JONES , Michael Aaron BRODNEY , Diane Marie BOUCHER , Lev T.D. FANNING , Amy B. HALL , Dennis James HURLEY , Mac Arthur JOHNSON, Jr. , John Patrick MAXWELL , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Stephen A. THOMSON , Veronique DAMAGNEZ , Kevin Michael COTTRELL
IPC分类号: C07H17/02 , C07D487/04 , C07D471/14
CPC分类号: C07H17/02 , C07D487/04 , C07D471/14 , C07B2200/05
摘要: Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.03,7]dodeca-1,3(7),5,8,11-pentaene derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD)
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公开(公告)号:US20230159502A1
公开(公告)日:2023-05-25
申请号:US17916484
申请日:2021-04-02
发明人: Simon GIROUX , Michael Philip CLARK , Michael Aaron BRODNEY , Philippe Marcel NUHANT , Emily Elizabeth ALLEN , Robert Francis FIMOGNARI, Jr. , Mariam ZAKY , Michael John BOYD , David D. DEININGER , Hu ZHANG , Hongbo DENG , Philip Noel COLLIER , Brad MAXWELL , Nathan D. WAAL , Steven M. RONKIN , Jian WANG , Qing TANG , Gabrielle Simone FLEMING , Peter JONES , Diane Marie BOUCHER , Lev T.D. FANNING , Amy B. HALL , Dennis James HURLEY , Mac Arthur JOHNSON, Jr. , John Patrick MAXWELL , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Stephen A. THOMSON , Veronique DAMAGNEZ , Kevin Michael COTTRELL , Upul Keerthi BANDARAGE
IPC分类号: C07D405/04 , C07D209/18 , C07D409/14 , C07D405/14 , C07D209/30 , C07D401/04 , C07D403/06 , C07D413/06 , C07F9/117 , C07H13/08 , C07D409/04 , C07D403/04 , C07F9/53 , C07D405/06 , C07D493/08 , C07D403/12 , C07D417/04 , C07D471/04 , C07D413/04 , C07D413/12 , C07D417/06
CPC分类号: C07D405/04 , C07D209/18 , C07D409/14 , C07D405/14 , C07D209/30 , C07D401/04 , C07D403/06 , C07D413/06 , C07F9/117 , C07H13/08 , C07D409/04 , C07D403/04 , C07F9/5325 , C07D405/06 , C07D493/08 , C07D403/12 , C07D417/04 , C07D471/04 , C07D413/04 , C07D413/12 , C07D417/06 , C07B2200/05
摘要: Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).
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公开(公告)号:US20230265080A1
公开(公告)日:2023-08-24
申请号:US18107786
申请日:2023-02-09
发明人: Upul Keerthi BANDARAGE , Cavan McKeon BLIGH , Michael John BOYD , Diane M. BOUCHER , Michael Aaron BRODNEY , Veronique DAMAGNEZ , Lev Tyler DEWEY FANNING , Mary Elizabeth ECCLES , Robert Francis FIMOGNARI, JR. , Kevin James GAGNON , Pedro M. GARCIA BARRANTES , Simon GIROUX , Ronald Lee GREY, JR. , Amy Beth HALL , Sarah Carol HOOD , Dennis James HURLEY , Joshua Kennedy HUSSEY , Mac Arthur JOHNSON, JR. , Peter JONES , Sarathy KESAVAN , Adam LOOKER , Brad D. MAXWELL , John Patrick MAXWELL , Ales MEDEK , Mettachit NAVAMAL , Philippe Marcel NUHANT , Setu RODAY , Stefanie ROEPER , Rupa SAWANT , Yi SHI , Rebecca Jane SWETT , Qing TANG , Timothy Lewis TAPLEY , Stephen A. THOMSON , Michael WALDO , Jinwang XU , Kevin Michael COTTRELL
IPC分类号: C07D403/04 , C07D519/00
CPC分类号: C07D403/04 , C07D519/00 , C07B2200/05 , C07B2200/13
摘要: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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公开(公告)号:US20210179587A1
公开(公告)日:2021-06-17
申请号:US16593118
申请日:2019-10-04
发明人: Upul Keerthi BANDARAGE , Cavan McKeon BLIGH , Michael John BOYD , Diane M. BOUCHER , Michael Aaron BRODNEY , Veronique DAMAGNEZ , Lev Tyler DEWEY FANNING , Mary Elizabeth ECCLES , Robert Francis FIMOGNARI, JR. , Kevin James GAGNON , Pedro M. GARCIA BARRANTES , Simon GIROUX , Ronald Lee GREY, JR. , Amy Beth HALL , Sarah Carol HOOD , Dennis James HURLEY , Joshua Kennedy HUSSEY , Mac Arthur JOHNSON, JR. , Peter JONES , Sarathy KESAVAN , Adam LOOKER , Brad D. MAXWELL , John Patrick MAXWELL , Ales MEDEK , Mettachit NAVAMAL , Philippe Marcel NUHANT , Setu RODAY , Stefanie ROEPER , Rupa SAWANT , Yi SHI , Rebecca Jane SWETT , Qing TANG , Timothy Lewis TAPLEY , Stephen A. THOMSON , Michael WALDO , Jinwang XU
IPC分类号: C07D403/04 , C07D519/00
摘要: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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